Short-term adaptation of the phase of the vestibulo-ocular reflex (VOR) in normal human subjects

1995 ◽  
Vol 106 (2) ◽  
Author(s):  
PhillipD. Kramer ◽  
Mark Shelhamer ◽  
DavidS. Zee
Keyword(s):  
Human Subjects ◽  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex ◽  
Normal Human

scholarly journals Asymmetric short-term adaptation of the vertical vestibulo-ocular reflex in humans

2006 ◽  
Vol 172 (3) ◽  
pp. 343-350 ◽  
Author(s):  
Sarah Marti ◽  
Christopher J. Bockisch ◽  
Dominik Straumann
Keyword(s):  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex

Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice

2017 ◽  
Vol 51 ◽  
pp. 122-131 ◽  
Author(s):  
Serajul I. Khan ◽  
Patrick P. Hübner ◽  
Alan M. Brichta ◽  
Doug W. Smith ◽  
Americo A. Migliaccio
Keyword(s):  
High Frequency ◽  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex

Context-specific short-term adaptation of the phase of the vestibulo-ocular reflex

1998 ◽  
Vol 120 (2) ◽  
pp. 184-192 ◽  
Author(s):  
P. D. Kramer ◽  
Mark Shelhamer ◽  
Grace C. Y. Peng ◽  
David S. Zee
Keyword(s):  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex ◽  
Context Specific

Dynamics of the human linear vestibulo-ocular reflex at medium frequency and modification by short-term training

2000 ◽  
Vol 10 (6) ◽  
pp. 271-282 ◽  
Author(s):  
Mark Shelhamer ◽  
Dale C. Roberts ◽  
David S. Zee
Keyword(s):  
Slow Component ◽  
Phase Changes ◽  
Slow Phase ◽  
Medium Frequency ◽  
Short Term ◽  
Ocular Reflex ◽  
Short Term Adaptation ◽  
Vestibulo Ocular Reflex ◽  
Catch Up ◽  
Saccadic Responses

We study here the effect of a short-term training paradigm on the gain and phase of the human translational VOR (the linear VOR: LVOR). Subjects were exposed to lateral sinusoidal translations on a sled, at 0.5 Hz, 0.3 g peak acceleration. With subjects tracking a remembered target at 1.2 m, the LVOR (slow-phase) under these conditions typically has a phase lead or lag, and a gain that falls short of compensatory. To induce short-term adaptation (training), we presented an earth-fixed visual scene at 1.2 m during sinusoidal translation ( × 1 viewing) for 20 minutes, so as to drive the LVOR toward compensatory phase and gain. We examined both the slow-phase and the saccadic responses to these stimuli. Testing after training showed changes in slow-component gain and phase which were mostly but not always in the compensatory direction. These changes were more consistent in naive subjects than in subjects who had previous LVOR experience. Changes in gain were seen with step as well as sinusoidal test stimuli; gain changes were not correlated with vergence changes. There was a strong correlation between gain changes and phase changes across subjects. Fast phases (catch-up saccades) formed a large component of the LVOR under our testing conditions (approximately 30% of the changes in gain but not in phase due to training.

Plasticity in the adult vestibulo-ocular reflex arc

1977 ◽  
Vol 278 (961) ◽  
pp. 319-334 ◽  
Keyword(s):  
Human Subjects ◽  
Neural Model ◽  
Reflex Response ◽  
Normal Vision ◽  
Ocular Reflex ◽  
Field Of Vision ◽  
Reflex Arc ◽  
Vestibulo Ocular Reflex ◽  
Plastic Changes

Human subjects with maintained reversal of their horizontal field of vision exhibit very substantial adaptive changes in their ‘horizontal’ vestibulo-ocular reflex (v.o.r.). Short durations (8 min) of vision reversal during natural head movement led to 20 % v.o.r. attenuation while long periods (4 weeks) eventually led to approximate reversal of the reflex. The reversed condition is approached by a complex, but highly systematic, series of changes in gain and phase of the reflex response relative to normal. Recovery after return to normal vision exhibits a similar duration, but different pattern, to that of the original adaptation. A chronic cat preparation with long-term optical reversal of vision has now been developed and shows similar adaptive and recovery changes at low test stimulus amplitudes, but different patterns of adaptive response at high amplitudes. An adaptive neural model employing mown vestibulo-ocular pathways is proposed to account for these experimentally observed plastic changes. The model is used to predict the adapted response to patterns of stimulation extending beyond the range of experimental investigation.

