Circadian influence on effect of propranolol on exercise-induced tachycardia in healthy subjects

1990 ◽  
Vol 38 (2) ◽  
Author(s):  
A. Fujimura ◽  
Y. Kumagai ◽  
K. Sugimoto ◽  
H. Nakashima ◽  
H. Kajiyama ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Exercise Induced

scholarly journals Exercise-Induced Release of Cardiac Troponins in Adolescent vs. Adult Swimmers

2021 ◽  
Vol 18 (3) ◽  
pp. 1285
Author(s):  
Rafel Cirer-Sastre ◽  
Francisco Corbi ◽  
Isaac López-Laval ◽  
Luis Enrique Carranza-García ◽  
Joaquín Reverter-Masià
Keyword(s):  
Cardiac Troponin ◽  
Healthy Subjects ◽  
Troponin T ◽  
Training Experience ◽  
Post Exercise ◽  
Baseline Values ◽  
Exercise Induced ◽  
Cardiac Troponins ◽  
Similar Peak ◽  
Apparently Healthy

To examine the exercise-induced release of cardiac troponin T (cTnT) in adolescent and adult swimmers. Thirty-two trained male (18 adolescents, 14 adults) swam at maximal pace in a 45 min distance trial, and blood samples were drawn before, immediately and 3 h after exercise for subsequent cTnT analysis and comparison. Having comparable training experience and baseline values of cTnT (p = 0.78 and p = 0.13), adults exercised at lower absolute and relative intensity (p < 0.001 and p < 0.001, respectively), but presented higher immediate cTnT after exercise than adolescents (p < 0.001). Despite that, peak concentrations were observed at 3 h post exercise and peak elevations were comparable between groups (p = 0.074). Fourteen (44%) apparently healthy subjects exceeded the cutoff value for myocardial infarction (MI). Adolescents presented a delayed elevation of cTnT compared with adults, but achieved similar peak values.

Acute effects of blood flow restriction on exercise-induced free radical production in young and healthy subjects

2018 ◽  
Vol 52 (4) ◽  
pp. 446-454 ◽  
Author(s):  
Christoph Centner ◽  
Denise Zdzieblik ◽  
Patrick Dressler ◽  
Bruno Fink ◽  
Albert Gollhofer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Free Radical ◽  
Healthy Subjects ◽  
Blood Flow Restriction ◽  
Acute Effects ◽  
Free Radical Production ◽  
Flow Restriction ◽  
Radical Production ◽  
Exercise Induced

scholarly journals Exercise induced changes in T1, T2 relaxation times and blood flow in the lower extremities in healthy subjects

2013 ◽  
Vol 15 (S1) ◽  
Author(s):  
Juliet Varghese ◽  
Debbie Scandling ◽  
Chikako Ono ◽  
Ashish Aneja ◽  
William A Kay ◽  
...  
Keyword(s):  
Blood Flow ◽  
Healthy Subjects ◽  
Relaxation Times ◽  
Lower Extremities ◽  
T2 Relaxation ◽  
Exercise Induced ◽  
Induced Changes

Modulation of Exercise-Induced Hypoalgesia Following an Exercise Intervention in Healthy Subjects

Pain Medicine ◽  
2020 ◽  
Vol 21 (12) ◽  
pp. 3556-3566
Author(s):  
Simon Hansen ◽  
Rasmus Christiansen Dalgaard ◽  
Pernille Schlosser Mikkelsen ◽  
Mathias Brandhøj Sørensen ◽  
Kristian Kjær Petersen
Keyword(s):  
Physical Performance ◽  
Healthy Subjects ◽  
Exercise Intervention ◽  
Military Training ◽  
Pressure Pain Threshold ◽  
Pain Mechanisms ◽  
Performance Capacity ◽  
Physical Performance Capacity ◽  
Exercise Induced ◽  
Chronic Pain Conditions

