Wolffian duct and epididymal agenesis fails to prevent testicular descent

1990 ◽  
Vol 5 (6) ◽  
Author(s):  
Gordon Baikie ◽  
JohnM. Hutson
Keyword(s):  
Wolffian Duct ◽  
Testicular Descent

Exogenous androgens reduce the expression of INSL3, a hormone involved in normal testicular descent, in fetal Leydig cells

2014 ◽  
Author(s):  
W Colin Duncan ◽  
Fiona Connolly ◽  
Lyndsey Boswell ◽  
Graeme Burt ◽  
Alan S McNeilly ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Testicular Descent ◽  
Fetal Leydig Cells

The Gubernaculum and the Evolution of Testicular Descent

HAPS Educator ◽  
2017 ◽  
Vol 21 (3) ◽  
pp. 12-19 ◽  
Author(s):  
David M. Darda
Keyword(s):  
Testicular Descent

Epididymal Cyst - A Case Study

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Vinayak A. Mali ◽  
Dr.Prashanth K.
Keyword(s):  
Local Anaesthesia ◽  
Marked Improvement ◽  
Wolffian Duct ◽  
Cystic Degeneration ◽  
Mullerian Duct ◽  
Duct System ◽  
Middle Aged ◽  
Müllerian Duct ◽  
Mesonephric Duct

Cysts of the epididymis are usually congenital and derived from an embryonic remnant. These cysts are due to cystic degeneration of remnants of the paramesonephric or Mullerian duct and Remnants of the mesonephric duct or Wolffian duct system. Here we report a case of bilateral Epididymal cysts in a middle aged man with a complaint of scrotal lump and infertility since 15 years. He was treated with excision of the cysts under local anaesthesia and had a marked improvement in scrotal discomfort and urgency of micturition after the treatment.

scholarly journals INSL3/LGR8 role in testicular descent and cryptorchidism

2005 ◽  
Vol 10 (1) ◽  
pp. 49-54 ◽  
Author(s):  
NV Bogatcheva ◽  
AI Agoulnik
Keyword(s):  
Testicular Descent

Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniel A. Landero-Huerta ◽  
Rosa M. Vigueras-Villaseñor ◽  
Lucía Taja-Chayeb ◽  
Fabiola García-Andrade ◽  
Elena Aréchaga-Ocampo ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Receptor Gene ◽  
Germ Cell Tumors ◽  
Androgen Receptor Gene ◽  
Testicular Descent ◽  
Healthy Individuals ◽  
Testicular Germ Cell ◽  
Molecular Alteration ◽  
Mexican Patients

Abstract Objectives Cryptorchidism is the most common genitourinary birth defect in live newborn males and is considered as an important risk factor for testicular germ cell tumors and infertility. The Androgen Receptor gene is important in this pathology due to its participation, mainly, in the inguinoscrotal phase of testicular descent. We determine the length of the CAG tract in the Androgen Receptor (AR) gene in Mexican patients with nonsyndromic cryptorchidism. Methods One hundred and 15 males were included; of these, 62 had nonsyndromic cryptorchidism and 53 were healthy volunteers. DNA was extracted from a peripheral blood samples, subsequently, the CAG tract in exon 1 of AR gene was amplified by PCR and sequenced. Results Mexican patients with nonsyndromic cryptorchidism presented 25.03 ± 2.58 repeats of CAG tract in the AR gene compared to 22.72 ± 3.17 repeats of CAG tract in Mexican healthy individuals (p≤0.0001; t value of 4.3). Furthermore, the deletion of codon 57 that corresponds to the deletion of a leucine residue at position 57 (Del L57) in the AR gene was found for the first time in a nonsyndromic cryptorchidism patient. This molecular alteration has been related previously to testicular germ cell tumor (TGCT). Conclusions The CAG tract in the AR gene is longer in patients with nonsyndromic cryptorchidism than in healthy individuals, supporting the association between this polymorphism of the AR gene and nonsyndromic cryptorchidism in the Mexican population.

Association of antimullerian hormone with the size of the appendix testis, the androgen and estrogen receptors and their expression in the appendix testis, in congenital cryptorchidism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Xenophon Sinopidis ◽  
Eirini Kostopoulou ◽  
Andrea Paola Rojas-Gil ◽  
Antonios Panagidis ◽  
Eleni Kourea ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Receptor Expression ◽  
Testicular Descent ◽  
Antimullerian Hormone ◽  
Mullerian Ducts ◽  
Score Method ◽  
Antimüllerian Hormone ◽  
Unilateral Cryptorchidism ◽  
Appendix Testis

Abstract Objectives Antimullerian hormone (AMH) causes regression of the mullerian ducts in the male fetus. The appendix testis (AT) is a vestigial remnant of mullerian duct origin, containing both androgen (AR) and estrogen (ER) receptors. The role of both AMH and AT in testicular descent is yet to be studied. We investigated the possible association of AMH with AT size, the AR and ER, and their expression in the AT, in congenital cryptorchidism. Methods A total of 26 patients with congenital unilateral cryptorchidism and 26 controls with orthotopic testes were investigated, and 21 ATs were identified in each group. AMH and insulin-like three hormone (INSL3) concentrations were measured with spectrophotometry. AR and ER receptor expression was assessed with immunohistochemistry using monoclonal antibodies R441 for AR and MAB463 for ER. For the estimation of receptor expression, the Allred Score method was used. Results AMH concentrations did not present significant differences between patients with congenital cryptorchidism and the controls. Also, no correlation was found between AMH, INSL3, and AT length. Allred scores did not present significant differences. However, expression percentiles and intensity for both receptors presented significant differences. Three children with cryptorchidism and the highest AMH levels also had the highest estrogen receptor scores in the AT. Conclusions No association was found between AMH and the studied major parameters. However, higher AMH concentrations, in combination with higher estrogen receptor scores in the AT, may play a role in cryptorchidism in some children. Larger population samples are needed to verify this observation.

Normative Values for Testicular Descent from Infancy to Adulthood

1993 ◽  
Vol 39 (3-4) ◽  
pp. 118-121 ◽  
Author(s):  
J. Sack ◽  
B. Reichman ◽  
A. Fix
Keyword(s):  
Normative Values ◽  
Testicular Descent

Paravaginal Wolffian Duct (Mesonephros) Adenocarcinoma: A Light and Electron Microscopic Study

1983 ◽  
Vol 80 (4) ◽  
pp. 539-544 ◽  
Author(s):  
William W. Hinchey ◽  
Elvio G. Silva ◽  
Luis A. Guarda ◽  
Nelson G. Ordonez ◽  
J. Taylor Wharton
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Wolffian Duct ◽  
Electron Microscopic
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