Effects of regression of cardiac hypertrophy on myocardial contractility and ventricular myosin isoenzymes

1992 ◽  
Vol 118 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Takaaki Iwai ◽  
Nobuakira Takeda ◽  
Masahito Tuchiya ◽  
Tohru Arino ◽  
Akira Tanamura ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Myocardial Contractility ◽  
Myosin Isoenzymes ◽  
Ventricular Myosin ◽  
Regression Of Cardiac Hypertrophy

Effects of regression of cardiac hypertrophy on myocardial contractility and energetics

1990 ◽  
Vol 22 ◽  
pp. S102
Author(s):  
Takaaki Iwai ◽  
Nobuakira Takeda ◽  
Toru Arino ◽  
Akira Tanamura ◽  
Jie Yang ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Myocardial Contractility ◽  
Regression Of Cardiac Hypertrophy

Alteration of Atrial Natriuretic Peptide and Brain Natriuretic Peptide Gene Expression Associated with Progression and Regression of Cardiac Hypertrophy in Renovascular Hypertensive Rats

1996 ◽  
Vol 90 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Hideo Kawakami ◽  
Hideki Okayama ◽  
Mareomi Hamada ◽  
Kunio Hiwada
Keyword(s):  
Gene Expression ◽  
Atrial Natriuretic Peptide ◽  
Cardiac Hypertrophy ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mrna Levels ◽  
Hypertensive Rats ◽  
Regression Of Cardiac Hypertrophy ◽  
Peptide Gene ◽  
Atrial Natriuretic

1. We assessed the changes of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats (RHR). 2. Two-kidney, one-clip hypertensive rats (6-week-old male Wistar) were made and studied 6 (RHR-1) and 10 weeks (RHR-2) after the procedure. Regression of cardiac hypertrophy was induced by nephrectomy at 6 weeks after constriction, and the nephrectomized rats were maintained further for 4 weeks (nephrectomized rat: NEP). Sham operation was performed, and the rats were studied after 6 (Sham-1) and 10 weeks (Sham-2). Atrial natriuretic peptide and brain natriuretic peptide gene expression in the left ventricle was analysed by Northern blotting. 3. Plasma atrial natriuretic peptide and brain natriuretic peptide were significantly higher in RHR-1 and RHR-2 than in Sham-1, Sham-2 and NEP. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels in RHR-1 were approximately 7.2-fold and 1.8-fold higher than those in Sham-1, respectively, and the corresponding levels in RHR-2 were 13.0-fold and 2.4-fold higher than those in Sham-2, respectively. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels of NEP were normalized. Levels of atrial natriuretic peptide and brain natriuretic peptide mRNA were well correlated positively with left ventricular weight/body weight ratios. There was a significant positive correlation between the levels of atrial natriuretic peptide and brain natriuretic peptide mRNA (r = 0.86, P<0.01). 4. We conclude that the expression of atrial natriuretic peptide and brain natriuretic peptide genes is regulated in accordance with the degree of myocardial hypertrophy and that the augmented expression of these two natriuretic peptides may play an important role in the maintenance of cardiovascular haemodynamics in renovascular hypertension.

Electrophoretic Separation of Ventricular Myosin Isoenzymes Using a Native Polyacrylamide Minigel System

2003 ◽  
Vol 38 (1) ◽  
pp. 33-40 ◽  
Author(s):  
S. C. Garcia Pomblum ◽  
V. J. Pomblum ◽  
E. Gams ◽  
P. J. Reiser ◽  
J. D. Schipke
Keyword(s):  
Electrophoretic Separation ◽  
Myosin Isoenzymes ◽  
Ventricular Myosin

scholarly journals Calcineurin Inhibitor Attenuates the Development and Induces the Regression of Cardiac Hypertrophy in Rats With Salt-Sensitive Hypertension

Circulation ◽  
2000 ◽  
Vol 102 (16) ◽  
pp. 1996-2004 ◽  
Author(s):  
Masaki Shimoyama ◽  
Doubun Hayashi ◽  
Yunzeng Zou ◽  
Eiki Takimoto ◽  
Miho Mizukami ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Calcineurin Inhibitor ◽  
Regression Of Cardiac Hypertrophy ◽  
Salt Sensitive Hypertension
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