scholarly journals Structurally modified fatty acids: Clinical potential as tracers of metabolism

1986 ◽  
Vol 12 (S1) ◽  
pp. S45-S48 ◽  
Author(s):  
R. Dudczak ◽  
R. Schmoliner ◽  
P. Angelberger ◽  
F. F. Knapp ◽  
M. M. Goodman
Keyword(s):  
Fatty Acids ◽  
Clinical Potential ◽  
Modified Fatty Acids

[29] Synthesis of modified fatty acids and glycerophospholipid analogs

1981 ◽  
pp. 408-433 ◽  
Author(s):  
Ramachandran Radhakrishnan ◽  
Robert J. Robson ◽  
Yohtaroh Takagaki ◽  
H. Gobind Khorana
Keyword(s):  
Fatty Acids ◽  
Modified Fatty Acids

scholarly journals A pathogen-responsive gene cluster for the production of highly modified fatty acids in tomato

2018 ◽  
Author(s):  
Ju Eun Jeon ◽  
Jung-Gun Kim ◽  
Curt R. Fischer ◽  
Cosima Dufour-Schroif ◽  
Kimberly Wemmer ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gene Cluster ◽  
Human Cancer ◽  
Lipid Production ◽  
Biosynthetic Gene Cluster ◽  
Response To Treatment ◽  
Direct Role ◽  
Human Cancer Cell Lines ◽  
Chemical Complexity ◽  
Modified Fatty Acids

AbstractIn response to biotic stress, plants reshape their complement of lipids to produce suites of highly modified fatty acids that bear unusual chemical functionality. Despite their chemical complexity, proposed roles in pathogen defense and presence in crop plants, little is known about the biosynthesis of these decorated fatty acids. Falcarindiol is a prototypical member of a suite of acetylenic lipids from carrot, tomato, and celery that inhibits growth of several fungal strains and human cancer cell lines. Here we report a set of clustered genes in tomato (Solanum lycopersicum) that are required for the production of falcarindiol in leaves in response to treatment with an adapted fungal pathogen, Cladosporium fulvum. Our approach is based on correlation of untargeted transcriptomic and metabolomic data sets in order to rapidly identify a candidate biosynthetic pathway. By reconstituting the initial biosynthetic steps in a heterologous host (Nicotiana benthamiana) and generating stable transgenic pathway mutants in tomato, we demonstrate a direct role for three genes in the cluster in falcarindiol biosynthesis. This work reveals a mechanism by which plants sculpt their lipid pool in response to pathogens, and provides critical insight into the biochemistry of alkynyl lipid production.One Sentence SummaryA biosynthetic gene cluster for the production of falcarindiol, a highly modified antifungal oxylipin found in edible plants.

Clinical Potential of Omega-3 Fatty Acids in the Treatment of Schizophrenia

CNS Drugs ◽  
2003 ◽  
Vol 17 (15) ◽  
pp. 1081-1091 ◽  
Author(s):  
Robin Emsley ◽  
Piet Oosthuizen ◽  
Susan J van Rensburg
Keyword(s):  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Clinical Potential

Formation of Modified Fatty Acids and Oxyphytosterols during Refining of Low Erucic Acid Rapeseed Oil

2003 ◽  
Vol 51 (15) ◽  
pp. 4284-4290 ◽  
Author(s):  
Pierre Lambelet ◽  
André Grandgirard ◽  
Stéphane Gregoire ◽  
Pierre Juaneda ◽  
Jean-Louis Sebedio ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Erucic Acid ◽  
Rapeseed Oil ◽  
Low Erucic Acid ◽  
Modified Fatty Acids

scholarly journals A Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato

Cell ◽  
2020 ◽  
Vol 180 (1) ◽  
pp. 176-187.e19 ◽  
Author(s):  
Ju Eun Jeon ◽  
Jung-Gun Kim ◽  
Curt R. Fischer ◽  
Niraj Mehta ◽  
Cosima Dufour-Schroif ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gene Cluster ◽  
Responsive Gene ◽  
Modified Fatty Acids

scholarly journals Calcium Mobilisation and CCK Secretion Induced by Modified Fatty Acids and Latex Microspheres Reveal Dual Receptor Mechanisms for Lipid Stimulation of STC‐1 Cells

2003 ◽  
Vol 553 (3) ◽  
pp. 759-773 ◽  
Author(s):  
S. Kazmi ◽  
S. S. Sidhu ◽  
T. J. Donohoe ◽  
M. Wickham ◽  
M. N. Jones ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Modified Fatty Acids ◽  
Stimulation Of

Modified fatty acids and their possible therapeutic targets in malignant diseases

2003 ◽  
Vol 7 (5) ◽  
pp. 663-677 ◽  
Author(s):  
Karl J Tronstad ◽  
Kjetil Berge ◽  
Rolf Kristian Berge ◽  
Øystein Bruserud
Keyword(s):  
Fatty Acids ◽  
Therapeutic Targets ◽  
Malignant Diseases ◽  
Modified Fatty Acids
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