1,25-Dihydroxyvitamin D3 and 22-oxa-1,25-dihydroxyvitamin D3 in vivo nuclear receptor binding in developing bone during endochondral and intramembranous ossification

1994 ◽  
Vol 102 (3) ◽  
pp. 183-194 ◽  
Author(s):  
W. E. Stumpf ◽  
N. Koike ◽  
N. Hayakawa ◽  
K. Tokuda ◽  
K. Nishimiya ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Intramembranous Ossification ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Distribution of 1,25-dihydroxyvitamin D3[22-oxa] in vivo receptor binding in adult and developing skin

1995 ◽  
Vol 287 (3-4) ◽  
pp. 294-303 ◽  
Author(s):  
W. E. Stumpf ◽  
N. Koike ◽  
N. Hayakawa ◽  
K. Tokuda ◽  
K. Nishimiya ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
In Vivo Receptor Binding

Rat renal 25-hydroxyvitamin D3 1- and 24-hydroxylases: their in vivo regulation

1984 ◽  
Vol 246 (2) ◽  
pp. E168-E173 ◽  
Author(s):  
Y. Tanaka ◽  
H. F. DeLuca
Keyword(s):  
Vitamin D ◽  
Inorganic Phosphorus ◽  
Hydroxylase Activity ◽  
Deficient Diet ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Dietary Phosphorus ◽  
Low Calcium

The effects of thyroparathyroidectomy, parathyroid hormone, 1,25-dihydroxyvitamin D3, dietary calcium, dietary phosphorus, age, and sex on the renal 25-hydroxyvitamin D3 1- and 24-hydroxylases measured in vitro in rats have been studied. Thyroparathyroidectomy of vitamin D-deficient rats abolishes 25-hydroxyvitamin D3 1-hydroxylase activity, and administration of bovine parathyroid extract to the thyroparathyroidectomized rat restores diminished 1-hydroxylase activity. Both suppression and restoration of the enzyme activities require many hours (18-24 h) independent of rapid changes in serum calcium and inorganic phosphorus levels in response to these manipulations. Administration of 1,25-dihydroxyvitamin D3 to vitamin D-deficient rats suppresses 25-hydroxyvitamin D3 1-hydroxylase activity and stimulates 25-hydroxyvitamin D3 24-hydroxylase activity within 48 h. Rats maintained on a low-calcium or a low-phosphorus diet with a daily supplement of 20 IU vitamin D3 show high 25-hydroxyvitamin D3 1-hydroxylase activity and low 24-hydroxylase activity as compared with rats similarly treated but fed a diet containing adequate calcium or adequate phosphorus. When vitamin D-sufficient rats having suppressed renal 25-hydroxyvitamin D3 1-hydroxylase activity are placed on a low-calcium vitamin D-deficient diet for 7 days, the 1-hydroxylase activity is greatly stimulated in 6-wk-old rats but much less so in rats with advancing age.

scholarly journals 1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

1989 ◽  
Vol 86 (24) ◽  
pp. 9770-9773 ◽  
Author(s):  
M. Strom ◽  
M. E. Sandgren ◽  
T. A. Brown ◽  
H. F. DeLuca
Keyword(s):  
D3 Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Characterization of 1,25-dihydroxyvitamin D3 receptors and in vivo targeting of [3H]-1,25(OH)2D3 in the sheep placenta

Placenta ◽  
1989 ◽  
Vol 10 (6) ◽  
pp. 553-567 ◽  
Author(s):  
Richardus Ross ◽  
Jane Florer ◽  
Kevin Halbert ◽  
Lori McIntyre
Keyword(s):  
Dihydroxyvitamin D3 ◽  
D3 Receptors ◽  
1,25 Dihydroxyvitamin D3
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