Isolation and Expression of Rat Interferon β Gene and Growth-Inhibitory Effect of Its Expression on Rat Glioma Cells

1997 ◽  
Vol 232 (3) ◽  
pp. 698-701 ◽  
Author(s):  
Shin-ichiro Yokoyama ◽  
Nobuko Ohishi ◽  
Masayo Shamoto ◽  
Yoshihiko Watanabe ◽  
Kunio Yagi
Keyword(s):  
Glioma Cells ◽  
Inhibitory Effect ◽  
Interferon Β ◽  
Growth Inhibitory Effect ◽  
Rat Glioma ◽  
Growth Inhibitory

Growth-inhibitory effect of prostaglandin D2 on mouse glioma cells

1984 ◽  
Vol 61 (5) ◽  
pp. 912-917 ◽  
Author(s):  
Atsushi Keyaki ◽  
Hajime Handa ◽  
Junkoh Yamashita ◽  
Yasuhiko Tokuriki ◽  
Shin-Ichi Otsuka ◽  
...  
Keyword(s):  
Intraperitoneal Injection ◽  
Glioma Cells ◽  
Inhibitory Effect ◽  
Prostaglandin D2 ◽  
Growth Inhibitory Effect ◽  
Content Type ◽  
Growth Inhibitory ◽  
Mouse Glioma

✓ The effects of prostaglandin D2 (PGD2) on the growth of mouse malignant glioma cells were studied in vitro and in vivo. The in vitro studies consisted of various concentrations of prostaglandins (PG's) being added to cultures of mouse glioma cells. At concentrations above 2.5 µg/ml, PGD2 strongly inhibited the proliferation of glioma cells, whereas PGE2 had no effect at the same value. Exposure to 5.0 µg/ml PGD2 for more than 2 hours resulted in inhibition of glioma cell proliferation. This growth-inhibitory effect of PGD2 was related to the inhibition of DNA synthesis of the cells. The in vivo studies were performed with a subcutaneously transplanted mouse glioma model. Injection of 0.5 mg/kg PGD2 into the tumor was more effective than the same concentration given by intraperitoneal injection. In mice with intracranially transplanted glioma, daily intraperitoneal injection of 0.5 mg/kg PGD2 had no significant effect on survival time.

Growth inhibitory effect of recombinant ? and ? interferon on human glioma cells

1987 ◽  
Vol 5 (4) ◽  
pp. 323-330 ◽  
Author(s):  
W. K. Alfred Yung ◽  
Peter A. Steck ◽  
Peter J. Kelleher ◽  
Richard P. Moser ◽  
Michael G. Rosenblum
Keyword(s):  
Glioma Cells ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory

Reduction of linoleic acid inhibition in production of conjugated linoleic acid byPropionibacterium freudenreichiissp.shermanii

2001 ◽  
Vol 47 (8) ◽  
pp. 735-740 ◽  
Author(s):  
A Rainio ◽  
M Vahvaselkä ◽  
T Suomalainen ◽  
S Laakso
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Inhibitory Effect ◽  
Propionibacterium Freudenreichii ◽  
Growth Inhibitory Effect ◽  
Sorbitan Monooleate ◽  
Whey Permeate ◽  
Growth Inhibitory ◽  
De Man ◽  
Sufficient Concentration

A method for the production of conjugated linoleic acid (CLA) from linoleic acid (LA) using growing cultures of Propionibacterium freudenreichii ssp. shermanii JS was developed. The growth inhibitory effect of LA was eliminated by dispersing it in a sufficient concentration of polyoxyethylene sorbitan monooleate detergent. For the whey permeate medium used, the optimum LA:detergent ratio was 1:15 (w/w). As a result, the cultures tolerated at least 1000 µg·mL–1LA, which was converted to CLA with 57%–87% efficiency. The cis-9, trans-11 and trans-9, cis-11 isomers constituted 85%–90% of the CLA produced. The feasibility of the method was demonstrated also in de Man – Rogosa–Sharpe (MRS) broth.Key words: conjugated linoleic acid, linoleic acid, Propionibacterium freudenreichii ssp. shermanii.

Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids

1990 ◽  
Vol 75 (4) ◽  
pp. 489-495 ◽  
Author(s):  
L. M. Larocca ◽  
M. Piantelli ◽  
G. Leone ◽  
S. Sica ◽  
L. Teofili ◽  
...  
Keyword(s):  
Binding Sites ◽  
Inhibitory Effect ◽  
Type Ii ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory
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