Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene

2021 ◽  
Author(s):  
Hiroyuki Mizuguchi ◽  
Yoshiaki Kitamura ◽  
Noriaki Takeda ◽  
Hiroyuki Fukui
Keyword(s):  
Transcriptional Regulation ◽  
Receptor Gene ◽  
Molecular Signaling ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals Transcriptional regulation of histamine H1 receptor gene by PMA and dexamethasone.

1994 ◽  
Vol 64 ◽  
pp. 301
Author(s):  
Katsumi Fujimoto ◽  
Ye Qi Liu ◽  
Kazuichi Sakamoto ◽  
Seiji Ito ◽  
Yoshiyuki Horio ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor

Chromosomal localization of the human histamine H1-receptor gene

1994 ◽  
Vol 94 (2) ◽  
pp. 186-188 ◽  
Author(s):  
Maryvonne Le Coniat ◽  
Elisabeth Traiffort ◽  
Martial Ruat ◽  
Jean-Michel Arrang ◽  
Roland Berger
Keyword(s):  
Chromosomal Localization ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Human Histamine

scholarly journals Molecular cloning of guinea-pig histamine H1 receptor gene.

1993 ◽  
Vol 61 ◽  
pp. 261
Author(s):  
Yoshiyuki Horio ◽  
Yasutake Mori ◽  
Katsumi Fujimoto ◽  
Seiji Ito ◽  
Hiroyuki Fukui
Keyword(s):  
Guinea Pig ◽  
Molecular Cloning ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor

Alternative Promoter Use and Splice Variation in the Human Histamine H1 Receptor Gene

2006 ◽  
Vol 35 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Caroline Swan ◽  
Susan A. Richards ◽  
Nathalie P. Duroudier ◽  
Ian Sayers ◽  
Ian P. Hall
Keyword(s):  
Receptor Gene ◽  
Alternative Promoter ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Splice Variation ◽  
Human Histamine

scholarly journals Signaling Pathway of Histamine H1 Receptor-Mediated Histamine H1 Receptor Gene Upregulation Induced by Histamine in U-373 MG Cells

2021 ◽  
Vol 43 (3) ◽  
pp. 1243-1254
Author(s):  
Hiroyuki Mizuguchi ◽  
Yuko Miyamoto ◽  
Takuma Terao ◽  
Haruka Yoshida ◽  
Wakana Kuroda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathway ◽  
Hela Cells ◽  
Time Course ◽  
Receptor Gene ◽  
Selective Inhibitor ◽  
H1 Receptor ◽  
Promoter Assay ◽  
Peripheral Tissues ◽  
Histamine H1 Receptor

Histamine H1 receptor (H1R) is one of the targets of histamine in the nervous system and the peripheral tissues. Protein kinase Cδ (PKCδ) signaling is involved in histamine-induced upregulation of H1R gene expression in HeLa cells. Histamine also upregulates H1R gene expression in U-373 MG cells. However, the molecular signaling of this upregulation is still unclear. Here, we investigated the molecular mechanism of histamine-induced H1R gene upregulation in U-373 MG cells. Histamine-induced H1R gene upregulation was inhibited by H1R antagonist d-chlorpheniramine, but not by ranitidine, ciproxifan, or JNJ77777120, and H2R, H3R, or H4R antagonists, respectively. Ro-31-8220 and Go6976 also suppressed this upregulation, however, the PKCδ selective inhibitor rottlerin and the PKCβ selective inhibitor Ly333531 did not. Time-course studies showed distinct kinetics of H1R gene upregulation in U-373 MG cells from that in HeLa cells. A promoter assay revealed that the promoter region responsible for H1R gene upregulation in U-373 MG cells was different from that of HeLa cells. These data suggest that the H1R-activated H1R gene expression signaling pathway in U-373 MG cells is different from that in HeLa cells, possibly by using different promoters. The involvement of PKCα also suggests that compounds that target PKCδ could work as peripheral type H1R-selective inhibitors without a sedative effect.

Molecular Cloning of the Guinea-Pig Histamine H1 Receptor Gene

1993 ◽  
Vol 114 (3) ◽  
pp. 408-414 ◽  
Author(s):  
Yoshiyuki Horio ◽  
Yasutake Mori ◽  
Ichiro Higuchi ◽  
Katsumi Fujimoto ◽  
Seiji Ito ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Molecular Cloning ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor

Characterization of histamine H1 receptor gene knocked-out mice

1998 ◽  
Vol 5 ◽  
pp. 218
Author(s):  
T. Watanabe ◽  
K. Yanai ◽  
T. Watanabe
Keyword(s):  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals Structure of the human histamine H1 receptor gene

1998 ◽  
Vol 335 (3) ◽  
pp. 663-670 ◽  
Author(s):  
Marianne D. DE BACKER ◽  
Inge LOONEN ◽  
Peter VERHASSELT ◽  
Jean-Marc NEEFS ◽  
Walter H. M.L. LUYTEN
Keyword(s):  
G Protein ◽  
Untranslated Region ◽  
Receptor Gene ◽  
Promoter Sequence ◽  
Start Codon ◽  
Luciferase Reporter ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
G Protein Coupled ◽  
Human Histamine

Histamine H1 receptor expression has been reported to change in disorders such as allergic rhinitis, autoimmune myocarditis, rheumatoid arthritis and atherosclerosis. Here we report the isolation and characterization of genomic clones containing the 5´ flanking (regulatory) region of the human histamine H1 receptor gene. An intron of approx. 5.8 kb was identified in the 5´ untranslated region, which suggests that an entire subfamily of G-protein-coupled receptors may contain an intron immediately upstream of the start codon. The transcription initiation site was mapped by 5´ rapid amplification of cDNA ends to a region 6.2 kb upstream of the start codon. Immediately upstream of the transcription start site a fragment of 1.85 kb was identified that showed promoter activity when placed upstream of a luciferase reporter gene and transiently transfected into cells expressing the histamine H1 receptor. The promoter sequence shares a number of characteristics with the promoter sequences of other G-protein-coupled receptor encoding genes, including binding sites for several transcription factors, and the absence of TATA and CAAT sequences at the appropriate locations. The promoter sequence described here differs from that reported previously [Fukui, Fujimoto, Mizuguchi, Sakamoto, Horio, Takai, Yamada and Ito (1994) Biochem. Biophys. Res. Commun. 201, 894–901] because the reported genomic clone was chimaeric. Furthermore our study provides evidence that the 3´ untranslated region of the H1 receptor mRNA is much longer than previously accepted. Together, these findings provide a complete view of the structure of the human histamine H1 receptor gene. Both the coding region of the H1 receptor gene and its promoter region were independently mapped to chromosome 3p25.

scholarly journals Stimulation of Histamine H1 Receptor Up-Regulates Histamine H1 Receptor Itself Through Activation of Receptor Gene Transcription

2007 ◽  
Vol 103 (4) ◽  
pp. 374-382 ◽  
Author(s):  
Asish K. Das ◽  
Sachiho Yoshimura ◽  
Ryoko Mishima ◽  
Katsumi Fujimoto ◽  
Hiroyuki Mizuguchi ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Receptor Gene ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Stimulation Of
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