Type C viruses: Natural derivatives of cellular genes involved in malignant transformation

1979 ◽  
Vol 2 (3) ◽  
Author(s):  
CharlesJ. Sherr ◽  
GeorgeJ. Todaro
Keyword(s):  
Malignant Transformation ◽  
Cellular Genes ◽  
Type C ◽  
Derivatives Of

scholarly journals Characterization of KPC-Encoding Plasmids from Enterobacteriaceae Isolated in a Czech Hospital

2017 ◽  
Vol 62 (3) ◽  
Author(s):  
Rudolf Kukla ◽  
Katerina Chudejova ◽  
Costas C. Papagiannitsis ◽  
Matej Medvecky ◽  
Katerina Habalova ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Type A ◽  
Type B ◽  
Content Type ◽  
Type C ◽  
Derivatives Of

ABSTRACT Ten Enterobacteriaceae isolates collected in a Czech hospital carried bla KPC -positive plasmids of different sizes (∼30, ∼45, and ∼80 kb). Sequencing revealed three types of plasmids (A to C) with the Tn 4401a transposon. Type A plasmids comprised an IncR backbone and a KPC-2-encoding multidrug resistance (MDR) region. Type B plasmids were derivatives of type A plasmids carrying an IncN3-like segment, while type C plasmids were IncP6 plasmids sharing the same KPC-2-encoding MDR region with type A and B plasmids.

Phenylation of Fullerene-C60

1994 ◽  
Vol 349 ◽  
Author(s):  
Roger Taylor ◽  
Anthony G. Avent ◽  
Paul R. Birkett ◽  
Jon C. Crane ◽  
Adam D. Darwish ◽  
...  
Keyword(s):  
Ferric Chloride ◽  
Fullerene C60 ◽  
Type C ◽  
Derivatives Of

ABSTRACTC60 Cl6 can be phenylated and arylated to give derivatives of the type C60Ar5Cl, which may be readily converted to C60Ar5. The compounds C60Ar5 and various other phenylated derivatives have been isolated from the product of reaction of [60]fullerene with bromine/ferric chloride/benzene, and partially characterised.

Molecular Biology of Human Oral Cancer

1996 ◽  
Vol 7 (4) ◽  
pp. 319-328 ◽  
Author(s):  
D.T.W. Wong ◽  
R. Todd ◽  
T. Tsuji ◽  
R.B. Donoff
Keyword(s):  
Cancer Research ◽  
Oral Cancer ◽  
Tumor Suppressor ◽  
Molecular Biology ◽  
Malignant Transformation ◽  
Tumor Suppressor Genes ◽  
Human Cancer ◽  
Transformation Process ◽  
Current Status ◽  
Cellular Genes

The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of human cancers, our understanding of human oral cancer lags behind that of cancer of other body sites. This review attempts to assess the current status of the molecular biology of human oral cancer.

N-Acetyl Derivatives of Type C Fumonisins Produced byFusariumoxysporum

1999 ◽  
Vol 62 (2) ◽  
pp. 355-357 ◽  
Author(s):  
Jeong-Ah Seo ◽  
Jin-Cheol Kim ◽  
Yin-Won Lee
Keyword(s):  
Type C ◽  
Derivatives Of

The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription

2017 ◽  
Vol 151 (2) ◽  
pp. 72-81
Author(s):  
Xianyao Zhou ◽  
Qiujun Liu ◽  
Da Wang ◽  
Xuemei Zhang ◽  
David W. Emery ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Transcription Termination ◽  
Retroviral Vector ◽  
Gene Sequences ◽  
Cellular Gene ◽  
Aberrant Splicing ◽  
Chromatin Insulator ◽  
Fusion Transcripts ◽  
Gene Dysregulation ◽  
Cellular Genes

Integrating gammaretroviral vectors can dysregulate the expression of cellular genes through a variety of mechanisms, leading to genotoxicity and malignant transformation. Although most attention has focused on the activation of cellular genes by vector enhancers, aberrant fusion transcripts involving cellular gene sequences and vector promoters, vector splice elements, and vector transcription termination sequences have also been mechanistically associated with dysregulated expression of cellular genes. Chromatin insulators have emerged as an effective tool for reducing the frequency of vector-mediated genotoxicity and malignant transformation and have been shown to block the activation of cellular genes by vector enhancers. We report here evidence that flanking a gammaretroviral reporter vector with the cHS4 chromatin insulator also reduces the frequency of vector-mediated cellular gene dysregulation associated with aberrant vector transcripts, including vector transcription run-through and aberrant splicing. We demonstrate that the cHS4 element does not function to terminate transcription directly, implicating other mechanisms for this activity.

