Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly

1987 ◽  
Vol 77 (2) ◽  
pp. 193-196 ◽  
Author(s):  
K. Madan ◽  
D. Lindhout ◽  
A. Palan
Keyword(s):  
Premature Centromere Division

scholarly journals Premature Centromere Division: A cytogenetic study.

CYTOLOGIA ◽  
1995 ◽  
Vol 60 (2) ◽  
pp. 159-165
Author(s):  
M. I. Arrieta ◽  
B. Martínez ◽  
M. Nuñez ◽  
A. Gil ◽  
A. Echarri ◽  
...  
Keyword(s):  
Cytogenetic Study ◽  
Premature Centromere Division

scholarly journals The effect of paclitaxel alone and in combination with cycloheximide on the frequency of premature centromere division in vitro

2010 ◽  
Vol 62 (1) ◽  
pp. 63-74
Author(s):  
V. Bajic ◽  
Z. Stanimirovic ◽  
Jevrosima Stevanovic ◽  
Zorka Milicevic ◽  
Lada Zivkovic ◽  
...  
Keyword(s):  
Fluorescent In Situ Hybridization ◽  
Human Peripheral Blood ◽  
Chromosome Instability ◽  
Micronucleus Assay ◽  
Peripheral Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Premature Centromere Division ◽  
Combinational Therapies

Premature centromere division (PCD) can be viewed as a manifestation of chromosome instability. In order to evaluate the ability of Paclitaxel (Ptx) and Cycloheximide (Cy) to induce PCD we used a cytokinesis block micronucleus assay (CBMN), fluorescent in situ hybridization (FISH), and the chromosome aberration (CA) assay in human peripheral blood lymphocytes. Results showed that Ptx can induce PCD alone or in combination with Cy. These findings call us to pay more attention to PCD as a parameter of genotoxicity in the pre-clinical research of mono and/or combinational therapies for cancer treatment.

scholarly journals Chromosome instability in Alzheimer’s disease

2011 ◽  
Vol 63 (3) ◽  
pp. 603-608 ◽  
Author(s):  
B. Spremo-Potparevic ◽  
L. Zivkovic ◽  
B. Plecas-Solarovic ◽  
V.P. Bajic
Keyword(s):  
Alzheimer’S Disease ◽  
Early Detection ◽  
Chromosome Instability ◽  
Genetic Research ◽  
Diagnostic Methods ◽  
Telomere Shortening ◽  
Premature Centromere Division ◽  
The World ◽  
Different Types ◽  
Potential Parameters

Alzheimer?s disease (AD), as the most common form of dementia, has for many years attracted the attention of researchers around the world, primarily because of the problems of reliable diagnostic methods that could help in the early detection of this devastating disease. One of the important aspects of genetic research related to AD is the analysis of chromosome instability which includes: aneuploidies of different chromosomes, telomere shortening and the phenomenon of premature centromere division (PCD). The aim of this study was to describe specific biomarkers in different types of cells as potential parameters for the diagnosis of AD in order to promptly recognize pre-symptomatic stages and prevent the development of disease and/or slow down its progression.

Association of nonsyndromic Wilms tumor with premature centromere division (PCD)

2002 ◽  
Vol 112 (2) ◽  
pp. 215-216 ◽  
Author(s):  
K. Méhes ◽  
P. Kajtár ◽  
G. Kosztolányi
Keyword(s):  
Wilms Tumor ◽  
Premature Centromere Division

scholarly journals Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome

Anemia ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Petra van der Lelij ◽  
Anneke B. Oostra ◽  
Martin A. Rooimans ◽  
Hans Joenje ◽  
Johan P. de Winter
Keyword(s):  
Fanconi Anemia ◽  
Bone Marrow Failure ◽  
Clinical Manifestations ◽  
Nijmegen Breakage Syndrome ◽  
Inherited Disease ◽  
Chromosomal Breakage ◽  
Metaphase Chromosomes ◽  
Roberts Syndrome ◽  
Premature Centromere Division ◽  
Multiple Symptoms

Fanconi anemia (FA) is a recessively inherited disease characterized by multiple symptoms including growth retardation, skeletal abnormalities, and bone marrow failure. The FA diagnosis is complicated due to the fact that the clinical manifestations are both diverse and variable. A chromosomal breakage test using a DNA cross-linking agent, in which cells from an FA patient typically exhibit an extraordinarily sensitive response, has been considered the gold standard for the ultimate diagnosis of FA. In the majority of FA patients the test results are unambiguous, although in some cases the presence of hematopoietic mosaicism may complicate interpretation of the data. However, some diagnostic overlap with other syndromes has previously been noted in cases with Nijmegen breakage syndrome. Here we present results showing that misdiagnosis may also occur with patients suffering from two of the three currently known cohesinopathies, that is, Roberts syndrome (RBS) and Warsaw breakage syndrome (WABS). This complication may be avoided by scoring metaphase chromosomes—in addition to chromosomal breakage—for spontaneously occurring premature centromere division, which is characteristic for RBS and WABS, but not for FA.

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