Ultrastructural localization of tissue factor on monocyte-derived macrophages and macrophage foam cells associated with atherosclerotic lesions

1994 ◽  
Vol 425 (1) ◽  
Author(s):  
S.C. Landers ◽  
M. Gupta ◽  
J.C. Lewis
Keyword(s):  
Tissue Factor ◽  
Ultrastructural Localization ◽  
Foam Cells ◽  
Atherosclerotic Lesions ◽  
Macrophage Foam Cells

scholarly journals SCAVENGER RECEPTOR-MEDIATED TARGETING OF MACROPHAGE FOAM CELLS IN ATHEROSCLEROTIC PLAQUE USING OLIGONUCLEOTIDE-FUNCTIONALIZED NANOPARTICLES

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 207-214 ◽  
Author(s):  
GAURAV SHARMA ◽  
ZHI-GANG SHE ◽  
DAVID T. VALENTA ◽  
WILLIAM B. STALLCUP ◽  
JEFFREY W. SMITH
Keyword(s):  
Atherosclerotic Plaque ◽  
Plaque Rupture ◽  
Ex Vivo ◽  
Scavenger Receptor ◽  
Foam Cells ◽  
Scavenger Receptors ◽  
Atherosclerotic Lesions ◽  
Macrophage Foam Cells ◽  
Progression Of Disease

Macrophage foam cells are key components of atherosclerotic plaque and play an important role in the progression of atherosclerosis leading to plaque rupture and thrombosis. Foam cells are emerging as attractive targets for therapeutic intervention and imaging the progression of disease. Therefore, designing nanoparticles (NPs) targeted to macrophage foam cells in plaque is of considerable therapeutic significance. Here we report the construction of an oligonucleotide-functionalized NP system with high affinity for foam cells. Nanoparticles functionalized with a 23-mer poly-Guanine (polyG) oligonucleotide are specifically recognized by the scavenger receptors on lipid-laden foam cells in vitro and ex vivo. The enhanced uptake of polyG-functionalized NPs by foam cells is inhibited in the presence of acetylated-LDL, a known ligand of scavenger receptors. Since polyG oligonucleotides are stable in serum and are unlikely to induce an immune response, they are a promising candidate for developing an NP platform for scavenger receptor-mediated targeting of macrophages that can be optimized for targeting foam cells in atherosclerotic lesions.

Macrophage foam cells and atherosclerosis

10.2741/kruth ◽  
2001 ◽  
Vol 6 (1) ◽  
pp. d429 ◽  
Author(s):  
Howard, S. Kruth
Keyword(s):  
Foam Cells ◽  
Macrophage Foam Cells

scholarly journals Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells

1993 ◽  
Vol 268 (13) ◽  
pp. 9653-9660
Author(s):  
R.K. Tangirala ◽  
F.H. Mahlberg ◽  
J.M. Glick ◽  
W.G. Jerome ◽  
G.H. Rothblat
Keyword(s):  
Foam Cells ◽  
Unesterified Cholesterol ◽  
Macrophage Foam Cells ◽  
Lysosomal Accumulation

Identification of novel lipid droplet factors that regulate autophagy and cholesterol efflux in macrophage foam cells

2021 ◽  
Vol 331 ◽  
pp. e2
Author(s):  
S. Robichaud ◽  
G. Fairman ◽  
V. Vijithakumar ◽  
E. Mak ◽  
D. Cook ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Cholesterol Efflux ◽  
Foam Cells ◽  
Macrophage Foam Cells
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