Expression of antigens related to apoptosis and cell proliferation in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis

1996 ◽  
Vol 429-429 (2-3) ◽  
Author(s):  
T. Kuroki ◽  
S. Seki ◽  
N. Kawakita ◽  
K. Nakatani ◽  
T. Kitada ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Chronic Nonsuppurative Destructive Cholangitis

scholarly journals SNP Analysis of Genes Implicated in T Cell Proliferation in Primary Biliary Cirrhosis

2005 ◽  
Vol 12 (4) ◽  
pp. 259-263 ◽  
Author(s):  
Sabine Oertelt ◽  
Thomas P. Kenny ◽  
Carlo Selmi ◽  
Pietro Invernizzi ◽  
Mauro Podda ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Primary Biliary Cirrhosis ◽  
T Cell Proliferation ◽  
Biliary Cirrhosis ◽  
Snp Analysis

scholarly journals Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Causative Factor ◽  
Biliary Cirrhosis ◽  
Novel Approach ◽  
Bile Duct Damage ◽  
Chronic Nonsuppurative Destructive Cholangitis ◽  
Bile Duct Lesions

Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.

scholarly journals Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis

Hepatology ◽  
2012 ◽  
Vol 55 (3) ◽  
pp. 846-855 ◽  
Author(s):  
Toru Takahashi ◽  
Tomofumi Miura ◽  
Junichiro Nakamura ◽  
Satoshi Yamada ◽  
Tsutomu Miura ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Plasma Cells ◽  
Biliary Cirrhosis ◽  
Chronic Nonsuppurative Destructive Cholangitis

Primary biliary cirrhosis

1970 ◽  
Vol 102 (2) ◽  
pp. 228-229 ◽  
Author(s):  
A. N. Domonkos
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis

Clincal effect of long-term (32 weeks) eicosapentate administation in primary biliary cirrhosis

2001 ◽  
Vol 120 (5) ◽  
pp. A355-A355
Author(s):  
K TAKAGI ◽  
M TAKAHASHI ◽  
H TAKADA ◽  
Y KITAZUMI ◽  
T ARIMA ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis

Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis

2000 ◽  
Vol 33 (4) ◽  
pp. 528-536 ◽  
Author(s):  
Isabel Mayo ◽  
Paz Arizti ◽  
Albert Pares ◽  
Joaquin Oliva ◽  
Rita Alvarez Doforno ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Terminal Region ◽  
Biliary Cirrhosis ◽  
E Coli
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