Immunocytochemical localization of somatostatin and vasotocin in the brain of the Pacific hagfish, Eptatretus stouti

1983 ◽  
Vol 229 (3) ◽  
Author(s):  
Masumi Nozaki ◽  
Aubrey Gorbman
Keyword(s):  
Immunocytochemical Localization ◽  
The Pacific ◽  
The Brain

scholarly journals Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

2016 ◽  
Vol 283 (1823) ◽  
pp. 20152397 ◽  
Author(s):  
Paul Alan Cox ◽  
David A. Davis ◽  
Deborah C. Mash ◽  
James S. Metcalf ◽  
Sandra Anne Banack
Keyword(s):  
Neurofibrillary Tangles ◽  
Dietary Exposure ◽  
Cyanobacterial Toxin ◽  
Amyloid Deposits ◽  
The Pacific ◽  
Dietary Amino Acid ◽  
Environmental Toxin ◽  
Β Amyloid ◽  
The Brain ◽  
Lateral Sclerosis

Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the Pacific island of Guam. Many Chamorros with the disease suffer dementia, and in some villages one-quarter of the adults perished from the disease. Like Alzheimer's, the causal factors of Guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) are poorly understood. In replicated experiments, we found that chronic dietary exposure to a cyanobacterial toxin present in the traditional Chamorro diet, β- N -methylamino- l -alanine (BMAA), triggers the formation of both NFT and β-amyloid deposits similar in structure and density to those found in brain tissues of Chamorros who died with ALS/PDC. Vervets ( Chlorocebus sabaeus ) fed for 140 days with BMAA-dosed fruit developed NFT and sparse β-amyloid deposits in the brain. Co-administration of the dietary amino acid l -serine with l -BMAA significantly reduced the density of NFT. These findings indicate that while chronic exposure to the environmental toxin BMAA can trigger neurodegeneration in vulnerable individuals, increasing the amount of l -serine in the diet can reduce the risk.

Immunocytochemical localization of aromatase in the brain

1990 ◽  
Vol 514 (2) ◽  
pp. 327-333 ◽  
Author(s):  
Jacques Balthazart ◽  
Agnes Foidart ◽  
Nobuhiro Harada
Keyword(s):  
Immunocytochemical Localization ◽  
The Brain
Sign in / Sign up

Export Citation Format

Share Document