Genetic and cytogenetic analysis of the ?Th-Ps? region of the Y chromosome of Drosophila hydei: evidence for dual functions of the lampbrush loop-forming fertility genes?

1991 ◽  
Vol 227 (2) ◽  
Author(s):  
JohannesH.P. Hackstein ◽  
KarlHeinz Gl�tzer ◽  
TheoJ.M. Hulsebos
Keyword(s):  
Y Chromosome ◽  
Cytogenetic Analysis ◽  
Drosophila Hydei ◽  
Fertility Genes ◽  
Dual Functions

A marked ring-Y-chromosome in Drosophila hydei with a new type of white variegation

Chromosoma ◽  
1979 ◽  
Vol 71 (1) ◽  
pp. 1-14 ◽  
Author(s):  
H. Beck ◽  
F. M. A. van Breugel ◽  
Ž. Srdić
Keyword(s):  
Y Chromosome ◽  
Drosophila Hydei ◽  
New Type

Somatically Acquired Isodicentric Y and Mosaic Loss of Chromosome Y in a Boy with Hypospadias

2018 ◽  
Vol 154 (3) ◽  
pp. 122-125 ◽  
Author(s):  
Mami Miyado ◽  
Koji Muroya ◽  
Momori Katsumi ◽  
Kazuki Saito ◽  
Masafumi Kon ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Cytogenetic Analysis ◽  
Chromosomal Rearrangements ◽  
Related Phenomenon ◽  
Limited Evidence ◽  
Elderly Men ◽  
Chromosome Y ◽  
Chromosomal Genes

Isodicentric Y chromosome [idic(Y)] represents a relatively common subtype of Y chromosomal rearrangements in the germline; however, limited evidence supports the postzygotic occurrence of idic(Y). Here, we report a boy with hypospadias and somatically acquired idic(Y). The 3.5-year-old boy has been identified in our previous study for patients with hypospadias. In the present study, cytogenetic analysis including FISH revealed a 45,X[5]/46,X,idic(Y)[7]/46,XY[8] karyotype. MLPA showed a mosaic deletion involving PPP1R12BP1 and RBMY2DP. The idic(Y) was likely to have been formed through aberrant recombination between P1 palindromes and subsequently underwent mosaic loss. The patient's phenotype was attributable to deletion of some Y chromosomal genes and/or mosaic loss of chromosome Y (mLOY). The results suggest that idic(Y) can originate in postzygotic cells via palindrome-mediated crossovers. Moreover, our data indicate that somatically acquired idic(Y) can trigger mLOY, which usually appears as an aging-related phenomenon in elderly men.

Localization of the lampbrush loop pair Nooses on the Y chromosome of Drosophila hydei by fluorescence in situ hybridization

Chromosoma ◽  
1993 ◽  
Vol 102 (8) ◽  
pp. 546-552 ◽  
Author(s):  
Ron Hochstenbach ◽  
Monique Wilbrink ◽  
Ron Suijkerbuijk ◽  
Wolfgang Hennig
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Y Chromosome ◽  
Drosophila Hydei

DNA clones and RNA transcripts of four lampbrush loops from the Y chromosome of Drosophila hydei

Cell ◽  
1983 ◽  
Vol 32 (1) ◽  
pp. 191-199 ◽  
Author(s):  
Eliezer Lifschytz ◽  
Dana Hareven ◽  
Aviva Azriel ◽  
Howard Brodsly
Keyword(s):  
Y Chromosome ◽  
Rna Transcripts ◽  
Drosophila Hydei ◽  
Lampbrush Loops

Y chromosome-specific mutations induced by a giant transposon in Drosophila hydei

1987 ◽  
Vol 207 (2-3) ◽  
pp. 455-465 ◽  
Author(s):  
Johannes H. P. Hackstein ◽  
Wolfgang Hennig ◽  
Ingrid Siegmund
Keyword(s):  
Y Chromosome ◽  
Drosophila Hydei

scholarly journals A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Matthew A. Lawlor ◽  
Weihuan Cao ◽  
Christopher E. Ellison
Keyword(s):  
Y Chromosome ◽  
Cell Types ◽  
Rna Seq ◽  
Distinct Population ◽  
Windows Of Opportunity ◽  
Copy Numbers ◽  
Distinct Cell ◽  
Pirna Pathway ◽  
Fertility Genes ◽  
Developmental Windows

AbstractTransposable elements (TEs) must replicate in germline cells to pass novel insertions to offspring. In Drosophila melanogaster ovaries, TEs can exploit specific developmental windows of opportunity to evade host silencing and increase their copy numbers. However, TE activity and host silencing in the distinct cell types of Drosophila testis are not well understood. Here, we reanalyze publicly available single-cell RNA-seq datasets to quantify TE expression in the distinct cell types of the Drosophila testis. We develop a method for identification of TE and host gene expression modules and find that a distinct population of early spermatocytes expresses a large number of TEs at much higher levels than other germline and somatic components of the testes. This burst of TE expression coincides with the activation of Y chromosome fertility factors and spermatocyte-specific transcriptional regulators, as well as downregulation of many components of the piRNA pathway. The TEs expressed by this cell population are specifically enriched on the Y chromosome and depleted on the X chromosome, relative to other active TEs. These data suggest that some TEs may achieve high insertional activity in males by exploiting a window of opportunity for mobilization created by the activation of spermatocyte-specific and Y chromosome-specific transcriptional programs.

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