Early immunohistochemical detection of somatostatin-like and methionine-enkephablin-like neuropeptides in the brain of the migratory locust embryo

1984 ◽  
Vol 236 (2) ◽  
Author(s):  
Mich�le Romeuf ◽  
Christian R�my
Keyword(s):  
Immunohistochemical Detection ◽  
Migratory Locust ◽  
Locust Embryo ◽  
The Brain

NPY-like peptides occur in the nervous system and midgut of the migratory locust, Locusta migratoria and in the brain of the grey fleshfly, Sarcophaga bullata

Peptides ◽  
1988 ◽  
Vol 9 (5) ◽  
pp. 1027-1036 ◽  
Author(s):  
L. Schoofs ◽  
J.M. Danger ◽  
S. Jegou ◽  
G. Pelletier ◽  
R. Huybrechts ◽  
...  
Keyword(s):  
Nervous System ◽  
Locusta Migratoria ◽  
Migratory Locust ◽  
Sarcophaga Bullata ◽  
The Brain

Immunohistochemical detection of prolactin-releasing peptide2 in the brain of the inshore hagfish Eptatretus burgeri

2019 ◽  
Vol 274 ◽  
pp. 1-7 ◽  
Author(s):  
Masafumi Amano ◽  
Noriko Amiya ◽  
Naoyuki Yamamoto ◽  
Tomohiro Osugi ◽  
Kazuyoshi Tsutsui
Keyword(s):  
Immunohistochemical Detection ◽  
The Brain

Immunohistochemical Detection of Neural Stem Cells and Glioblastoma Stem Cells in the Subventricular Zone of Glioblastoma Patients

2021 ◽  
Vol 69 (5) ◽  
pp. 349-364 ◽  
Author(s):  
Vashendriya V.V. Hira ◽  
Remco J. Molenaar ◽  
Barbara Breznik ◽  
Tamara Lah ◽  
Eleonora Aronica ◽  
...  
Keyword(s):  
Stem Cells ◽  
Image Analysis ◽  
Neural Stem Cells ◽  
Surgical Resection ◽  
Subventricular Zone ◽  
Tumor Recurrence ◽  
Immunohistochemical Detection ◽  
Glioblastoma Stem Cells ◽  
Fluorescence Immunohistochemistry ◽  
The Brain

Glioblastoma usually recurs after therapy consisting of surgery, radiotherapy, and chemotherapy. Recurrence is at least partly caused by glioblastoma stem cells (GSCs) that are maintained in intratumoral hypoxic peri-arteriolar microenvironments, or niches, in a slowly dividing state that renders GSCs resistant to radiotherapy and chemotherapy. Because the subventricular zone (SVZ) is a major niche for neural stem cells (NSCs) in the brain, we investigated whether GSCs are present in the SVZ at distance from the glioblastoma tumor. We characterized the SVZ of brains of seven glioblastoma patients using fluorescence immunohistochemistry and image analysis. NSCs were identified by CD133 and SOX2 but not CD9 expression, whereas GSCs were positive for all three biomarkers. NSCs were present in all seven samples and GSCs in six out of seven samples. The SVZ in all samples were hypoxic and expressed the same relevant chemokines and their receptors as GSC niches in glioblastoma tumors: stromal-derived factor-1α (SDF-1α), C-X-C receptor type 4 (CXCR4), osteopontin, and CD44. In conclusion, in glioblastoma patients, GSCs are present at distance from the glioblastoma tumor in the SVZ. These findings suggest that GSCs in the SVZ niche are protected against radiotherapy and chemotherapy and protected against surgical resection due to their distant localization and thus may contribute to tumor recurrence after therapy.

Immunohistochemical detection of corticotropin-releasing hormone (CRH) in the brain and pituitary of the hagfish, Eptatretus burgeri

2016 ◽  
Vol 236 ◽  
pp. 174-180 ◽  
Author(s):  
Masafumi Amano ◽  
Noriko Amiya ◽  
Takehiko Yokoyama ◽  
Kengo Onikubo ◽  
Naoyuki Yamamoto ◽  
...  
Keyword(s):  
Immunohistochemical Detection ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
The Brain
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