The role of diet and drugs in lowering serum cholesterol in the postmyocardial infarction patient

1989 ◽  
Vol 2 (6) ◽  
pp. 795-799
Author(s):  
G. Schettler
Keyword(s):  
Serum Cholesterol ◽  
Postmyocardial Infarction

scholarly journals Effect of Acute Mental Stress on Heart Rate and QT Variability in Postmyocardial Infarction Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Damiano Magrì ◽  
Gianfranco Piccirillo ◽  
Raffaele Quaglione ◽  
Annalaura Dell’Armi ◽  
Marilena Mitra ◽  
...  
Keyword(s):  
Acute Stress ◽  
Management Strategies ◽  
Low Frequency ◽  
Frequency Component ◽  
Postmyocardial Infarction ◽  
Increased Risk ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Emotionally charged events are associated with an increased risk of sudden cardiac death (SCD). In this study we assessed RR and QT variability index (QTVI) at baseline during anger recall test (AR). We calculated QTVI from a 5-min ECG recording and from a 10-beats segment around the presumed maximum sympathetic activation in thirty post-myocardial infarction patients under β-blocker therapy and 10 controls underwent. In all groups, the low-frequency component of RR and SBP increased during AR. In all recordings, the QTVI calculated on a 5-min ECG recording and the were higher in patients than in controls (P < 0.05). The QTVI during AR remained unchanged from baseline within each group. Conversely, during AR, the in controls diminished significantly (P < 0.05) from baseline whereas in patients remained unchanged. The inability to buffer an acute stress-induced increase in sympathetic activity could explain why events charged with acute stress are associated with an increased risk of ventricular arrhythmias in this setting of patients and support the role of cognitive behavior stress management strategies.

Lp(a) lipoprotein concentration in serum of patients with heavy proteinuria of different origin.

1989 ◽  
Vol 35 (10) ◽  
pp. 2121-2123 ◽  
Author(s):  
I Karádi ◽  
L Romics ◽  
G Pálos ◽  
J Domán ◽  
I Kaszás ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Membranoproliferative Glomerulonephritis ◽  
Renal Tissue ◽  
Urinary Protein ◽  
Primary Amyloidosis ◽  
Protein Loss ◽  
Heavy Proteinuria ◽  
Lipoprotein Concentration ◽  
Different Origin

Abstract We measured serum cholesterol, triglyceride, and lipoprotein Lp(a) concentrations in serum of 37 patients with massive proteinuria of different origin, comparing values with those for age- and sex-matched controls and finding significantly increased Lp(a) concentration in the total group of patients compared with controls. Lp(a) concentration was not correlated with serum cholesterol, triglyceride, serum creatinine, daily urinary protein loss, or selectivity index. Selecting the patients according to their histological diagnosis obtained by renal needle biopsy, we found divergent results in seven patients with minimal change disease (MCD) compared with 11 patients with membranoproliferative glomerulonephritis. Lp(a) in MCD patients did not differ from that controls (101 +/- 102 and 90 +/- 115 mg/L) and correlated positively with total daily urinary protein loss (r = 0.7962, P less than 0.05). In contrast, the patients with membranoproliferative glomerulonephritis had significantly higher Lp(a) values than the controls (219 +/- 222 mg/L), and Lp(a) concentrations correlated negatively with the daily protein loss in urine (r = -0.6545, P less than 0.05). The most surprising results were the marked Lp(a) concentrations in serum of three patients with primary amyloidosis and nephrosis syndrome. Our results indicate a regulatory role of the kidney in the metabolism of Lp(a) and different effects on the serum Lp(a) concentration, depending on the type of damage to renal tissue.

scholarly journals The Role of Echocardiography in the Assessment of Ventricular Septal Rupture Postmyocardial Infarction

2017 ◽  
Vol 33 (4) ◽  
pp. 291-294 ◽  
Author(s):  
Michael Rampoldi ◽  
Eric Kallstrom
Keyword(s):  
Myocardial Infarction ◽  
Surgical Intervention ◽  
Rapid Assessment ◽  
Mechanical Complication ◽  
Ventricular Septal Rupture ◽  
Anterior Myocardial Infarction ◽  
Postmyocardial Infarction ◽  
Life Threatening

Ventricular septal rupture (VSR) is a rare life-threatening mechanical complication secondary to acute myocardial infarction that usually occurs 2 to 8 days after infarction and frequently precipitates cardiogenic shock. The mortality rate for VSR has been reported to be between 41% and 80%; therefore, immediate surgical intervention should be considered. Furthermore, VSR is a complication of 0.17% to 0.31% of patients who present with an anterior myocardial infarction. Because of the rarity of this pathology, the role of transthoracic echocardiographic investigation will help to improve what is already considered a poor prognosis for these types of patients. This case study illustrates how transthoracic echocardiography plays an essential role in the rapid assessment and diagnosis of VSR in clinical practice.

