Effect of prostaglandin on urethral resistance and micturition

1983 ◽  
Vol 11 (1) ◽  
pp. 19-22 ◽  
Author(s):  
A. Kondo ◽  
M. Kobayashi ◽  
T. Takita ◽  
H. Narita
Keyword(s):  
Urethral Resistance

Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats

2009 ◽  
Vol 87 (11) ◽  
pp. 893-899 ◽  
Author(s):  
Gen Yamamoto ◽  
Fumio Soeda ◽  
Tetsuya Shirasaki ◽  
Kazuo Takahama
Keyword(s):  
Urinary Bladder ◽  
Cerebral Infarction ◽  
Flow Rate ◽  
Bladder Capacity ◽  
Left Middle Cerebral Artery ◽  
Sprague Dawley ◽  
Urinary Bladder Dysfunction ◽  
Sprague Dawley Rats ◽  
Urethral Resistance ◽  
Effective Doses

We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague–Dawley rats. Cerebral infarction was then induced by occlusion of the left middle cerebral artery. Twenty-four hours after cerebral infarction, the effect of each drug on micturition disorder was estimated for 5 parameters: bladder capacity, maximum voiding pressure, micturition latency, flow rate, and urethral resistance. Cerebral infarction markedly reduced bladder capacity, micturition latency, and flow rate and increased urethral resistance. After cerebral infarction, intravenous dosing of saline had no effect on these parameters. Dextromethorphan (20 mg/kg) and cloperastine (2.5 and 5.0 mg/kg) at antitussive effective doses significantly increased bladder capacity and micturition latency. Unlike dextromethorphan, cloperastine ameliorated decreases in flow rate and increases in urethral resistance caused by cerebral infarction. These results suggest that cloperastine may have therapeutic value for the treatment of disorders of the micturition reflex associated with cerebral infarction, and that the drug may become a base compound from which to develop more active drugs for such disorders.

Measurement of Urethral Resistance

1966 ◽  
Vol 96 (5) ◽  
pp. 746-755 ◽  
Author(s):  
Jacques G. Susset ◽  
Hyman H. Rabinovitch ◽  
Florentino Rosario ◽  
Kenneth J. Mackinnon
Keyword(s):  
Urethral Resistance

Division of Prostatic Anterior Fibromuscular Stroma Reduces Urethral Resistance in an Ex Vivo Human Prostate Model

Urology ◽  
2010 ◽  
Vol 76 (2) ◽  
pp. 511.e10-511.e13 ◽  
Author(s):  
Yaron Ehrlich ◽  
Richard S. Foster ◽  
Richard Bihrle ◽  
Liang Cheng ◽  
Yan Tong ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Human Prostate ◽  
Urethral Resistance

Biofeedback Therapy for Female Incontinence due to Low Urethral Resistance

1990 ◽  
Vol 143 (6) ◽  
pp. 1205-1208 ◽  
Author(s):  
Jacques G. Susset ◽  
Giuseppe Galea ◽  
Linda Read
Keyword(s):  
Biofeedback Therapy ◽  
Female Incontinence ◽  
Urethral Resistance
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