Simultaneous statistical analysis of intraocular pressure and resistance to aqueous outflow: Significance in early diagnosis of glaucoma

1969 ◽  
Vol 27 (1) ◽  
pp. 252-256 ◽  
Author(s):  
R. Weekers ◽  
G. Lennes ◽  
E. Prijot
Keyword(s):  
Intraocular Pressure ◽  
Statistical Analysis ◽  
Early Diagnosis ◽  
Aqueous Outflow

Dietary Omega 3 Fatty Acids Decrease Intraocular Pressure with Age by Increasing Aqueous Outflow

2007 ◽  
Vol 48 (2) ◽  
pp. 756 ◽  
Author(s):  
Christine T. O. Nguyen ◽  
Bang V. Bui ◽  
Andrew J. Sinclair ◽  
Algis J. Vingrys
Keyword(s):  
Fatty Acids ◽  
Intraocular Pressure ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Aqueous Outflow

scholarly journals Morphological changes in the trabecular meshwork and Schlemm’s canal after treatment with topical intraocular pressure-lowering agents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hye Park ◽  
Hyun Woo Chung ◽  
Eun Gyu Yoon ◽  
Min Jung Ji ◽  
Chungkwon Yoo ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Trabecular Meshwork ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Before And After ◽  
Treatment Naïve ◽  
Aqueous Outflow

AbstractGlaucoma treatment is usually initiated with topical medication that lowers the intraocular pressure (IOP) by reducing the aqueous production, enhancing the aqueous outflow, or both. However, the effect of topical IOP-lowering medications on the microstructures of the aqueous outflow pathway are relatively unknown. In this retrospective, observational study, 56 treatment-naïve patients with primary open-angle glaucoma were enrolled. Images of the nasal and temporal corneoscleral limbus were obtained using anterior segment optical coherence tomography (AS-OCT). The conjunctival vessels and iris anatomy were used as landmarks to select the same limbal area scan, and the trabecular meshwork (TM) width, TM thickness, and Schlemm’s canal (SC) area were measured before and after using the IOP-lowering agents for 3 months. Among the 56 patients enrolled, 33 patients used prostaglandin (PG) analogues, and 23 patients used dorzolamide/timolol fixed combination (DTFC). After 3 months of DTFC usage, the TM width, TM thickness, and SC area did not show significant changes in either the nasal or temporal sectors. Conversely, after prostaglandin analog usage, the TM thickness significantly increased, and the SC area significantly decreased (all P < 0.01). These findings warrant a deeper investigation into their relationship to aqueous outflow through the conventional and unconventional outflow pathways after treatment with PG analogues.

scholarly journals Anatomy of the Aqueous Outflow Drainage Pathways

2020 ◽  
pp. 11-19
Author(s):  
Kay Lam ◽  
Mitchell Lawlor
Keyword(s):  
Intraocular Pressure ◽  
Aqueous Humour ◽  
Treatment Strategies ◽  
Full Thickness ◽  
Suprachoroidal Space ◽  
Subconjunctival Space ◽  
New Treatment ◽  
The Right ◽  
Normal Angle ◽  
Aqueous Outflow

Abstract Lowering intraocular pressure (IOP) has been central to glaucoma care for over a century. Minimally invasive glaucoma surgical (MIGS) devices are able to exploit different aspects of aqueous outflow to reduce IOP. Increasing aqueous humour outflow may be achieved either through facilitating the existing pathways of Schlemm’s canal and the suprachoroidal space or to bypass the normal angle anatomy to create a full thickness fistula into the subconjunctival space. A complete understanding of angle anatomy and outflow pathways is important to develop new treatment strategies, improve current ones and better target the right operation for particular glaucoma subtypes.

Diabetic foot early diagnosis and statistical analysis by spectral terahertz reflection images

2018 ◽  
Author(s):  
Goretti G. Hernandez-Cardoso ◽  
Mariana Alfaro-Gomez ◽  
Sandra C. Rojas-Landeros ◽  
Irving Salas-Gutierrez ◽  
Enrique Castro-Camus
Keyword(s):  
Statistical Analysis ◽  
Early Diagnosis ◽  
Diabetic Foot

Intraocular pressure and aqueous outflow facility in light-induced avian buphthalmos

1970 ◽  
Vol 9 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Jean K. Lauber ◽  
James E. Boyd ◽  
T.A.S. Boyd
Keyword(s):  
Intraocular Pressure ◽  
Outflow Facility ◽  
Aqueous Outflow

scholarly journals Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
James J. Yahaya
Keyword(s):  
Spinal Cord ◽  
Statistical Analysis ◽  
Early Diagnosis ◽  
Statistical Difference ◽  
Statistical Significance ◽  
Tertiary Hospital ◽  
Categorical Variables ◽  
Ethical Approval ◽  
The Mean ◽  
Malignant Neoplasia

Abstract Background Early diagnosis of spinal cord neoplasia serves patients from developing a number of complications and even death. Methods After obtaining ethical approval, retrospectively, a total of 53 tissue blocks of patients attended at the spinal ward were reviewed. Statistical analysis was done using SPSS version 20.0, and p value of less than 0.05 was applied to establish the existence of statistical significance between the compared categorical variables. Results The mean age of the patients was 30.7 ± 15.96 years. Most of the patients 32.1% (n = 17) were aged ≤ 19 years, and majority of the neoplasia 77.3% (n = 41) were extramedullary. Also, majority of the neoplasia 60.4% (n = 32) were benign and the malignant ones were 35.8% (n = 19). The mean duration of onset of symptoms for benign and malignant neoplasia in this study was 13.1 ± 16.4 and 3.4 ± 2.8 years, respectively, with statistical difference (95% CI 2.09–17.35, p = 0.014). Conclusion The patients with spinal cord neoplasia in the present study were of young age, and majority of them had benign neoplasia that were extramedullary located. The mean duration of onset of symptoms for patients with malignant neoplasia was significantly shorter than that of benign neoplasia.

