Chromosomal localization of the human histamine H1-receptor gene

1994 ◽  
Vol 94 (2) ◽  
pp. 186-188 ◽  
Author(s):  
Maryvonne Le Coniat ◽  
Elisabeth Traiffort ◽  
Martial Ruat ◽  
Jean-Michel Arrang ◽  
Roland Berger
Keyword(s):  
Chromosomal Localization ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Human Histamine

Alternative Promoter Use and Splice Variation in the Human Histamine H1 Receptor Gene

2006 ◽  
Vol 35 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Caroline Swan ◽  
Susan A. Richards ◽  
Nathalie P. Duroudier ◽  
Ian Sayers ◽  
Ian P. Hall
Keyword(s):  
Receptor Gene ◽  
Alternative Promoter ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Splice Variation ◽  
Human Histamine

scholarly journals Structure of the human histamine H1 receptor gene

1998 ◽  
Vol 335 (3) ◽  
pp. 663-670 ◽  
Author(s):  
Marianne D. DE BACKER ◽  
Inge LOONEN ◽  
Peter VERHASSELT ◽  
Jean-Marc NEEFS ◽  
Walter H. M.L. LUYTEN
Keyword(s):  
G Protein ◽  
Untranslated Region ◽  
Receptor Gene ◽  
Promoter Sequence ◽  
Start Codon ◽  
Luciferase Reporter ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
G Protein Coupled ◽  
Human Histamine

Histamine H1 receptor expression has been reported to change in disorders such as allergic rhinitis, autoimmune myocarditis, rheumatoid arthritis and atherosclerosis. Here we report the isolation and characterization of genomic clones containing the 5´ flanking (regulatory) region of the human histamine H1 receptor gene. An intron of approx. 5.8 kb was identified in the 5´ untranslated region, which suggests that an entire subfamily of G-protein-coupled receptors may contain an intron immediately upstream of the start codon. The transcription initiation site was mapped by 5´ rapid amplification of cDNA ends to a region 6.2 kb upstream of the start codon. Immediately upstream of the transcription start site a fragment of 1.85 kb was identified that showed promoter activity when placed upstream of a luciferase reporter gene and transiently transfected into cells expressing the histamine H1 receptor. The promoter sequence shares a number of characteristics with the promoter sequences of other G-protein-coupled receptor encoding genes, including binding sites for several transcription factors, and the absence of TATA and CAAT sequences at the appropriate locations. The promoter sequence described here differs from that reported previously [Fukui, Fujimoto, Mizuguchi, Sakamoto, Horio, Takai, Yamada and Ito (1994) Biochem. Biophys. Res. Commun. 201, 894–901] because the reported genomic clone was chimaeric. Furthermore our study provides evidence that the 3´ untranslated region of the H1 receptor mRNA is much longer than previously accepted. Together, these findings provide a complete view of the structure of the human histamine H1 receptor gene. Both the coding region of the H1 receptor gene and its promoter region were independently mapped to chromosome 3p25.

Molecular Cloning of the Human Histamine H1 Receptor Gene

1994 ◽  
Vol 201 (2) ◽  
pp. 894-901 ◽  
Author(s):  
H. Fukui ◽  
K. Fujimoto ◽  
H. Mizuguchi ◽  
K. Sakamoto ◽  
Y. Horio ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Human Histamine

scholarly journals Molecular cloning of human histamine H1 receptor gene.

1993 ◽  
Vol 61 ◽  
pp. 88
Author(s):  
Hiroyuki Fukui ◽  
Hiroyuki Mizuguchi ◽  
Katsumi Fujimoto ◽  
Kazuichi Sakamoto ◽  
Masakatsu Yamashita ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Human Histamine

Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene

2021 ◽  
Author(s):  
Hiroyuki Mizuguchi ◽  
Yoshiaki Kitamura ◽  
Noriaki Takeda ◽  
Hiroyuki Fukui
Keyword(s):  
Transcriptional Regulation ◽  
Receptor Gene ◽  
Molecular Signaling ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals Molecular cloning of guinea-pig histamine H1 receptor gene.

1993 ◽  
Vol 61 ◽  
pp. 261
Author(s):  
Yoshiyuki Horio ◽  
Yasutake Mori ◽  
Katsumi Fujimoto ◽  
Seiji Ito ◽  
Hiroyuki Fukui
Keyword(s):  
Guinea Pig ◽  
Molecular Cloning ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals ANALYSIS OF PRIMARY STRUCTURE OF HUMAN HISTAMINE H1 RECEPTOR mRNA.

1996 ◽  
Vol 71 ◽  
pp. 70
Author(s):  
Katsumi Fujimoto ◽  
Kazuichi Sakamoto ◽  
Seiji Ito ◽  
Satoshi Ogino ◽  
Hiroyuki Fukui
Keyword(s):  
Primary Structure ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Receptor Mrna ◽  
Human Histamine

Production of the stable human histamine H1 receptor in Pichia pastoris for structural determination

Methods ◽  
2011 ◽  
Vol 55 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Mitsunori Shiroishi ◽  
Takuya Kobayashi ◽  
Satoshi Ogasawara ◽  
Hirokazu Tsujimoto ◽  
Chiyo Ikeda-Suno ◽  
...  
Keyword(s):  
Pichia Pastoris ◽  
Structural Determination ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Human Histamine
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