No evidence for presynaptic opioid receptors on cholinergic, but presence of ?-receptors on dopaminergic neurons in the rabbit caudate nucleus: involvement of endogeneous opioids

1993 ◽  
Vol 348 (3) ◽  
Author(s):  
R. Jackisch ◽  
H. Hotz ◽  
G. Hertting
Keyword(s):  
Caudate Nucleus ◽  
Opioid Receptors ◽  
Dopaminergic Neurons ◽  
Rabbit Caudate Nucleus

Intrastriatal implantation of interleukin-1

1994 ◽  
Vol 80 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Jin Wang ◽  
Krzysztof S. Bankiewicz ◽  
Robert J. Plunkett ◽  
Edward H. Oldfield
Keyword(s):  
Substantia Nigra ◽  
Caudate Nucleus ◽  
Ventral Tegmental Area ◽  
Dopaminergic Neurons ◽  
Interleukin 1 ◽  
Behavioral Recovery ◽  
Content Type ◽  
Median Forebrain Bundle ◽  
Ventral Tegmental ◽  
Fine Print

✓ Intrastriatal implantation with dopaminergic or nondopaminergic tissue can elicit behavioral recovery in parkinsonian animals. Because in these animals, especially in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned monkeys, there are still considerable numbers of dopaminergic neurons left in the mesencephalon, implantation-induced trophic effects on host residual dopaminergic neurons have been suggested as a mechanism underlying the behavioral recovery. Gliosis around the graft is a universal finding in any implantation procedure and is probably mediated by interleukin-1 (IL-1); in addition, activated astrocytes secrete several neurotrophic factors in vitro. Therefore, the authors postulated that trophic effects from IL-1-induced gliosis may be a “final common pathway” for recovery in parkinsonian animals after implantation. Hemiparkinsonism was induced in rats by injection of 6-hydroxydopamine either directly into the substantia nigra or into the median forebrain bundle. The substantia nigra-lesioned rats showed complete depletion of dopaminergic neurons in the substantia nigra but sparing of those in the ventral tegmental area, whereas the median forebrain bundle-lesioned animals had depletion of dopaminergic cells in the substantia nigra and the ventral tegmental area. Polymer pellets containing either slow-released IL-1 alpha and beta or placebo pellets were implanted in the caudate nucleus on the lesioned side in both groups. The rats' rotational response to amphetamine was tested weekly for 8 weeks. Selective substantia nigra-lesioned rats with implantation of IL-1 pellets had a 45% reduction in amphetamine-induced rotation, whereas placebo-implanted substantia nigra-lesioned rats had a 14% reduction in rotation. In the median forebrain bundle-lesioned group, neither IL-1 nor placebo implantation elicited any effect on turning. Immunohistochemical staining for glial fibrillary acidic protein was markedly increased surrounding the IL-1 pellets compared to the placebo pellets. In the selective substantia nigra-lesioned rats with IL-1 pellets implanted in the caudate nucleus, a considerable number of tyrosine hydroxylase immunoreactive (TH-IR) fibers were observed in the medial and middle portions of the caudate nucleus. Fewer TH-IR fibers were seen in the rats with placebo-bearing pellets. These results suggest that neurotrophic activities mediated by IL-1 and reactive astrocytes might be a common path through which tissue trauma and some tissue transplants exert their beneficial effects in parkinsonian animals. Furthermore, most of the sprouted dopaminergic fibers induced by IL-1 in the caudate nucleus come from dopaminergic neurons in the ventral tegmental area.

Pathways of dopamine metabolism in the rabbit caudate nucleus in vitro

1981 ◽  
Vol 316 (3) ◽  
pp. 205-217 ◽  
Author(s):  
Anton Zumstein ◽  
Winfried Karduck ◽  
Klaus Starke
Keyword(s):  
Caudate Nucleus ◽  
Dopamine Metabolism ◽  
Rabbit Caudate Nucleus
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