scholarly journals Study of Intraocular Pressure following Neodynium Yttrium Aluminium Garnet Laser Capsulotomy with the Use of Brimonidine: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (233) ◽  
Author(s):  
Laxmi Devi Manandhar ◽  
Nanda Gurung ◽  
Koshal Shrestha ◽  
Binita Bhattarai ◽  
Manita Godar ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Statistical Analysis ◽  
Cross Sectional Study ◽  
Posterior Capsular Opacification ◽  
Yttrium Aluminium Garnet ◽  
Sectional Study ◽  
Cross Sectional ◽  
Yttrium Aluminium ◽  
The Mean ◽  
Yttrium Aluminium Garnet Laser

Introduction: Posterior capsular opacification is a common complication after cataract surgery. Neodynium Yttrium Aluminium Garnet laser capsulotomy is still the preferred treatment for posterior capsular opacification. This study was done to determine the use of Brimonidine eye drop in preventing the rise of intraocular pressure post-Neodynium Yttrium Aluminium Garnet laser capsulotomy. Methods: A descriptive cross-sectional study was conducted in Lumbini eye institute and research center, Bhairahawa, Nepal, in 200 eyes with posterior capsular opacification using Brimonidine from Feb 1, 2019, to July 30, 2019. The Institutional Review Committee approved the study with approval number 0237. A convenient sampling method was used. Pre-capsulotomy best-corrected visual acuity, slit-lamp examination of the anterior segment, and dilated fundus examination were done. Intraocular pressure was measured with Goldmann Applanation Tonometer. Post capsulotomy patients were evaluated after one hour, two hours, and two weeks for intraocular pressure and any complications. The statistical analysis was done using Statistical Package of Social Sciences version 20.0 statistical analysis software. The descriptive statistical analysis of the study was done after the collection of the data. Results: Mean age of patients at presentation was 61.61±SD 1.09. The mean intraocular pressure following Neodynium Yttrium aluminum garnet laser capsulotomy using brimonidine at 1 hour was 12.73±3.3 mmHg.and two hours was 11.98±3.2 mmHg. The mean energy per pulse was 2.3±SD 0.3 mJ. The mean duration of posterior capsular opacification from cataract surgery was 22.28 weeks. Conclusions: Neodynium Yttrium Aluminium Garnet laser capsulotomy had lower intraocular pressure after the Brimonidine eye drop procedure. The maximum mean reduction in intraocular pressure was observed after two hours.

scholarly journals Early diagnosis and misdiagnosis of Glaucoma

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
Ghulam Sabir
Keyword(s):  
Intraocular Pressure ◽  
Early Diagnosis ◽  
Early Stage ◽  
Visual Fields ◽  
Fundus Examination ◽  
Group Iii ◽  
Group I ◽  
Initial Stage ◽  
Diagnosis Method ◽  
First Time

Aim: To recognize and draw a line between glaucomatous and non glaucomatous patients at very early stage. Objects: Such silent dangerous ocular problem must be recognized and treated at very initial stage to avoid subsequent complications. Diagnosis: History and all the parameters including intraocular pressure, vision, visual fields and fundus examination were evaluated for diagnosis. Method of study: The study was done at General Hospital and Services Hospital Lahore from 1987 to early 1991. All the patients over the age of 40 year whether coming for first time or already on antiglaucoma treatment were evaluated thoroughly. Patients were examined by senior colleagues also. Results: Total 180 patients were included in study, 120 males 60 females. They were divided into four groups. Group I and II were diagnosed early and included 120 patients with no complications. Group-III and IV were misdiagnosed and included 60 patients. Discussion Until and unless, special care is taken to focus on the diagnosis, it is usually missed with many complications. It is only the casual behaviour of treating physician who considers the patient`s complaint lightly and examines them superficially. Conclusion: Although misdiagnosed cases are relatively less than truly misdiagnosed cases of glaucoma yet they form an important fraction of patients who may go blind within coming years. It is therefore necessary to diagnose such patients at very early stage. The surgeon should take special interest to diagnose such patients. One should not hesitate to consult senior colleagues in doubtful cases. Proper counseling for non cooperative patients is very necessary.

scholarly journals Application of vectorcardiography and recurrence-based methods to analysis of ECG signals

2018 ◽  
Vol 241 ◽  
pp. 01015
Author(s):  
Joanna Iwaniec ◽  
Marek Iwaniec ◽  
Antoni Kalukiewicz
Keyword(s):  
Statistical Analysis ◽  
Phase Space ◽  
Early Diagnosis ◽  
Signal Analysis ◽  
Myocardial Injury ◽  
Age Groups ◽  
Continuous Series ◽  
Medical Database ◽  
Recurrence Plots ◽  
Ecg Signals

The paper concerns application of vectorcardiography and recurrence-based methods to analyze ECG signals. The first method involves recording the direction and magnitude of electrical forces of the heart by means of a continuous series of vectors that form a curving line around a center, while the second consists in representing the ECG signals in the phase space and searching for the recurrence properties of the registered signals. In both methods, change of analysis domain offers new opportunities for early diagnosis. In this work, discussed methods have been used for the purposes of analysis of selected ECG signals stored in the medical database. Vectorcardiograms were determined on the basis of ECG signals for the Farnk's leads. Signal analysis was carried out with the application of the recurrence plots (RP) method. The proposed approach simplifies assessment of the signal information content by providing patterns characteristic for different myocardial injury. Carried out research requires complementation by results of statistical analysis for various age groups and degrees of myocardial injury.

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