Absolute quantitation of gallium-67 citrate accumulation in the lungs and its importance for the evaluation of disease activity in pulmonary sarcoidosis

1992 ◽  
Vol 19 (12) ◽  
pp. 1016-1022 ◽  
Author(s):  
M. Mysliveček ◽  
V. Hušák ◽  
V. Kolek ◽  
M. Budíková ◽  
P. Koranda
Keyword(s):  
Disease Activity ◽  
Pulmonary Sarcoidosis ◽  
Absolute Quantitation ◽  
Citrate Accumulation ◽  
Gallium 67

Pulmonary sarcoidosis: role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment.

Radiology ◽  
1994 ◽  
Vol 191 (3) ◽  
pp. 675-680 ◽  
Author(s):  
M Remy-Jardin ◽  
F Giraud ◽  
J Remy ◽  
L Wattinne ◽  
B Wallaert ◽  
...  
Keyword(s):  
Disease Activity ◽  
Functional Impairment ◽  
Pulmonary Sarcoidosis

Gallium 67 accumulation in pulmonary sarcoidosis

JAMA ◽  
1973 ◽  
Vol 223 (6) ◽  
pp. 688-688 ◽  
Author(s):  
K. A. McKusick
Keyword(s):  
Pulmonary Sarcoidosis ◽  
Gallium 67

scholarly journals Increased serum YKL-40 in patients with pulmonary sarcoidosis—a potential marker of disease activity?

2005 ◽  
Vol 99 (4) ◽  
pp. 396-402 ◽  
Author(s):  
Julia S. Johansen ◽  
Nils Milman ◽  
Michael Hansen ◽  
Charly Garbarsch ◽  
Paul A. Price ◽  
...  
Keyword(s):  
Disease Activity ◽  
Pulmonary Sarcoidosis ◽  
Potential Marker

scholarly journals CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis

Thorax ◽  
2016 ◽  
Vol 71 (12) ◽  
pp. 1161-1163 ◽  
Author(s):  
Rachel Benamore ◽  
Yvonne R Kendrick ◽  
Emmanouela Repapi ◽  
Emma Helm ◽  
Suzanne L Cole ◽  
...  
Keyword(s):  
Disease Activity ◽  
Pulmonary Sarcoidosis

67Ga scintigraphy as an index of disease activity in pulmonary sarcoidosis

1981 ◽  
Vol 6 (5) ◽  
pp. 205-212 ◽  
Author(s):  
Chr. Alberts ◽  
J. B. van der Schoot ◽  
A. S. Groen
Keyword(s):  
Disease Activity ◽  
Pulmonary Sarcoidosis ◽  
67Ga Scintigraphy

scholarly journals 99mTc-anti-TNF-α antibody for the imaging of disease activity in pulmonary sarcoidosis

2016 ◽  
Vol 47 (4) ◽  
pp. 1198-1207 ◽  
Author(s):  
Roeland Vis ◽  
Gaurav Malviya ◽  
Alberto Signore ◽  
Jan C. Grutters ◽  
Bob Meek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Function ◽  
Disease Activity ◽  
Pulmonary Sarcoidosis ◽  
Emission Computed Tomography ◽  
Target Tissue ◽  
Laboratory Parameters ◽  
Tissue Accumulation ◽  
Pet Ct ◽  
Tnf Α

Infliximab, a monoclonal antibody directed against tumour necrosis factor (TNF)-α, is used in the treatment of refractory sarcoidosis. However, the clinical response is variable and a tool to select responders beforehand is highly desirable. In this study we evaluated scintigraphy with technetium-99m (99mTc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis.10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of 99mTc-infliximab. Correlation analysis was performed between tissue accumulation of 99mTc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffusing capacity of the lung for carbon monoxide) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT.Analysis showed selective and variable accumulation of 99mTc-infliximab in the target tissue. Accumulation correlated positively with all four laboratory parameters and negatively with all four lung function parameters, yielding better correlations than serum TNF-α levels or 18F-FDG PET/CT.99mTc-infliximab accumulation reflects the in situ TNF-α expression in an individual patient and therefore provides valuable information on the presence of the biological target for anti-TNF-α therapy.

scholarly journals Pulmonary sarcoidosis: excess of helper T lymphocytes and T cell subset imbalance at sites of disease activity.

Thorax ◽  
1984 ◽  
Vol 39 (2) ◽  
pp. 143-149 ◽  
Author(s):  
G A Rossi ◽  
O Sacco ◽  
E Cosulich ◽  
G Damiani ◽  
G Corte ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Disease Activity ◽  
Cell Subset ◽  
Pulmonary Sarcoidosis ◽  
T Cell Subset ◽  
Helper T Lymphocytes
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