Aminocyclophosphazene Derivatives of Tungsten Carbonyl

1999 ◽  
Vol 54 (12) ◽  
pp. 1543-1546
Author(s):  
A. K. Shrimal
Keyword(s):  
Mixed Ligand ◽  
Tungsten Carbonyl ◽  
Type C ◽  
Derivatives Of

Reactions of aminated cyclotri- and cyclotetra-phosphazenes, viz., N3P3L6 and N4P4L8 (L = -NC4H8O, -NC5H10, -HNC6H11 and -HNC8H17) with W(CO)6 have been studied. [(N3P3L6)W(CO)3] derivatives are obtained with N3P3L6 while N4P4L8 yield tetracarbonyl substituted derivatives, [(N4P4L8)W(CO)4]. Mixed ligand tungsten tricarbonyls of the type [C12H8N2)(N3P3L6 or N4P4L8)W(CO)3] have also been synthesized with [(o-phen)W(CO)4].

13C, 29Si, 115Sn, 117Sn and 119Sn NMR spectra of some triphenyl derivatives of elements of IVB group

1981 ◽  
Vol 46 (6) ◽  
pp. 1383-1388 ◽  
Author(s):  
Antonín Lyčka ◽  
Dobroslav Šnobl ◽  
Karel Handlíř ◽  
Jaroslav Holeček ◽  
Milan Nádvorník
Keyword(s):  
Nmr Spectra ◽  
Chemical Shifts ◽  
Coupling Constants ◽  
119Sn Nmr ◽  
Type C ◽  
Derivatives Of

13C, 29Si and Sn NMR spectra of ten compounds type (C6H5)3XY, four compounds type ((C6H5)3XO)2CrO2 and - for comparison - two compounds type (CH3CH2CH2CH2)3SnY and ((CH3CH2CH2CH2)3SnO)2CrO2 (X are elements of IVB group) have been measured in deuteriochloroform. The respective chemical shifts, absolute values of coupling constants nJ(119Sn13C) and 2J(119Sn117Sn) are given.

Fragmentation and rearrangement processes in the mass spectra of perhalogenoaromatic compounds. Part II. Pentafluorophenyl derivatives of GroupIV

1969 ◽  
Vol 47 (10) ◽  
pp. 1613-1620 ◽  
Author(s):  
J. M. Miller
Keyword(s):  
Mass Spectra ◽  
Central Atom ◽  
Metal Fluoride ◽  
Fluoride Ions ◽  
Bond Forming ◽  
Central Carbon ◽  
Type C ◽  
Derivatives Of ◽  
Rearrangement Processes ◽  
Neutral Metal

The mass spectra of compounds of the type (C6F5)4M (M = Si, Ge, Sn, and Pb) have been studied. Bond forming rearrangements were detected, involving fluorine abstraction by the central atom, forming perfluorophenylene ions and neutral metal fluoride species. The heavier metals give simpler spectra and fragmentation schemes. The bulk of the ion current is carried by fluorocarbon ions for the silicon derivative and by organometallic or metal fluoride ions in the other three cases, SnF+ and PbF+ forming the base peaks in their spectra. When M is carbon in the compounds (C6F5)3COH and (C6F5)2CO, there is little evidence for rearrangements and transfer of fluorine to the central carbon atom.

Biological and Surface Properties of C-Type Virus Particles Produced by Novikoff Ascites Hepatoma Cells

1977 ◽  
Vol 35 ◽  
pp. 388-389
Author(s):  
D.C. Hixson ◽  
J.C. Chan ◽  
J.M. Bowen ◽  
E.F. Walborg
Keyword(s):  
Surface Properties ◽  
Ricinus Communis ◽  
Rat Kidney ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
Virus Particles ◽  
Chemically Induced ◽  
Sarcoma Virus ◽  
Hepatocarcinoma Cells ◽  
Type C

Several years ago Karasaki (1) reported the production of type C virus particles by Novikoff ascites hepatocarcinoma cells. More recently, Weinstein (2) has reported the presence of type C virus particles in cell cultures derived from transplantable and primary hepatocellular carcinomas. To date, the biological function of these virus and their significance in chemically induced hepatocarcinogenesis are unknown. The present studies were initiated to determine a possible role for type C virus particles in chemically induced hepatocarcinogenesis. This communication describes results of studies on the biological and surface properties of type C virus associated with Novikoff hepatocarcinoma cells.Ecotropic and xenotropic murine leukemia virus (MuLV) activity in ascitic fluid of Novikoff tumor-bearing rats was assayed in murine sarcoma virus transformed S+L- mouse cells and S+L- mink cells, respectively. The presence of sarcoma virus activity was assayed in non-virus-producing normal rat kidney (NRK) cells. Ferritin conjugates of concanavalin A (Fer-Con wheat germ agglutinin (Fer-WGA), and Ricinus communis agglutinins I and II (Fer-RCAI and Fer-RCAII) were used to probe the structure and topography of saccharide determinants present on the viral envelope.

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