Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients

1994 ◽  
Vol 425 (4) ◽  
Author(s):  
F. Sessa ◽  
E. Solcia ◽  
C. Capella ◽  
M. Bonato ◽  
A. Scarpa ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Tumour Cell ◽  
Pancreatic Neoplasms ◽  
Distinct Group ◽  
Mucinous Tumours

Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma

2004 ◽  
Vol 30 (5) ◽  
pp. 513-521 ◽  
Author(s):  
U. Schüller ◽  
F. Schober ◽  
H. A. Kretzschmar ◽  
J. Herms
Keyword(s):  
Cell Differentiation ◽  
Tumour Cell

scholarly journals Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma.

1996 ◽  
Vol 49 (2) ◽  
pp. 134-138 ◽  
Author(s):  
Y Shoji ◽  
M Saegusa ◽  
Y Takano ◽  
M Ohbu ◽  
I Okayasu
Keyword(s):  
Cell Differentiation ◽  
Cervical Carcinoma ◽  
Tumour Cell ◽  
Hpv Infection

Alkylformamides as inducers of tumour cell differentiation — a mini-review

Toxicology ◽  
1987 ◽  
Vol 43 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Simon P. Langdon ◽  
John A. Hickman
Keyword(s):  
Cell Differentiation ◽  
Tumour Cell

scholarly journals In situApoptotic and Proliferation Index in Laryngeal Squamous Cell Carcinomas

1998 ◽  
Vol 16 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Hjalmar G. Hagedorn ◽  
Jutta Tübel ◽  
Irmgard Wiest ◽  
Andreas G. Nerlich
Keyword(s):  
Cell Proliferation ◽  
Cell Differentiation ◽  
Tumour Cell ◽  
Tumour Growth ◽  
Proliferation Index ◽  
Strong Increase ◽  
Tumour Stroma ◽  
Ki 67 ◽  
Laryngeal Mucosa ◽  
Proliferation And Apoptosis

The rate of cellular growth is mainly influenced by the balance between cell proliferation and cellular decay. Since to our knowledge, no study so far has analysed the rate of proliferation and apoptosis in the normal laryngeal mucosa and in invasive laryngeal carcinomas, we performed a morphological analysis on both parameters in biopsies from 30 patients with laryngeal carcinoma. We applied the TUNEL end labelling technique for the investigation of apoptosis and immunohistochemistry (Ki‐67 antigen) for the determination of the cell proliferation.In our study we demonstrated that invasive tumour growth of the larynx coincides with an increase of both cellular proliferation and apoptosis. Both parameters, however, affected various tumour areas differently. While there was a preferential expression of the Ki‐67 antigen at the tumour–stroma interface, apoptotic figures could be found randomly distributed in the tumour. This indicates that the replication of tumour cells and tumour cell decay are differently distributed and possibly independently regulated. Since we observed a particularly strong increase of cell proliferation at the tumour–stroma interface which outnumbered the corresponding rate of apoptosis by far, the enhanced cell proliferation at the tumour border seems to be a main factor for tumour growth.A statistical evaluation revealed significant correlation between the apoptotic index and the degree of tumour cell differentiation, indicating that a high rate of apoptosis coincides with a high level of tumour cell differentiation.There was, however, no statistically significant correlation between prognostic clinical parameters and the rate of apoptosis or that of proliferation.

CEA-immunoscintigraphy with 99m-technetium correlates with tumour cell differentiation in colorectal cancer

1993 ◽  
Vol 29 (9) ◽  
pp. 1327-1329
Author(s):  
Bianca M Wittig ◽  
Anja Hach ◽  
Klaus Hahn ◽  
Karl-Hermann Meyer zum Büschenfelde ◽  
Wolfgang G Dippold
Keyword(s):  
Colorectal Cancer ◽  
Cell Differentiation ◽  
Tumour Cell

Electron microscope study of the secretory activity of epithelial cells in embryonic thymus

1990 ◽  
Vol 48 (3) ◽  
pp. 382-383
Author(s):  
H. Alasam
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Epithelial Cells ◽  
Electron Density ◽  
Secretory Activity ◽  
T Cell Differentiation ◽  
High Electron ◽  
Transmission Electron ◽  
Medullary Epithelial Cells ◽  
Thymic Factor

The possibility that intrathymic T-cell differentiation involves stem cell-lymphoid interactions in embryos led us to study the ultrastructure of epithelial cell in normal embryonic thymus. Studies in adult thymus showed that it produces several peptides that induce T-cell differentiation. Several of them have been chemically characterized, such as thymosin α 1, thymopoietin, thymic humoral factor or the serum thymic factor. It was suggested that most of these factors are secreted by populations of A and B-epithelial cells.Embryonic materials were obtained from inbred matings of Swiss Albino mice. Thymuses were disected from embryos 17 days old and prepared for transmission electron microscopy. Our studies showed that embryonic thymus at this stage contains undifferentiated and differentiated epithelial cells, large lymphoblasts, medium and few small lymphocytes (Fig. 5). No differences were found between cortical and medullary epithelial cells, in contrast to the findings of Van Vliet et al,. Epithelial cells were mostly of the A-type with low electron density in both cytoplasm and nucleus. However few B-type with high electron density were also found (Fig. 7).

Role of CD5 expression on TCRγδ T cell-differentiation and development of chronic intestinal inflammation

2001 ◽  
Vol 120 (5) ◽  
pp. A517-A517
Author(s):  
A MIZOGUCHI ◽  
E MIZOGUCHI ◽  
Y DEJONG ◽  
H TAKEDATSU ◽  
F PREFFER ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Intestinal Inflammation ◽  
T Cell Differentiation ◽  
Chronic Intestinal Inflammation
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