Relationship between altered axial curvature and neural tube closure in normal and mutant (curly tail) mouse embryos

1996 ◽  
Vol 193 (2) ◽  
Author(s):  
MarianC.E. Peeters ◽  
JohanW.M. Hekking ◽  
HennyW.M. Straaten ◽  
AlisaS.W. Shum ◽  
AndrewJ. Copp
Keyword(s):  
Neural Tube ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Curly Tail ◽  
Axial Curvature ◽  
Tube Closure

Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo

Development ◽  
1991 ◽  
Vol 113 (2) ◽  
pp. 671-678 ◽  
Author(s):  
F.A. Brook ◽  
A.S. Shum ◽  
H.W. Van Straaten ◽  
A.J. Copp
Keyword(s):  
Neural Tube ◽  
Mouse Embryo ◽  
Mouse Embryos ◽  
The Body ◽  
Neural Tube Closure ◽  
Posterior Neuropore ◽  
Curly Tail ◽  
Delayed Closure ◽  
Tube Closure

Delayed closure of the posterior neuropore (PNP) occurs to a variable extent in homozygous mutant curly tail (ct) mouse embryos, and results in the development of spinal neural tube defects (NTD) in 60% of embryos. Previous studies have suggested that curvature of the body axis may delay neural tube closure in the cranial region of the mouse embryo. In order to investigate the relationship between curvature and delayed PNP closure, we measured the extent of ventral curvature of the neuropore region in ct/ct embryos with normal or delayed PNP closure. The results show significantly greater curvature in ct/ct embryos with delayed PNP closure in vivo than in their normal littermates. Reopening of the posterior neuropore in non-mutant mouse embryos, to delay neuropore closure experimentally, did not increase ventral curvature, suggesting that increased curvature in ct/ct embryos is not likely to be a secondary effect of delayed PNP closure. Experimental prevention of ventral curvature in ct/ct embryos, brought about by implantation of an eyelash tip longitudinally into the hindgut lumen, ameliorated the delay in PNP closure. We propose, therefore, that increased ventral curvature of the neuropore region of ct/ct embryos imposes a mechanical stress, which opposes neurulation and thus delays closure of the PNP. Increased ventral curvature may arise as a result of a cell proliferation imbalance, which we demonstrated previously in affected ct/ct embryos.

Spatio-temporal curvature pattern of the caudal body axis for non-mutant and curly tail mouse embryos during the period of caudal neural tube closure

1997 ◽  
Vol 195 (3) ◽  
pp. 259-266 ◽  
Author(s):  
M. C. E. Peeters ◽  
Johan W. M. Hekking ◽  
Tryfon Vainas ◽  
J. Drukker ◽  
Henny W. M. van Straaten
Keyword(s):  
Neural Tube ◽  
Mouse Embryos ◽  
Body Axis ◽  
Neural Tube Closure ◽  
Curly Tail ◽  
Spatio Temporal ◽  
Tube Closure

scholarly journals Biomechanical coupling facilitates spinal neural tube closure in mouse embryos

2017 ◽  
pp. 201700934 ◽  
Author(s):  
Gabriel L. Galea ◽  
Young-June Cho ◽  
Gauden Galea ◽  
Matteo A. Molè ◽  
Ana Rolo ◽  
...  
Keyword(s):  
Neural Tube ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Tube Closure

scholarly journals Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos

2018 ◽  
Vol 149 ◽  
pp. 20-26 ◽  
Author(s):  
Amy Hughes ◽  
Nicholas D.E. Greene ◽  
Andrew J. Copp ◽  
Gabriel L. Galea
Keyword(s):  
Valproic Acid ◽  
Neural Tube ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Tube Closure

scholarly journals Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos

2008 ◽  
Vol 237 (4) ◽  
pp. 928-940 ◽  
Author(s):  
Wenchu Lin ◽  
Zhijing Zhang ◽  
Geraldine Srajer ◽  
Yi Chun Chen ◽  
Maosheng Huang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Histone Acetyltransferase ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Tube Closure

Differences in axial curvature correlate with species-specific rate of neural tube closure in embryos of chick, rabbit, mouse, rat and human

1998 ◽  
Vol 198 (3) ◽  
pp. 185-194 ◽  
Author(s):  
M. C. E. Peeters ◽  
Johan W. M. Hekking ◽  
Kohei Shiota ◽  
J. Drukker ◽  
Henny W. M. Van Straaten
Keyword(s):  
Neural Tube ◽  
Neural Tube Closure ◽  
Specific Rate ◽  
Axial Curvature ◽  
Species Specific ◽  
Tube Closure

scholarly journals Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos

FEBS Letters ◽  
2006 ◽  
Vol 580 (11) ◽  
pp. 2803-2807 ◽  
Author(s):  
Louisa P.E. Dunlevy ◽  
Katie A. Burren ◽  
Lyn S. Chitty ◽  
Andrew J. Copp ◽  
Nicholas D.E. Greene
Keyword(s):  
Neural Tube ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Tube Closure

scholarly journals Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure

2010 ◽  
Vol 30 (2) ◽  
pp. 284-291 ◽  
Author(s):  
Joshua F. Robinson ◽  
William C. Griffith ◽  
Xiaozhong Yu ◽  
Sungwoo Hong ◽  
Euvin Kim ◽  
...  
Keyword(s):  
Neural Tube ◽  
Mouse Embryos ◽  
Neural Tube Closure ◽  
Tube Closure
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