scholarly journals β-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis

2017 ◽  
Vol 313 (2) ◽  
pp. H338-H353 ◽  
Author(s):  
Jakub Tomek ◽  
Blanca Rodriguez ◽  
Gil Bub ◽  
Jordi Heijman
Keyword(s):  
Adrenergic Receptor ◽  
Border Zone ◽  
Adrenergic Stimulation ◽  
Cell Coupling ◽  
Postmyocardial Infarction ◽  
Model Cell ◽  
Cycle Lengths ◽  
Underlying Mechanisms ◽  
First Time

The border zone (BZ) of the viable myocardium adjacent to an infarct undergoes extensive autonomic and electrical remodeling and is prone to repolarization alternans-induced cardiac arrhythmias. BZ remodeling processes may promote or inhibit Ca2+ and/or repolarization alternans and may differentially affect ventricular arrhythmogenesis. Here, we used a detailed computational model of the canine ventricular cardiomyocyte to study the determinants of alternans in the BZ and their regulation by β-adrenergic receptor (β-AR) stimulation. The BZ model developed Ca2+ transient alternans at slower pacing cycle lengths than the control model, suggesting that the BZ may promote spatially heterogeneous alternans formation in an infarcted heart. β-AR stimulation abolished alternans. By evaluating all combinations of downstream β-AR stimulation targets, we identified both direct (via ryanodine receptor channels) and indirect [via sarcoplasmic reticulum (SR) Ca2+ load] modulation of SR Ca2+ release as critical determinants of Ca2+ transient alternans. These findings were confirmed in a human ventricular cardiomyocyte model. Cell-to-cell coupling indirectly modulated the likelihood of alternans by affecting the action potential upstroke, reducing the trigger for SR Ca2+ release in one-dimensional strand simulations. However, β-AR stimulation inhibited alternans in both single and multicellular simulations. Taken together, these data highlight a potential antiarrhythmic role of sympathetic hyperinnervation in the BZ by reducing the likelihood of alternans and provide new insights into the underlying mechanisms controlling Ca2+ transient and repolarization alternans. NEW & NOTEWORTHY We integrated, for the first time, postmyocardial infarction electrical and autonomic remodeling in a detailed, validated computer model of β-adrenergic stimulation in ventricular cardiomyocytes. Here, we show that β-adrenergic stimulation inhibits alternans and provide novel insights into underlying mechanisms, adding to a recent controversy about pro-/antiarrhythmic effects of postmyocardial infarction hyperinnervation. Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/%CE%B2-ar-stimulation-and-alternans-in-border-zone-cardiomyocytes/ .

scholarly journals Role of Berberis lycium in Reducing Serum Cholesterol in Broilers

2007 ◽  
Vol 20 (4) ◽  
pp. 563-568 ◽  
Author(s):  
N. Chand ◽  
F. R. Durrani ◽  
M. S. Qureshi ◽  
Z. Durrani
Keyword(s):  
Serum Cholesterol ◽  
Berberis Lycium

Prophylactic Potential of Conventional and Supercritical Garlic Extracts to Alleviate Diet Related Malfunctions

2019 ◽  
Vol 10 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Kanza A. Awan ◽  
Masood S. Butt ◽  
Faiza Ashfaq ◽  
Hussan Munir ◽  
Hafiz A.R. Suleria
Keyword(s):  
Weight Gain ◽  
Glucose Level ◽  
Serum Cholesterol ◽  
Therapeutic Interventions ◽  
Sprague Dawley ◽  
Maximum Increase ◽  
Antidiabetic Agents ◽  
Sprague Dawley Rats ◽  
Maximum Decrease

Objectives: The present research was tailored to explore the prophylactic role of garlic extracts to mitigate some diet related malfunctions. The recent patents regarding antidiabetic agents (US 20140147528 A1) and garlic compositions (US 20110129580 A1) also helped in the study design. </P><P> Methods: Bioevaluation trials were conducted on Sprague Dawley rats by feeding garlic extracts for a period of sixty days. Accordingly, three studies were carried out comprising of normal, hyperglycemic and hypercholesterolemic rats. Drink & feed intakes and weight gain were measured throughout the trial. After sixty days, collected sera from rats were analyzed for serum cholesterol, LDL, HDL & triglyceride levels and glucose & insulin concentrations. Finally, the data obtained were subjected to statistical modeling. </P><P> Results: Results concerning the bioevaluation trials revealed that maximum 12.39% reduction was observed in serum cholesterol in Study III (hypercholesterolemic rats) on the provision of garlic supercritical extract (nutraceutical diet) followed by 10.24% decline in rats fed on solvent extract supplemented diet (functional diet). Regarding LDL, maximum decrease (17.02%) was recorded on the administration of diet having garlic supercritical extract to the hypercholesterolemic rats. While in Study II (hyperglycemic rats) maximum decrease of 11.03% in glucose level was recorded in rats fed on supercritical extract containing diet. In the same group maximum increase in insulin (7.95%) was recorded. </P><P> Conclusions: From the current investigations, it can be concluded that garlic based designer foods possess the prophylactic perspectives to alleviate the risk of metabolic ailments. Thus, it can be used in the diet based therapeutic interventions as an adjuvant to pharmaceuticals.

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