Circulating intercellular adhesion molecule 1 as a new activity marker in patients with systemic lupus erythematosus

1993 ◽  
Vol 71 (4) ◽  
Author(s):  
E. Kling ◽  
S. Bieg ◽  
M. Boehme ◽  
W.A. Scherbaum
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Adhesion Molecule ◽  
Lupus Erythematosus ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Systemic Lupus ◽  
Activity Marker

Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus

Lupus ◽  
2005 ◽  
Vol 14 (3_suppl) ◽  
pp. 17-26 ◽  
Author(s):  
MJ Lewis ◽  
D D'Cruz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mycophenolate Mofetil ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Lupus Erythematosus ◽  
Cell Adhesion Molecules ◽  
Intercellular Adhesion Molecule ◽  
Lymphocyte Function ◽  
Systemic Lupus

Mycophenolate mofetil (MMF) has been reproducibly shown to inhibit lymphocyte adhesion and penetration of endothelial cell surfaces. The mechanism is not yet elucidated. In vitro studies on the effects of MMF on cell adhesion molecules (CAM) using human umbilical vein endothelial cells (HUVEC) have shown conflicting results. Different studies have independently shown that MMF increased, decreased or had no effect on intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1). Several studies suggest MMF may reduce the endothelial expression of E-selectin. Recent studies have been unable to replicate initial work, which suggested that MMF impaired glycosylation of lymphocyte CAM. The same studies concluded that MMF had no effect on the surface expression of lymphocyte CAM, but altered the binding ability of these molecules. ICAM-1/LFA-1 (lymphocyte function-associated antigen-1), VCAM-1/VLA-4 (very late antigen-4) and P-selectin/PSGL-1 (P-selectin glycoprotein ligand-1) ligand pairs are most likely to be involved. Few in vivo and no conclusive human studies have been carried out. The literature relevant to cell adhesion molecules in systemic lupus erythematosus (SLE) is reviewed in detail.

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