Abstract Background Exercise is recommended to promote and maintain health and as treatment for more than 25 diseases and pain conditions. Exercise-induced hypoalgesia (EIH), a measure of descending pain inhibitory control, has been found to be impaired in some chronic pain conditions, but it is currently unclear if EIH is modifiable. This study investigated whether a long-term exercise intervention could modulate EIH in healthy subjects. Methods In 38 healthy subjects, EIH was assessed as change in pressure pain threshold (PPT) after a three-minute isometric wall squat within the first week and after approximately seven weeks of military training (MT). Further, temporal summation of pain (TSP) and Knee injury and Osteoarthritis Outcome Score (KOOS) were assessed. Physical performance capacity was assessed using the Endurance 20-m shuttle run fitness test (20MSR). Hypoalgesic (EIH &gt; 0.0 kPa) and hyperalgesic (EIH ≤ 0.0 kPa) subgroups were defined based on baseline EIH. Change in EIH following MT was used as the primary outcome. Results Increased EIH (P = 0.008), PPT (P &lt; 0.003), and 20MSR (P &lt; 0.001) were found following MT, with no changes in TSP and KOOS (P &gt; 0.05). Subjects with a hyperalgesic EIH response at baseline (26% of the participants) presented significantly improved EIH following MT (P = 0.010). Finally, an association between 20MRS change and EIH change was found (r = 0.369, P = 0.023). Conclusions MT increased EIH, especially in subjects who demonstrated a hyperalgesic response at baseline. Improvement in physical performance capacity was associated with an improvement in EIH, indicating that improvement in physical performance capacity may improve central pain mechanisms.

scholarly journals SOD Derived from Bacillus amyloliquefaciens GF423 Has Protection Against Exercise-Induced Oxidative Stress in Healthy Subjects

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 764-764
Author(s):  
Yea-eun Nam ◽  
Yunsoo Kim ◽  
Yeni Lim ◽  
Hye Jin Kim ◽  
Oran Kwon
Keyword(s):  
Oxidative Stress ◽  
Healthy Subjects ◽  
Antioxidant Defense ◽  
Maximal Oxygen Consumption ◽  
Intervention Group ◽  
Lipid Peroxides ◽  
Experimental Period ◽  
Cellular Damage ◽  
Double Blind ◽  
Exercise Induced

Abstract Objectives Excessive reactive oxygen species (ROS) can cause cellular damage, causing a variety of degenerative diseases such as atherosclerosis, ischemic heart disease, and cancer. SOD is thought to play a central role in scavenging ROS generated in cells by enhancing the antioxidant defense system, including catalase and glutathione peroxidase. This study aims to test the hypothesis that exogenous SOD administration can help to protect against oxidative stress encountered at very early stages in the daily life of healthy subjects. Methods A total of 80 healthy adults were assigned to either an intervention group consuming B. amyloliquefaciens GF423 SOD (250 IU/capsule) daily for 8 weeks or a placebo in a randomized, double-blind and parallel design. Aerobic exercise by a treadmill for 30 minutes at an intensity of 60% of the maximal oxygen consumption (VO2max) of each subject was used to induce oxidative stress at the beginning and end of the experimental period. Blood and urine samples were collected immediately after and 30 min after the exercise challenge to measure biochemical markers related to oxidative stress and inflammation. Results A single administration of exogenous SOD induced a marked decrease in urinary lipid peroxides and plasma pro-inflammatory cytokines as compared to placebo administration. Furthermore, repeated administration of exogenous SOD for eight weeks resulted in a significant improvement of erythrocyte redox balance. Conclusions These findings suggest that the supply of exogenous SOD may be useful to enhance the antioxidant defense capacity and anti-inflammatory response in response to exercise-induced oxidative stress. Funding Sources This work was supported by the Bio-Synergy Research Project (NRF-2012M3A9C4048761) from the Ministry of Science, ICT, and Future Planning, and the BK21PLUS (Brain Korea 21 plus) program (22a20130012143) from the Ministry of Education and the GenoFocus Inc, Republic of Korea.

scholarly journals Reliability of a Fully Automated Interpretation ofγ-H2AX Foci in Lymphocytes of Moderately Trained Subjects under Resting Conditions

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Juliane Heydenreich ◽  
Christoph Otto ◽  
Frank Mayer ◽  
Anja Carlsohn
Keyword(s):  
Dna Damage ◽  
Healthy Subjects ◽  
Background Level ◽  
Limits Of Agreement ◽  
Trained Subjects ◽  
Coefficients Of Variation ◽  
Automated Interpretation ◽  
Baseline Levels ◽  
Exercise Induced ◽  
Healthy Males

