The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers

1999 ◽  
Vol 145 (3) ◽  
pp. 260-266 ◽  
Author(s):  
A. H. Young ◽  
B. J. Sahakian ◽  
T. W. Robbins ◽  
P. J. Cowen
Keyword(s):  
Cognitive Function ◽  
Chronic Administration ◽  
Normal Male ◽  
Male Volunteers

The effects of sub-chronic administration of hydrocortisone on hormonal and psychological responses to L-tryptophan in normal male volunteers

2002 ◽  
Vol 163 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Richard J. Porter ◽  
Peter Gallagher ◽  
Stuart Watson ◽  
Brian S. Lunn ◽  
Allan H. Young
Keyword(s):  
Chronic Administration ◽  
Normal Male ◽  
Psychological Responses ◽  
Male Volunteers

scholarly journals Brief Report: Urinary Excretion of 5-Methyl-Tetrahydrofolate in Man

Blood ◽  
1966 ◽  
Vol 27 (3) ◽  
pp. 386-388 ◽  
Author(s):  
ANNE McLEAN ◽  
I. CHANARIN
Keyword(s):  
Folic Acid ◽  
Urinary Excretion ◽  
Column Chromatography ◽  
Normal Male ◽  
Male Volunteers ◽  
Parenteral Dose ◽  
Pteroylglutamic Acid ◽  
Methyl Tetrahydrofolate

Abstract Tritium-labeled folic acid was given intravenously to normal male volunteers and the nature of the folate compounds appearing in the urine was studied by column chromatography and microbiologic assay. Three peaks of activity were obtained and these were due to (a) N10-formyl folate and p-amino-benzoylglutamate, (b) N 5-methyl-tetrahydrofolate, and (c) pteroylglutamic acid. Peaks (a) and (c) were tritium-labeled, but peak (b), containing 5-methyl-tetrahydrofolate, was not tritium-labeled. It was concluded that between one-quarter to one-third of the folic acid activity in urine following a small parenteral dose was due to 5-methyltetrahydrofolate, but that this arose by displacement from the tissue (presumably liver) and not from the administered dose of folic acid.

scholarly journals Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers

2001 ◽  
Vol 15 (1) ◽  
pp. 105-113 ◽  
Author(s):  
N. Bell ◽  
M. D. Karol ◽  
G. Sachs ◽  
P. Greski-Rose ◽  
D. E. Jennings ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Ph ◽  
Normal Male ◽  
Duration Of Effect ◽  
Male Volunteers

BROMOCRIPTINE-INDUCED MODULATION OF PLASMA ALDOSTERONE RESPONSE TO ACUTE STIMULATIONS

1979 ◽  
Vol 91 (2) ◽  
pp. 294-302 ◽  
Author(s):  
M. Birkhäuser ◽  
A. Riondel ◽  
M. B. Vallotton
Keyword(s):  
Angiotensin Ii ◽  
Dopaminergic System ◽  
Plasma Aldosterone ◽  
Normal Male ◽  
Upright Posture ◽  
Physiological Control ◽  
Male Volunteers ◽  
Basal Plasma ◽  
Dopaminergic Agent

ABSTRACT The influence of the dopaminergic agent 2-bromoergocryptine on plasma aldosterone response to acute stimulations was assessed in 14 normal male volunteers. Without modifying basal plasma aldosterone levels or urinary aldosterone excretion, bromocriptine retarded and diminished significantly the plasma aldosterone response to angiotensin II or ACTH, but did not alter the response to upright posture. These results point to a bromocriptineinduced modulation of the plasma aldosterone response to direct stimulations at the adrenal level. The present work brings further evidence for an effect of the dopaminergic system on the physiological control of aldosterone.

scholarly journals The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zahid Sadek Chowdhury ◽  
Mohammed Monzur Morshed ◽  
Mohammad Shahriar ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Sardar Mohd. Ashraful Islam ◽  
...  
Keyword(s):  
Psychomotor Performance ◽  
Visual Information ◽  
Visual Memory ◽  
Neuropsychological Test ◽  
Chronic Administration ◽  
Anterograde Amnesia ◽  
Healthy Human ◽  
Paired Associates ◽  
Male Volunteers ◽  
Significant Impairment

Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB) software to assess the chronic effect of alprazolam. We selected Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) tests for memory, Rapid Visual Information Processing (RVP) for attention, and Choice Reaction Time (CRT) for psychomotor performance twice: before starting the treatment and after the completion of the treatment. We found statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS in alprazolam group. The PAL mean trial to success and total correct matching in 0-second delay, 4-second delay, and all delay situation of DMS were impaired in alprazolam group. RVP total hits after two weeks of alprazolam treatment were improved in alprazolam group. But such differences were not observed in placebo group. In our study, we found that chronic administration of alprazolam affects memory but attentive and psychomotor performance remained unaffected.

INFUSIONS OF hFSH AND hLH IN NORMAL MEN

1976 ◽  
Vol 81 (1) ◽  
pp. 234-242 ◽  
Author(s):  
J. M. Kjeld ◽  
S. F. Kuku ◽  
P. Harsoulis ◽  
T. R. Fraser ◽  
C. M. Puah ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Serum Testosterone ◽  
Significant Rise ◽  
Normal Male ◽  
Male Volunteers ◽  
Intravenous Infusions ◽  
Normal Men ◽  
Stimulating Hormone

ABSTRACT Standardized 4 h intravenous infusions of human follicle stimulating hormone (hFSH) and/or human luteinizing hormone (hLH) were given either separately or combined to 7 normal male volunteers. The infusions raised the serum gonadotrophin levels at least 10 (FSH) and 18 (LH) times above the basal ones. Serum testosterone (T) levels were measured serially before, during and after the infusions and, in 4 subjects, during a corresponding period of another normal day. During a normal or basal 24 h period fluctuations were seen and also a circadian rhythm with lower levels in the evening. The infusion of hFSH alone (3 subjects) did not alter the serum T levels. The infusion of hLH alone in 2 subjects raised serum T levels by 17% and 55% over those of the basal day. The combined FSH/LH infusion caused a significant rise (35–68%) in 4 subjects and greater rise in 2 of them than after infusion of the hLH alone. The serum T responses were gradual, reaching a maximum 7–8 h after the end of the infusion.

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