Resveratrol Derivative, Trans ‐3, 5, 4′‐Trimethoxystilbene, Prevents the Developing of Atherosclerotic Lesions and Attenuates Cholesterol Accumulation in Macrophage Foam Cells

2020 ◽  
Vol 64 (6) ◽  
pp. 1901115 ◽  
Author(s):  
Ming Hong ◽  
Jinke Li ◽  
Siying Li ◽  
Mohammed M. Almutairi
Keyword(s):  
Foam Cells ◽  
Cholesterol Accumulation ◽  
Atherosclerotic Lesions ◽  
Macrophage Foam Cells ◽  
Resveratrol Derivative

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

2012 ◽  
Vol 56 (5) ◽  
pp. 691-701 ◽  
Author(s):  
Jing-Feng Zhao ◽  
Li-Chieh Ching ◽  
Yu-Chu Huang ◽  
Chien-Yu Chen ◽  
An-Na Chiang ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Foam Cells ◽  
Cholesterol Accumulation ◽  
Macrophage Foam Cells

scholarly journals SCAVENGER RECEPTOR-MEDIATED TARGETING OF MACROPHAGE FOAM CELLS IN ATHEROSCLEROTIC PLAQUE USING OLIGONUCLEOTIDE-FUNCTIONALIZED NANOPARTICLES

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 207-214 ◽  
Author(s):  
GAURAV SHARMA ◽  
ZHI-GANG SHE ◽  
DAVID T. VALENTA ◽  
WILLIAM B. STALLCUP ◽  
JEFFREY W. SMITH
Keyword(s):  
Atherosclerotic Plaque ◽  
Plaque Rupture ◽  
Ex Vivo ◽  
Scavenger Receptor ◽  
Foam Cells ◽  
Scavenger Receptors ◽  
Atherosclerotic Lesions ◽  
Macrophage Foam Cells ◽  
Progression Of Disease

Macrophage foam cells are key components of atherosclerotic plaque and play an important role in the progression of atherosclerosis leading to plaque rupture and thrombosis. Foam cells are emerging as attractive targets for therapeutic intervention and imaging the progression of disease. Therefore, designing nanoparticles (NPs) targeted to macrophage foam cells in plaque is of considerable therapeutic significance. Here we report the construction of an oligonucleotide-functionalized NP system with high affinity for foam cells. Nanoparticles functionalized with a 23-mer poly-Guanine (polyG) oligonucleotide are specifically recognized by the scavenger receptors on lipid-laden foam cells in vitro and ex vivo. The enhanced uptake of polyG-functionalized NPs by foam cells is inhibited in the presence of acetylated-LDL, a known ligand of scavenger receptors. Since polyG oligonucleotides are stable in serum and are unlikely to induce an immune response, they are a promising candidate for developing an NP platform for scavenger receptor-mediated targeting of macrophages that can be optimized for targeting foam cells in atherosclerotic lesions.

Andrographolide Inhibits Oxidized LDL-Induced Cholesterol Accumulation and Foam Cell Formation in Macrophages

2018 ◽  
Vol 46 (01) ◽  
pp. 87-106 ◽  
Author(s):  
Hung-Chih Lin ◽  
Chong-Kuei Lii ◽  
Hui-Chun Chen ◽  
Ai-Hsuan Lin ◽  
Ya-Chen Yang ◽  
...  
Keyword(s):  
Protein Expression ◽  
Foam Cell ◽  
Cell Formation ◽  
Foam Cells ◽  
Foam Cell Formation ◽  
Cholesterol Accumulation ◽  
Macrophage Foam Cell ◽  
Macrophage Foam Cells ◽  
Mrna And Protein Expression ◽  
Anti Inflammatory

oxLDL is involved in the pathogenesis of atherosclerotic lesions through cholesterol accumulation in macrophage foam cells. Andrographolide, the bioactive component of Andrographis paniculata, possesses several biological activities such as anti-inflammatory, anti-oxidant, and anticancer functions. Scavenger receptors (SRs), including class A SR (SR-A) and CD36, are responsible for the internalization of oxLDL. In contrast, receptors for reverse cholesterol transport, including ABCA1 and ABCG1, mediate the efflux of cholesterol from macrophage foam cells. Transcription factor liver X receptor [Formula: see text] (LXR[Formula: see text] plays a key role in lipid metabolism and inflammation as well as in the regulation of ABCA1 and ABCG1 expression. Because of the contribution of inflammation to macrophage foam cell formation and the potent anti-inflammatory activity of andrographolide, we hypothesized that andrographolide might inhibit oxLDL-induced macrophage foam cell formation. The results showed that andrographolide reduced oxLDL-induced lipid accumulation in macrophage foam cells. Andrographolide decreased the mRNA and protein expression of CD36 by inducing the degradation of CD36 mRNA; however, andrographolide had no effect on SR-A expression. In contrast, andrographolide increased the mRNA and protein expression of ABCA1 and ABCG1, which were dependent on LXR[Formula: see text]. Andrographolide enhanced LXR[Formula: see text] nuclear translocation and DNA binding activity. Treatment with the LXR[Formula: see text] antagonist GGPP and transfection with LXR[Formula: see text] siRNA reversed the ability of andrographolide to stimulate ABCA1 and ABCG1 protein expression. In conclusion, inhibition of CD36-mediated oxLDL uptake and induction of ABCA1- and ABCG1-dependent cholesterol efflux are two working mechanisms by which andrographolide inhibits macrophage foam cell formation, which suggests that andrographolide could be a potential candidate to prevent atherosclerosis.

Macrophage foam cells and atherosclerosis

10.2741/kruth ◽  
2001 ◽  
Vol 6 (1) ◽  
pp. d429 ◽  
Author(s):  
Howard, S. Kruth
Keyword(s):  
Foam Cells ◽  
Macrophage Foam Cells
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