Distribution of atrial natriuretic polypeptide (ANP)-containing cells in the rat heart and pulmonary vein Immunohistochemical study and radioimmunoassay

1988 ◽  
Vol 251 (3) ◽  
pp. 541-546 ◽  
Author(s):  
Hirotaka Toshimori ◽  
Masamitsu Nakazato ◽  
Kiyotaka Toshimori ◽  
Junko Asai ◽  
Shigeru Matsukura ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Rat Heart ◽  
Immunohistochemical Study ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

The distribution of atrial natriuretic polypeptide (ANP)-containing cells in the adult rat heart

1988 ◽  
Vol 177 (6) ◽  
pp. 477-484 ◽  
Author(s):  
Hirotaka Toshimori ◽  
Kiyotaka Toshimori ◽  
Chikayoshi Ōura ◽  
Hisayuki Matsuo ◽  
Shigeru Matsukura
Keyword(s):  
Rat Heart ◽  
Adult Rat ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

Secretory form of atrial natriuretic polypeptide as cardiac hormone in humans and rats

1987 ◽  
Vol 65 (8) ◽  
pp. 1756-1761 ◽  
Author(s):  
Kazuwa Nakao ◽  
Akira Sugawara ◽  
Shozo Shiono ◽  
Yoshihiko Saito ◽  
Narito Morii ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Performance Liquid Chromatography ◽  
Coronary Sinus ◽  
Rat Heart ◽  
High Performance ◽  
Low Molecular Weight ◽  
Reverse Phase ◽  
Atrial Natriuretic Polypeptide ◽  
Molecular Weight Form ◽  
Atrial Natriuretic

To elucidate the secretory form of atrial natriuretic polypeptide from the atrium, the molecular form of atrial natriuretic polypeptide in the perfusate from the isolated beating rat heart and in plasma taken at the coronary sinus of 10 patients during cardiac catheterization has been investigated using high performance gel permeation chromatography and reverse phase high performance liquid chromatography coupled with radioimmunoassay for atrial natriuretic polypeptide. Atrial natriuretic polypeptide in the perfusate from the rat heart showed a single peak eluting at the position of a low molecular weight form of atrial natriuretic polypeptide, without any detectable amounts of atrial natriuretic polypeptide with high molecular weights. The major component of atrial natriuretic polypeptide in the rat heart perfusate co-migrated with rat α-atrial natriuretic polypeptide in reverse phase high performance liquid chromatography. In 9 out of 10 patients atrial natriuretic polypeptide in plasma taken at the coronary sinus revealed a single peak of atrial natriuretic polypeptide emerging at the position of human α-atrial natriuretic polypeptide in gel filtration. Only one plasma sample had a small quantity of high molecular weight forms with the predominant low molecular weight form of atrial natriuretic polypeptide. The major component of atrial natriuretic polypeptide in the plasma extract from the coronary sinus was identified with human α-atrial natriuretic polypeptide. These results indicate that α-ANP, a 28-amino acid polypeptide, is secreted as a cardiac hormone into the coronary blood stream from the atrium.

Immunohistochemical study of atrial natriuretic polypeptides in the embryonic, fetal and neonatal rat heart

1987 ◽  
Vol 248 (3) ◽  
pp. 627-633 ◽  
Author(s):  
Hirotaka Toshimori ◽  
Kiyotaka Toshimori ◽  
Chikayoshi Ōura ◽  
Hisayuki Matsuo
Keyword(s):  
Rat Heart ◽  
Immunohistochemical Study ◽  
Neonatal Rat ◽  
Neonatal Rat Heart ◽  
Atrial Natriuretic

Presence of atrial natriuretic polypeptide in the pulmonary vein and vena cava

1987 ◽  
Vol 146 (3) ◽  
pp. 1465-1470 ◽  
Author(s):  
Junko Asai ◽  
Masamitsu Nakazato ◽  
Hirotaka Toshimori ◽  
Shigeru Matsukura ◽  
Kenji Kangawa ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Vena Cava ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

Hemodynamic effects of α-human atrial natriuretic polypeptide (α-HANP) in rats

1985 ◽  
Vol 109 (3) ◽  
pp. 405-407 ◽  
Author(s):  
Akira Sasaki ◽  
Osamu Kida ◽  
Kenji Kangawa ◽  
Hisayuki Matsuo ◽  
Kenjiro Tanaka
Keyword(s):  
Hemodynamic Effects ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

Peptides derived from atrial natriuretic polypeptide precursor in human and monkey brains

1988 ◽  
Vol 6 (4) ◽  
pp. S309-313 ◽  
Author(s):  
Hiroshi Itoh ◽  
Kazuwa Nakao ◽  
Masashi Mukoyama ◽  
Kiminori Hosada ◽  
Shozo Shiono ◽  
...  
Keyword(s):  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic
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