Increased tritiated thymidine-labeling index of bone marrow myeloblasts following BCG administration in man

1978 ◽  
Vol 4 (3) ◽  
pp. 197-199
Author(s):  
M. Rozencweig ◽  
P. Stryckmans ◽  
J.P. Fichefet ◽  
Mireille Socquet
Keyword(s):  
Bone Marrow ◽  
Tritiated Thymidine ◽  
Labeling Index ◽  
Thymidine Labeling Index

Studies on3H-thymidine Labeling Index of Bone Marrow Cells in Various Childhood Disorders

1970 ◽  
Vol 12 (1) ◽  
pp. 39-41
Author(s):  
Yutaka Ueda ◽  
Keiji Ibuka ◽  
Masao Yamamoto ◽  
Masahiko Kuwabara ◽  
Yutaka Takahata
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Labeling Index ◽  
Childhood Disorders ◽  
Thymidine Labeling Index ◽  
Marrow Cells

scholarly journals Megakaryocytopoiesis in Experimental Iron Deficiency Anemia

Blood ◽  
1974 ◽  
Vol 43 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Sun I Choi ◽  
Joseph V. Simone ◽  
C. W. Jackson
Keyword(s):  
Iron Deficiency ◽  
Mitotic Index ◽  
Iron Deficiency Anemia ◽  
Tritiated Thymidine ◽  
Labeling Index ◽  
Deficiency Anemia ◽  
Platelet Production ◽  
Thymidine Labeling Index ◽  
Moderate Anemia ◽  
Immature Cells

Abstract Iron deficiency anemia is associated with increased platelet production. The megakaryocytic response to both moderate and severe iron deficiency anemia has been assessed in rats maintained on a low-iron diet. In animals with moderate anemia, the proportion of immature megakaryocytes and 24-hr tritiated thymidine labeling index were increased with no change in megakaryocyte concentration, size, or mitotic index. This indicates that increased platelet production is achieved by an increased rate of influx of precursor cells into the megakaryocyte compartment with an increased rate of efflux. In severe anemia, however, not only were the labeling index and the proportion of immature cells increased, but megakaryocyte size and mitotic index were significantly increased with a marked decrease in megakaryocyte concentration. This suggests that the circulating platelet mass is maintained by an increased platelet output per megakaryocyte with higher ploidy. Thus, in chronic iron deficiency anemia, megakaryocytopoiesis changes depending on the duration and degree of iron deficiency, with a more rapid turnover at first and increased polyploidy later.

Sequential assays of hormone receptors and the tritiated thymidine labeling index in 7,12-dimethylbenz(a)anthracene-induced rat mammary cancers

1985 ◽  
Vol 15 (2) ◽  
pp. 150-159 ◽  
Author(s):  
Keisuke Araki ◽  
Masaharu Kimura ◽  
Kiyoshi Sakamoto ◽  
Reiki Nishimura ◽  
Junichi Yamashita ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Tritiated Thymidine ◽  
Labeling Index ◽  
Thymidine Labeling Index

scholarly journals Kinetics of circulating B lymphocytes in human myeloma

Blood ◽  
1983 ◽  
Vol 61 (4) ◽  
pp. 812-814
Author(s):  
M Boccadoro ◽  
P Gavarotti ◽  
G Fossati ◽  
M Massaia ◽  
A Pileri ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Disease Activity ◽  
B Lymphocytes ◽  
Tritiated Thymidine ◽  
Kinetic Behavior ◽  
Excellent Correlation ◽  
Myeloma Cells ◽  
Thymidine Labeling Index ◽  
Kinetics Of ◽  
Normal Controls

The tritiated thymidine labeling index (LI%) of peripheral B lymphocytes was studied in eight myeloma patients using simultaneous immunofluorescence and autoradiography. The LI% values were low (0.3%- 5.1%), but significantly increased as compared to normal controls. In addition, there was excellent correlation between the LI% values and myeloma disease activity: lowest LI% values were observed in remission patients and the highest at the time of relapse. Simultaneous LI% evaluation of bone marrow myeloma cells in five patients gave concordant results, indicating the same kinetic behavior in both these compartments, particularly in the relapse phase. These data indicate both that circulating B lymphocytes include the neoplastic clone and that these B lymphocytes and bone marrow myeloma cells have similar kinetics.

scholarly journals Kinetics of circulating B lymphocytes in human myeloma

Blood ◽  
1983 ◽  
Vol 61 (4) ◽  
pp. 812-814 ◽  
Author(s):  
M Boccadoro ◽  
P Gavarotti ◽  
G Fossati ◽  
M Massaia ◽  
A Pileri ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Disease Activity ◽  
B Lymphocytes ◽  
Tritiated Thymidine ◽  
Kinetic Behavior ◽  
Excellent Correlation ◽  
Myeloma Cells ◽  
Thymidine Labeling Index ◽  
Kinetics Of ◽  
Normal Controls

Abstract The tritiated thymidine labeling index (LI%) of peripheral B lymphocytes was studied in eight myeloma patients using simultaneous immunofluorescence and autoradiography. The LI% values were low (0.3%- 5.1%), but significantly increased as compared to normal controls. In addition, there was excellent correlation between the LI% values and myeloma disease activity: lowest LI% values were observed in remission patients and the highest at the time of relapse. Simultaneous LI% evaluation of bone marrow myeloma cells in five patients gave concordant results, indicating the same kinetic behavior in both these compartments, particularly in the relapse phase. These data indicate both that circulating B lymphocytes include the neoplastic clone and that these B lymphocytes and bone marrow myeloma cells have similar kinetics.

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