Background. Analysis ofγ-H2AX foci is a promising approach to evaluate exercise-induced DNA damage. However, baseline levels and day-to-day variability ofγ-H2AX foci have not been investigated in healthy subjects at rest.Methods. Blood was taken from eight moderately trained healthy males (29 ± 3 yrs, 1.84 ± 0.03 m, and 85 ± 6 kg) at two separate days (M1/M2) after 24-hour exercise cessation. Number ofγ-H2AX foci per 100 lymphocytes (N), number of foci per affected lymphocyte (NAL), percentage of affected lymphocytes (PAL), and diameter (D) ofγ-H2AX foci were analyzed (mean ± SD). Differences between M1 and M2 were analyzed using pairedt-tests (α= 0.05). Day-to-day variability was evaluated by calculating the coefficients of variation (CV%), bias, and limits of agreement (LoA).Results. There were no statistically significant differences between M1 (N: 7.6 ± 4.4, NAL: 1.2 ± 0.2, PAL: 5.9 ± 2.6%, and D: 0.63 ± 0.07) and M2 (N: 8.4 ± 4.6, NAL: 1.3 ± 0.1, PAL: 6.9 ± 4.2%, and D: 0.66 ± 0.06). CV was calculated to be 98.5% (N), 88.9% (PAL), 11.3% (NAL), and 8.0% (D). Bias (LoA) was 0.75 (−15.2/13.7), −0.02 (−0.36/0.33), −1.0 (−11.9/9.9), and −0.04 (−0.16/0.09), respectively.Conclusions. Background level in healthy subjects is approximately 0.07 to 0.09γ-H2AX foci/cell. NAL and D are reliable measures.

Tertatolol Potentiates Exercise-Induced Atrial Natriuretic Peptide Release by Increasing Atrial Diameter in Healthy Subjects

Cardiology ◽  
1993 ◽  
Vol 83 (1) ◽  
pp. 16-24 ◽  
Author(s):  
I. Berlin ◽  
G. Deray ◽  
P. Lechat ◽  
G. Maistre ◽  
C. Landault ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Healthy Subjects ◽  
Peptide Release ◽  
Exercise Induced ◽  
Atrial Natriuretic

scholarly journals Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients

2002 ◽  
pp. 65-70 ◽  
Author(s):  
R Dall ◽  
J Kanaley ◽  
TK Hansen ◽  
N Moller ◽  
JS Christiansen ◽  
...  
Keyword(s):  
Body Composition ◽  
Aerobic Exercise ◽  
Healthy Subjects ◽  
Peak Level ◽  
Random Order ◽  
Cycle Ergometer ◽  
Control Group ◽  
Gh Replacement ◽  
Submaximal Aerobic Exercise ◽  
Exercise Induced

OBJECTIVE: To characterise plasma levels of the recently identified endogenous ligand for the GH secretagogue receptor (ghrelin) during submaximal aerobic exercise in healthy adults and in GH-deficient adults. DESIGN: Eight healthy males (mean+/-s.e. age, 40.8+/-2.9 years) and eight hypopituitary males with verified GH deficiency (mean+/-s.e. age, 40.8+/-4.7 years) underwent a baseline test of their peak aerobic capacity (VO(2) peak) and lactate threshold (LT) on a cycle ergometer, as well as an evaluation of body composition. The patients were then studied on two occasions in random order when they exercised for 45 min at their LT. On one occasion, GH replacement had been discontinued from the evening before, whereas on the other occasion they received their evening GH in addition to an intravenous infusion of GH (0.4 IU) during exercise the following day. The healthy subjects exercised at their LT on one occasion without GH. RESULTS: The patients were significantly more obese and had lower VO(2) max (corrected for body weight) and LT as compared with the control subjects. Exercise induced a peak in serum GH concentrations after 45 min in the control group (11.43+/-3.61 microg/l). Infusion of GH in the patients resulted in a peak level after 45 min, whereas no increase was detected when exercising without GH (9.77+/-2.40 (GH) vs 0.11+/-0.07 microg/l (no GH)). Plasma ghrelin levels did not change significantly with time in either study, and no correlations were detected between ghrelin levels and parameters such as GH and IGF-I levels, age or body composition. Plasma ghrelin levels were significantly lower during the study period with GH as compared with the study with no GH. CONCLUSIONS: Submaximal aerobic exercise of an intensity sufficient to stimulate GH release was not associated with significant alterations in plasma ghrelin concentrations, which indicated that systemic ghrelin is not involved in the exercise-induced stimulation of GH secretion. The observation that ghrelin levels were lower during GH replacement suggests that GH may feedback-inhibit systemic ghrelin release.

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