Morphological and functional changes in the tight junctions of the bile canaliculi induced by bile duct ligation

1978 ◽  
Vol 195 (2) ◽  
Author(s):  
Akitoshi Koga ◽  
Satoru Todo
Keyword(s):  
Bile Duct ◽  
Tight Junctions ◽  
Bile Duct Ligation ◽  
Bile Canaliculi ◽  
Functional Changes ◽  
Duct Ligation

Bile canaliculi morphology after bile duct ligation in the rat with portacaval shunt: a time course study

2008 ◽  
Vol 2 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Anne Vital ◽  
Paulette Bioulac-Sage ◽  
Christian Bedin ◽  
Charles Balabaud
Keyword(s):  
Bile Duct ◽  
Time Course ◽  
Bile Duct Ligation ◽  
Portacaval Shunt ◽  
Bile Canaliculi ◽  
Duct Ligation ◽  
Time Course Study

scholarly journals In vivo dynamic metabolic imaging of obstructive cholestasis in mice

2009 ◽  
Vol 296 (5) ◽  
pp. G1091-G1097 ◽  
Author(s):  
Feng-Chieh Li ◽  
Yuan Liu ◽  
Guan-Tarn Huang ◽  
Ling-Ling Chiou ◽  
Jhih-Huei Liang ◽  
...  
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Imaging System ◽  
Multiphoton Microscopy ◽  
Metabolic Imaging ◽  
Bile Canaliculi ◽  
Duct Ligation ◽  
Obstructive Cholestasis ◽  
Rhodamine B Isothiocyanate

We tried to image obstructive cholestasis by using a newly developed imaging system to measure the alterations of hepatobiliary function in living mice with their bile ducts ligated. A hepatic imaging window was installed on the upper abdomen soon after the mice underwent ligation of the common bile duct. On the next day, the mice received intravenous injection of rhodamine B isothiocyanate-dextran and carboxyfluorescein diacetate. The later would be transformed into fluorogenic carboxyfluorescein (detected at ∼500–550 nm) by hepatocytes and then excreted into bile canaliculi. The images were acquired by multiphoton microscopy. The fluorescence intensities at ∼500–550 nm within hepatocytes or sinusoids were measured in time series. In mice with bile duct ligation, bile canaliculi failed to appear during the whole observation period over 100 min following carboxyfluorescein diacetate injection, whereas the fluorescence was retained much longer within sinusoids. Furthermore, the fluorescence intensities in sinusoids were persistently higher than in hepatocytes during the course. Bile duct ligation impedes hepatocytes to excrete carboxyfluorescein into bile canaliculi. The kinetics of fluorescence intensities in hepatocytes and sinusoids indicated there is an active machinery operating backflow of this fluorogenic bile solute from hepatocytes into sinusoids in the liver with obstructive cholestasis.

Bid-mediated apoptosis does not contribute to cholestatic liver injury following bile duct ligation

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
P Nalapareddy ◽  
S Schüngel ◽  
MP Manns ◽  
H Jaeschke ◽  
A Vogel
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

HGF/c-Met and IL-6/gp130 cooperatively regulate liver homeostasis and antibacterial signalling after bile-duct-ligation

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
A Giebeler ◽  
S Erschfeld ◽  
C Birchmeier ◽  
C Trautwein ◽  
KL Streetz
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

2012 ◽  
Vol 32 (9) ◽  
pp. 1342-1353 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Sebastian Huss ◽  
Eddy Leur ◽  
Ute Haas ◽  
Ralf Weiskirchen
Keyword(s):  
Bile Duct ◽  
Gene Transfer ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Hepatocyte Apoptosis ◽  
Duct Ligation

Hepatic peroxiredoxin expression is increased in rats with chronic bile duct ligation

2000 ◽  
Vol 118 (4) ◽  
pp. A924
Author(s):  
Steven Douglas Colquhoun ◽  
Caroline A. Connelly ◽  
Lawrence Chen ◽  
Delai Zhao ◽  
Hungyi Shau
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Duct Ligation
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