AF-DX 116 differentiates between prejunctional muscarine receptors located on noradrenergic and cholinergic nerves

Author(s):  
F. Dammann ◽  
H. Fuder ◽  
A. Giachetti ◽  
E. Giraldo ◽  
E. Kilbinger ◽  
...  
1973 ◽  
Vol 138 (3) ◽  
pp. 407-420 ◽  
Author(s):  
Per Alm ◽  
Gunnar D. Bloom ◽  
Bengt Carls��

1996 ◽  
Vol 106 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Xiang-Yang Zhang ◽  
Feng-Xia Zhu ◽  
N.Edward Robinson
Keyword(s):  

2002 ◽  
Vol 282 (6) ◽  
pp. L1229-L1238 ◽  
Author(s):  
Paul J. Kingham ◽  
W. Graham McLean ◽  
Deborah A. Sawatzky ◽  
Marie Therese Walsh ◽  
Richard W. Costello

Eosinophils adhere to airway cholinergic nerves and influence nerve cell function by releasing granule proteins onto inhibitory neuronal M2 muscarinic receptors. This study investigated the mechanism of eosinophil degranulation by cholinergic nerves. Eosinophils were cocultured with IMR32 cholinergic nerve cells, and eosinophil peroxidase (EPO) or leukotriene C4 (LTC4) release was measured. Coculture of eosinophils with nerves significantly increased EPO and LTC4 release compared with eosinophils alone. IMR32 cells, like parasympathetic nerves, express the adhesion molecules vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 (ICAM-1). Inhibition of these adhesion molecules alone or in combination significantly inhibited eosinophil degranulation. IMR32 cells also significantly augmented the eosinophil degranulation produced by formyl-Met-Leu-Phe. Eosinophil adhesion to IMR32 cells resulted in an ICAM-1-mediated production of reactive oxygen species via a neuronal NADPH oxidase, inhibition of which significantly inhibited eosinophil degranulation. Additionally, eosinophil adhesion increased the release of ACh from IMR32 cells. These neuroinflammatory cell interactions may be relevant in a variety of inflammatory and neurological conditions.


1993 ◽  
Vol 110 (4) ◽  
pp. 1329-1334 ◽  
Author(s):  
Guy E. Boeckxstaens ◽  
Joris G. Man ◽  
Paul A. Pelckmans ◽  
Kristel M. Cromheeke ◽  
Arnold G. Herman ◽  
...  

Endocrinology ◽  
1979 ◽  
Vol 105 (1) ◽  
pp. 7-9 ◽  
Author(s):  
A. MELANDER ◽  
F. SUNDLER

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