scholarly journals Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis

Hepatology ◽  
2012 ◽  
Vol 55 (3) ◽  
pp. 846-855 ◽  
Author(s):  
Toru Takahashi ◽  
Tomofumi Miura ◽  
Junichiro Nakamura ◽  
Satoshi Yamada ◽  
Tsutomu Miura ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Plasma Cells ◽  
Biliary Cirrhosis ◽  
Chronic Nonsuppurative Destructive Cholangitis

scholarly journals Immunostaining of Plasma Cells in Primary Biliary Cirrhosis

2009 ◽  
Vol 131 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Jason A. Daniels ◽  
Michael Torbenson ◽  
Robert A. Anders ◽  
John K. Boitnott
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Plasma Cells ◽  
Biliary Cirrhosis

S1870 Clinical Significance of Cd38-Positive Plasma Cells Surrounding Interlobular Bile Ducts in Primary Biliary Cirrhosis (PBC)

2010 ◽  
Vol 138 (5) ◽  
pp. S-807
Author(s):  
Toru Takahashi ◽  
Tomofumi Miura ◽  
Junichiro Nakamura ◽  
Satoshi Yamada ◽  
Tsutomu Miura ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Clinical Significance ◽  
Bile Ducts ◽  
Plasma Cells ◽  
Biliary Cirrhosis

Portal inflammation with plasma cells as a marker of recurrent primary biliary cirrhosis after liver transplantion

2000 ◽  
Vol 118 (4) ◽  
pp. A1492
Author(s):  
Pamela B. Sylvestre ◽  
Kenneth P. Batts ◽  
John J. Poterucha ◽  
Lawrence J. Burgart
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Plasma Cells ◽  
Biliary Cirrhosis

scholarly journals Hepatic nodular lymphoid lesion with increased IgG4-positive plasma cells associated with primary biliary cirrhosis: a report of two cases

2015 ◽  
Vol 467 (5) ◽  
pp. 613-617 ◽  
Author(s):  
Jessica Calvo ◽  
Nicolas Carbonell ◽  
Olivier Scatton ◽  
Christophe Marzac ◽  
Nathalie Ganne-Carrie ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Plasma Cells ◽  
Biliary Cirrhosis

Chronic Lymphocytic Cholangitis in Three Cats

1982 ◽  
Vol 19 (2) ◽  
pp. 99-108 ◽  
Author(s):  
K. W. Prasse ◽  
E. A. Mahaffey ◽  
R. DeNovo ◽  
L. Cornelius
Keyword(s):  
Plasma Cells ◽  
Serum Alkaline Phosphatase ◽  
Clinical Findings ◽  
Biliary Cirrhosis ◽  
Serum Alkaline Phosphatase Activity ◽  
Lymphoid Aggregate ◽  
Chronic Nonsuppurative Destructive Cholangitis ◽  
Clinical Illness ◽  
Hepatic Lesions ◽  
Lymphoid Aggregates

Wedge biopsy of the liver during episodic clinical illness in three male cats showed chronic lymphocytic cholangitis. Principal clinical findings were increased serum alkaline phosphatase activity and hepatomegaly (two cats) associated with anorexia, pyrexia, and weight loss; these signs of illness were intermittent with asymptomatic periods. The hepatic lesions were characterized by lymphoid aggregate or follicle formation, diffusely dispersed lymphocytes and plasma cells, and abnormal bile ducts and ductules. Lymphoid aggregates and diffusely scattered lymphocytes were seen in the pancreas also. The spectrum of hepatic lesions in three cats seemed to represent a progression in the development of the disease. Similarities and dissimilarities between the findings in the three cats and human primary biliary cirrhosis or chronic nonsuppurative destructive cholangitis are discussed. During a prospective search for cats with this disease, other hepatic lesions were found, and it was concluded that cats may be affected by more than one pathogenic mechanism culminating in chronic cholangitis or cholangiohepatitis.

scholarly journals Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Primary Biliary Cirrhosis ◽  
Cellular Senescence ◽  
Bile Ducts ◽  
Causative Factor ◽  
Biliary Cirrhosis ◽  
Novel Approach ◽  
Bile Duct Damage ◽  
Chronic Nonsuppurative Destructive Cholangitis ◽  
Bile Duct Lesions

Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. The autoimmune-mediated pathogenesis of bile duct lesions, including the significance of AMAs, triggers of the autoimmune process, and so on remain unclear. We have reported that cellular senescence in biliary epithelial cells (BECs) may be involved in bile duct lesions and that autophagy may precede the process of biliary epithelial senescence in PBC. Interestingly, BECs in damaged bile ducts show characteristicsof cellular senescence and autophagy in PBC. A suspected causative factor of biliary epithelial senescence is oxidative stress. Furthermore, senescent BECs may modulate the microenvironment around bile ducts by expressing various chemokines and cytokines called senescence-associated secretory phenotypes and contribute to the pathogenesis in PBC.

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