Growth inhibitory effect of recombinant ? and ? interferon on human glioma cells

1987 ◽  
Vol 5 (4) ◽  
pp. 323-330 ◽  
Author(s):  
W. K. Alfred Yung ◽  
Peter A. Steck ◽  
Peter J. Kelleher ◽  
Richard P. Moser ◽  
Michael G. Rosenblum
Keyword(s):  
Glioma Cells ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory

scholarly journals Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells

2015 ◽  
Vol 10 (4) ◽  
pp. 966
Author(s):  
Ji-Heng Hao ◽  
Dian-Feng Hu ◽  
Li-Mei Mao ◽  
Shi-Gang Zhang ◽  
Ji-Yue Wang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Glioma Cells ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Expression Of Genes ◽  
Acid Conjugate ◽  
G0 Phase ◽  
Induced Apoptosis ◽  
Endothelial Growth Factor

<p class="Abstract">The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>

scholarly journals Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells

2021 ◽  
Author(s):  
Te-Yu Hung ◽  
Huai-Ying Ingrid Huang ◽  
Sheng-Nan Wu ◽  
Chin-Wei Huang
Keyword(s):  
Antiepileptic Drug ◽  
Glioma Cells ◽  
Ionic Currents ◽  
Ionic Channels ◽  
Underlying Mechanism ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Calcium Activated Potassium Channels ◽  
Inwardly Rectifying

Abstract Background: Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely unclear. Methods: With the aid of patch-clamp technology, we investigated the effects of VGB on various ionic currents in the glioblastoma multiforme cell line 13-06-MG. Results: In cell-attached configuration, VGB concentration-dependently reduced the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels, while DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) counteracted the VGB-induced inhibition of IKCa channels. However, the activity of neither large-conductance Ca2+-activated (BKCa) nor inwardly rectifying K+ (KIR) channels were affected by the presence of VGB in human 13-06-MG cells. However, in the continued presence of VGB, the addition of GAL-021 or BaCl2 effectively suppressed BKCa and KIR channels. Conclusions: The inhibitory effect of VGB on IKCa channels demonstrated in the current study could be an important underlying mechanism of VGB-induced antineoplastic (e.g., anti-glioma) actions.

Isolation and Expression of Rat Interferon β Gene and Growth-Inhibitory Effect of Its Expression on Rat Glioma Cells

1997 ◽  
Vol 232 (3) ◽  
pp. 698-701 ◽  
Author(s):  
Shin-ichiro Yokoyama ◽  
Nobuko Ohishi ◽  
Masayo Shamoto ◽  
Yoshihiko Watanabe ◽  
Kunio Yagi
Keyword(s):  
Glioma Cells ◽  
Inhibitory Effect ◽  
Interferon Β ◽  
Growth Inhibitory Effect ◽  
Rat Glioma ◽  
Growth Inhibitory

Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp)4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo

2014 ◽  
Vol 19 (6) ◽  
pp. 1025-1035 ◽  
Author(s):  
Marcel Benadiba ◽  
Iguatinã de M. Costa ◽  
Rodrigo L. S. R. Santos ◽  
Fernanda Oliveira Serachi ◽  
Denise de Oliveira Silva ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Inhibitory Effects ◽  
Human Glioma Cells ◽  
Growth Inhibitory ◽  
Orthotopic Glioma

scholarly journals Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells

2020 ◽  
Author(s):  
Te-Yu Hung ◽  
Huai-Ying Ingrid Huang ◽  
Sheng-Nan Wu ◽  
Chin-Wei Huang
Keyword(s):  
Antiepileptic Drug ◽  
Glioma Cells ◽  
Ionic Currents ◽  
Ionic Channels ◽  
Underlying Mechanism ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Calcium Activated Potassium Channels ◽  
Inwardly Rectifying

Abstract Background: Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely unclear. Methods: With the aid of patch-clamp technology, we investigated the effects of VGB on various ionic currents in the glioblastoma multiforme cell line 13-06-MG. Results: In cell-attached configuration, VGB concentration-dependently reduced the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels, while DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) counteracted the VGB-induced inhibition of IKCa channels. However, the activity of neither large-conductance Ca2+-activated (BKCa) nor inwardly rectifying K+ (KIR) channels were affected by the presence of VGB in human 13-06-MG cells. However, in the continued presence of VGB, the addition of GAL-021 or BaCl2 effectively suppressed BKCa and KIR channels. Conclusions: The inhibitory effect of VGB on IKCa channels demonstrated in the current study could be an important underlying mechanism of VGB-induced antineoplastic (e.g., anti-glioma) actions.

scholarly journals Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Te-Yu Hung ◽  
Huai-Ying Ingrid Huang ◽  
Sheng-Nan Wu ◽  
Chin-Wei Huang
Keyword(s):  
Antiepileptic Drug ◽  
Glioma Cells ◽  
Ionic Currents ◽  
Ionic Channels ◽  
Underlying Mechanism ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Calcium Activated Potassium Channels ◽  
Inwardly Rectifying

Abstract Background Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely unclear. Methods With the aid of patch-clamp technology, we investigated the effects of VGB on various ionic currents in the glioblastoma multiforme cell line 13–06-MG. Results In cell-attached configuration, VGB concentration-dependently reduced the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels, while DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) counteracted the VGB-induced inhibition of IKCa channels. However, the activity of neither large-conductance Ca2+-activated (BKCa) nor inwardly rectifying K+ (KIR) channels were affected by the presence of VGB in human 13–06-MG cells. However, in the continued presence of VGB, the addition of GAL-021 or BaCl2 effectively suppressed BKCa and KIR channels. Conclusions The inhibitory effect of VGB on IKCa channels demonstrated in the current study could be an important underlying mechanism of VGB-induced antineoplastic (e.g., anti-glioma) actions.

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