Retrograde axoplasmic transport of neurosecretory material

1983 ◽  
Vol 233 (1) ◽  
Author(s):  
G. Alonso ◽  
I. Assenmacher
Keyword(s):  
Axoplasmic Transport ◽  
Neurosecretory Material

THE RELATION BETWEEN THE HYPOTHALAMIC NEUROSECRETION AND THE CORTICOTROPHIN RELEASE IN EXPERIMENTAL CONDITIONS

1960 ◽  
Vol XXXIV (I) ◽  
pp. 8-18 ◽  
Author(s):  
E. Kivalo ◽  
U. K. Rinne
Keyword(s):  
Paraventricular Nucleus ◽  
Median Eminence ◽  
Supraoptic Nucleus ◽  
Acute Stress ◽  
Neurosecretory Material ◽  
Experimental Conditions ◽  
Hypothalamic Cells ◽  
The One ◽  
Hypophysial Portal ◽  
Acth Release

ABSTRACT Acute stress, chronic stress plus hydration, cortisone treatment, cortisone treatment plus dehydration were used as methods of investigation and the relation between the neurosecretory activity of the hypothalamic supraoptic nucleus and paraventricular nucleus and the neurosecretory material around the hypophysial portal vessels of the median eminence on the one hand and the corticotrophin release on the other hand, has been studied in the rat. Whereas stress stimulates both the activity of the above mentioned cells of the hypothalamus and the ACTH release, stress plus hydration causes a depression of these hypothalamic cells but nevertheless causes a marked ACTH release. Cortisone inhibits the activity of the cells in the supraoptic nucleus and the paraventricular nucleus as well as the ACTH release whereas cortisone plus dehydration causes stimulation but inhibits the ACTH release. In some stress and cortisone treatment groups the variations of the neurosecretory material around the hypophysial portal vessels and of the ACTH release were found to show a correlation. It is concluded that the activity of the cells of the supraoptic nucleus and the paraventricular nucleus and the ACTH release do not seem to have any definite connection, whereas some observations indicate that the neurosecretory material in the region of the median eminence around the hypophysial portal vessels may have some significance in ACTH release.

The maintenance of axoplasmic transport by strontium and its localization in nerve fibers

1986 ◽  
Vol 17 (1) ◽  
pp. 55-61
Author(s):  
S. Ochs ◽  
R. A. Jersild ◽  
T. Breen ◽  
L. McKitrick
Keyword(s):  
Nerve Fibers ◽  
Axoplasmic Transport

Familial hypothalamic diabetes insipidus in rats (Brattleboro strain)

1964 ◽  
Vol 206 (2) ◽  
pp. 425-430 ◽  
Author(s):  
H. Valtin ◽  
H. A. Schroeder
Keyword(s):  
Diabetes Insipidus ◽  
Hypertonic Saline ◽  
Supraoptic Nucleus ◽  
Spontaneous Mutation ◽  
Urine Osmolality ◽  
Urine Flow ◽  
Neurosecretory Material ◽  
Carrier Protein ◽  
Marked Diminution ◽  
Long Evans

Familial hypothalamic diabetes insipidus ( DI) has arisen as an apparently spontaneous mutation from a strain of Long-Evans hooded rats being bred for unrelated researches not involving radioactivity. The DI rats decrease water intake and urine flow, and increase urine osmolality in response to injected vasopressin. They concentrate their urines only minimally or not at all in response to dehydration, hypertonic saline, nicotine, or stress, and their serum osmolalities and sodium concentrations are significantly higher than those of normal animals. They show marked diminution of neurosecretory material in the neurohypophysis and supraoptic nucleus. The data suggest that the deficiency causing DI in these rats is a lack or dearth of synthesis of vasopressin or its carrier protein, or both.

Batrachotoxin block of fast axoplasmic transport in mammalian nerve fibers

Science ◽  
1975 ◽  
Vol 187 (4181) ◽  
pp. 1087-1089 ◽  
Author(s):  
S Ochs ◽  
R Worth
Keyword(s):  
Nerve Fibers ◽  
Axoplasmic Transport ◽  
Mammalian Nerve
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