The effects of single doses of CL 284,846, lorazepam, and placebo on psychomotor and memory function in normal male volunteers

1993 ◽  
Vol 45 (4) ◽  
Author(s):  
D. Allen ◽  
H.V. Curran ◽  
M. Lader
Keyword(s):  
Memory Function ◽  
Normal Male ◽  
Male Volunteers ◽  
Cl 284,846

scholarly journals Brief Report: Urinary Excretion of 5-Methyl-Tetrahydrofolate in Man

Blood ◽  
1966 ◽  
Vol 27 (3) ◽  
pp. 386-388 ◽  
Author(s):  
ANNE McLEAN ◽  
I. CHANARIN
Keyword(s):  
Folic Acid ◽  
Urinary Excretion ◽  
Column Chromatography ◽  
Normal Male ◽  
Male Volunteers ◽  
Parenteral Dose ◽  
Pteroylglutamic Acid ◽  
Methyl Tetrahydrofolate

Abstract Tritium-labeled folic acid was given intravenously to normal male volunteers and the nature of the folate compounds appearing in the urine was studied by column chromatography and microbiologic assay. Three peaks of activity were obtained and these were due to (a) N10-formyl folate and p-amino-benzoylglutamate, (b) N 5-methyl-tetrahydrofolate, and (c) pteroylglutamic acid. Peaks (a) and (c) were tritium-labeled, but peak (b), containing 5-methyl-tetrahydrofolate, was not tritium-labeled. It was concluded that between one-quarter to one-third of the folic acid activity in urine following a small parenteral dose was due to 5-methyltetrahydrofolate, but that this arose by displacement from the tissue (presumably liver) and not from the administered dose of folic acid.

scholarly journals Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers

2001 ◽  
Vol 15 (1) ◽  
pp. 105-113 ◽  
Author(s):  
N. Bell ◽  
M. D. Karol ◽  
G. Sachs ◽  
P. Greski-Rose ◽  
D. E. Jennings ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Ph ◽  
Normal Male ◽  
Duration Of Effect ◽  
Male Volunteers

BROMOCRIPTINE-INDUCED MODULATION OF PLASMA ALDOSTERONE RESPONSE TO ACUTE STIMULATIONS

1979 ◽  
Vol 91 (2) ◽  
pp. 294-302 ◽  
Author(s):  
M. Birkhäuser ◽  
A. Riondel ◽  
M. B. Vallotton
Keyword(s):  
Angiotensin Ii ◽  
Dopaminergic System ◽  
Plasma Aldosterone ◽  
Normal Male ◽  
Upright Posture ◽  
Physiological Control ◽  
Male Volunteers ◽  
Basal Plasma ◽  
Dopaminergic Agent

ABSTRACT The influence of the dopaminergic agent 2-bromoergocryptine on plasma aldosterone response to acute stimulations was assessed in 14 normal male volunteers. Without modifying basal plasma aldosterone levels or urinary aldosterone excretion, bromocriptine retarded and diminished significantly the plasma aldosterone response to angiotensin II or ACTH, but did not alter the response to upright posture. These results point to a bromocriptineinduced modulation of the plasma aldosterone response to direct stimulations at the adrenal level. The present work brings further evidence for an effect of the dopaminergic system on the physiological control of aldosterone.

INFUSIONS OF hFSH AND hLH IN NORMAL MEN

1976 ◽  
Vol 81 (1) ◽  
pp. 234-242 ◽  
Author(s):  
J. M. Kjeld ◽  
S. F. Kuku ◽  
P. Harsoulis ◽  
T. R. Fraser ◽  
C. M. Puah ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Serum Testosterone ◽  
Significant Rise ◽  
Normal Male ◽  
Male Volunteers ◽  
Intravenous Infusions ◽  
Normal Men ◽  
Stimulating Hormone

ABSTRACT Standardized 4 h intravenous infusions of human follicle stimulating hormone (hFSH) and/or human luteinizing hormone (hLH) were given either separately or combined to 7 normal male volunteers. The infusions raised the serum gonadotrophin levels at least 10 (FSH) and 18 (LH) times above the basal ones. Serum testosterone (T) levels were measured serially before, during and after the infusions and, in 4 subjects, during a corresponding period of another normal day. During a normal or basal 24 h period fluctuations were seen and also a circadian rhythm with lower levels in the evening. The infusion of hFSH alone (3 subjects) did not alter the serum T levels. The infusion of hLH alone in 2 subjects raised serum T levels by 17% and 55% over those of the basal day. The combined FSH/LH infusion caused a significant rise (35–68%) in 4 subjects and greater rise in 2 of them than after infusion of the hLH alone. The serum T responses were gradual, reaching a maximum 7–8 h after the end of the infusion.

ENHANCED TSH STIMULATING EFFECT OF TRH BY SULPIRIDE IN MAN

1979 ◽  
Vol 91 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Alberto Zanoboni ◽  
Wanda Zanoboni-Muciaccia ◽  
Carlo Zanussi
Keyword(s):  
Normal Male ◽  
Blood Samples ◽  
Male Volunteers ◽  
Before And After ◽  
Pituitary Secretion ◽  
The Common ◽  
Pre Treatment ◽  
Tsh Levels

ABSTRACT Sulpiride, a specific dopaminergic blocker, was administered im to 6 normal male volunteers (100 mg) alone or in association with L-DOPA (500 mg per os, 90 min before sulpiride) or with TRH (400 μg iv in bolus, 30 min after sulpiride) and blood samples were obtained for TSH radioimmunoassay at various intervals before and after the treatments. Sulpiride alone produced a slight increase of plasma TSH levels which was inhibited by L-DOPA pre-treatment. The previous administration of sulpiride resulted in a marked increase of the TSH response to TRH. It is suggested that dopamine and TRH may interact to modulate pituitary secretion of both TSH and prolactin, though the hypophyseal thyrotrophs and lactotrophs show a different sensitivity to the common stimulatory and inhibitory substances.

A Database of [11C]WAY-100635 Binding to 5-HT1A Receptors in Normal Male Volunteers: Normative Data and Relationship to Methodological, Demographic, Physiological, and Behavioral Variables

NeuroImage ◽  
2002 ◽  
Vol 15 (3) ◽  
pp. 620-632 ◽  
Author(s):  
Eugenii A. Rabiner ◽  
Cristina Messa ◽  
Peter A. Sargent ◽  
Karen Husted-Kjaer ◽  
Andrew Montgomery ◽  
...  
Keyword(s):  
Normative Data ◽  
Normal Male ◽  
Male Volunteers ◽  
Way 100635 ◽  
Behavioral Variables

The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers

1999 ◽  
Vol 145 (3) ◽  
pp. 260-266 ◽  
Author(s):  
A. H. Young ◽  
B. J. Sahakian ◽  
T. W. Robbins ◽  
P. J. Cowen
Keyword(s):  
Cognitive Function ◽  
Chronic Administration ◽  
Normal Male ◽  
Male Volunteers
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