Short-term vestibulo-ocular reflex adaptation in humans

1994 ◽  
Vol 100 (2) ◽  
Author(s):  
Mark Shelhamer ◽  
Caroline Tiliket ◽  
Dale Roberts ◽  
PhillipD. Kramer ◽  
DavidS. Zee
Keyword(s):  
Short Term ◽  
Ocular Reflex ◽  
Vestibulo Ocular Reflex

scholarly journals Age-Related Changes in Human Vestibulo-Ocular Reflexes: Sinusoidal Rotation and Caloric Tests

1990 ◽  
Vol 1 (1) ◽  
pp. 49-59 ◽  
Author(s):  
R.J. Peterka ◽  
F.O. Black ◽  
M.B. Schoenhoff
Keyword(s):  
Human Subjects ◽  
Normal Population ◽  
Poor Correlation ◽  
Caloric Test ◽  
Compensatory Response ◽  
Ocular Reflex ◽  
Age Related ◽  
Test Parameters ◽  
Vestibulo Ocular Reflex ◽  
Effects Of Aging

The dynamic response properties of horizontal vestibulo-ocular reflex (VOR) were characterized in 216 human subjects ranging in age from 7 to 81 y. The effects of aging on VOR dynamics and parameter distributions that describe VOR responses to caloric and to sinusoidal rotational stimuli were determined in a putatively normal population. Caloric test parameters showed no consistent trend with age. Rotation test parameters showed declining response amplitude and slightly less compensatory response phase with increasing age. The magnitudes of these changes were not large relative to the variability within the population. The age-related trends in VOR were not consistent with the anatomic changes in the periphery reported by others that showed an increasing rate of peripheral hair cell and nerve fiber loss in subjects over 55 y. The poor correlation between physiological and anatomical data suggest that adaptive mechanisms in the central nervous system are important in maintaining the VOR.

Predictive Mechanisms of Head-Eye Coordination and Vestibulo-Ocular Reflex Suppression in Humans

1992 ◽  
Vol 2 (3) ◽  
pp. 193-212 ◽  
Author(s):  
G.R. Barnes ◽  
M.A. Grealy
Keyword(s):  
Peak Velocity ◽  
Human Subjects ◽  
Head Movements ◽  
Whole Body ◽  
Head Velocity ◽  
The Gaze ◽  
Ocular Reflex ◽  
Sinusoidal Motion ◽  
Smooth Component ◽  
Vestibulo Ocular Reflex

Head and eye movements of human subjects have been recorded during head-free pursuit in the horizontal plane of a target executing sinusoidal motion at a frequency of 0.26 to 0.78 Hz and a peak velocity of ±96∘/s. The target was not presented continuously but was exposed for brief durations of 120 to 320 ms as it passed through the centre of the visual field at peak velocity. This technique allowed the timing of each response to be assessed in relation to the onset of target appearance. During the first 3 to 4 target presentations, there was a progressive buildup of both head velocity and the smooth component of gaze velocity, while, simultaneously, the responses became more phase-advanced with respect to target onset. In the steady state, similar temporal response trajectories were observed for head and gaze velocity, which were initiated approximately 500 ms prior to target on-set, rose to a peak that increased with the duration of target exposure, and then decayed with a time constant of 0.5 to 1 s. Whenever the target failed to appear as expected, the gaze and head velocity trajectories continued to be made, indicating that predictive suppression of the vestibulo-ocular reflex (VOR) was taking place in darkness. In a further experiment, subjects attempted to suppress the VOR during whole body oscillation at 0.2 or 0.4 Hz on a turntable by fixating, a head-fixed target that appeared for 10 to 160 ms at the time of peak head velocity. Again, VOR suppression was initiated prior to target appearance in the same manner as for natural head movements, and when the target suddenly disappeared but rotation continued, predictive VOR suppression was observed in darkness. The similarity of these predictive effects to those obtained previously for head-fixed pursuit provides further support for the hypothesis that both pursuit and visual suppression of the VOR are controlled primarily by identical visual feedback mechanisms.

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