Neurogenic chloride secretion induced by scorpion venom and veratrine in rabbit colon

1994 ◽  
Vol 350 (4) ◽  
Author(s):  
Herbert Plass ◽  
Christoph Wachter ◽  
Klaus Turnheim
Keyword(s):  
Chloride Secretion ◽  
Scorpion Venom ◽  
Rabbit Colon

AlF 4 ? and vanadate stimulate chloride secretion in rabbit colon by a Ca2+-dependent mechanism

1992 ◽  
Vol 420 (5-6) ◽  
pp. 515-521 ◽  
Author(s):  
J. S. Jung ◽  
T. H. Hwang ◽  
D. K. Jung ◽  
Y. K. Kim ◽  
S. H. Lee
Keyword(s):  
Chloride Secretion ◽  
Rabbit Colon ◽  
Dependent Mechanism

Effects of scorpion venom on electrolyte transport by rabbit ileum

1983 ◽  
Vol 244 (5) ◽  
pp. G501-G506 ◽  
Author(s):  
K. A. Hubel
Keyword(s):  
Ion Transport ◽  
Short Circuit ◽  
Muscularis Propria ◽  
Short Circuit Current ◽  
Chloride Secretion ◽  
Scorpion Venom ◽  
Tissue Response ◽  
Flux Chamber ◽  
Rabbit Ileum ◽  
Batch Number

Scorpion venom, which depolarizes nerves, was used to obtain further evidence that intramural nerves affect ion transport by the rabbit ileum. Ileal epithelium, stripped of muscularis propria, was mounted in a flux chamber modified to permit electrical field stimulation (EFS) of the tissue. Response of the short-circuit current (Isc) to venom was most rapid on the serosal surface, and the response was eliminated by tetrodotoxin. Isc response was influenced by venom batch number and by factors within the tissue. Venom (10 micrograms/ml) and EFS each caused chloride secretion by reducing mucosal-to-serosal movement and by increasing serosal-to-mucosal movement. Sodium transport and residual ion fluxes did not change. In the presence of venom, EFS caused no further changes in ion transport, but tissues still responded to glucose and to aminophylline. The early peak of Isc was reduced about 40% by atropine, implying that acetylcholine, released by venom, stimulates muscarinic receptors. The blockade of the Isc response to venom with tetrodotoxin is further evidence that venom depolarizes intramural nerves and liberates transmitters that cause chloride secretion. The identity of the other transmitters is not known.

Stereospecific inhibition by ozolinone of stimulated chloride secretion in rabbit colon descendens

1982 ◽  
Vol 318 (4) ◽  
pp. 363-367 ◽  
Author(s):  
Konrad Heintze ◽  
Karl-Uwe Petersen ◽  
Otto Heidenreich
Keyword(s):  
Chloride Secretion ◽  
Rabbit Colon

Localization of Sodium in Normal and Inhibited Transporting Epithelia

1971 ◽  
Vol 29 ◽  
pp. 392-393
Author(s):  
G. I. Kaye ◽  
J. D. Cole
Keyword(s):  
Plasma Membrane ◽  
Similar Pattern ◽  
Fixation Method ◽  
Colonic Epithelium ◽  
Gallbladder Epithelium ◽  
Rabbit Colon ◽  
Rabbit Gallbladder

For a number of years we have used an adaptation of Komnick's KSb(OH)6-OsO4 fixation method for the localization of sodium in tissues in order to study transporting epithelia under a number of different conditions. We have shown that in actively transporting rabbit gallbladder epithelium, large quantities of NaSb(OH)6 precipitate are found in the distended intercellular compartment, while localization of precipitate is confined to the inner side of the lateral plasma membrane in inactive gallbladder epithelium. A similar pattern of distribution of precipitate has been demonstrated in human and rabbit colon in active and inactive states and in the inactive colonic epithelium of hibernating frogs.

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