Population biology of avena. VI. The role of genetic polymorphisms in the outcome of interspecific competition

Genetica ◽  
1978 ◽  
Vol 48 (2) ◽  
pp. 151-159 ◽  
Author(s):  
B. Yazdi-Samadi ◽  
K. K. Wu ◽  
S. K. Jain
Keyword(s):  
Interspecific Competition ◽  
Genetic Polymorphisms ◽  
Population Biology

Role of the Genetic Polymorphisms in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene

2007 ◽  
Vol 31 (s1) ◽  
pp. S36-S42 ◽  
Author(s):  
Takayuki Uchimoto ◽  
Sakae Itoga ◽  
Masahiko Nezu ◽  
Masahiko Sunaga ◽  
Takeshi Tomonaga ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Genetic Polymorphisms ◽  
Cyp2e1 Gene ◽  
Flanking Region

The Role of Genetic Polymorphisms in Oxidative Stress

2014 ◽  
pp. 7-41
Author(s):  
Ana Kallaur ◽  
Sayonara Oliveira ◽  
Edna Vissoci Reiche
Keyword(s):  
Oxidative Stress ◽  
Genetic Polymorphisms

scholarly journals Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis

2021 ◽  
Vol 15 (5) ◽  
Author(s):  
Azza Elamir ◽  
Soha Senara ◽  
Noha Abdelghaffar ◽  
Sylvana Gaber ◽  
Hassan El Sayed
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Polymorphisms ◽  
Diagnostic Role ◽  
Lncrna Gas5

scholarly journals ROLE OF GABAERGIC SYSTEM GENETIC POLYMORPHISMS IN THE DEVELOPMENT OF OBSTRUCTIVE SLEEP APNEA SYNDROME IN ASTHMA PATIENTS

2019 ◽  
Vol 1 (71) ◽  
pp. 37-44
Author(s):  
Елизавета Шелудько ◽  
Elizaveta Shelud'ko ◽  
Денис Наумов ◽  
Denis Naumov ◽  
Дина Гассан ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Genetic Polymorphisms ◽  
Sleep Apnea Syndrome ◽  
Gabaergic System ◽  
Obstructive Sleep ◽  
Asthma Patients ◽  
Apnea Syndrome

The results of recent studies indicate the potential role of gamma-aminobutyric acid (GABA), as an inhibitory mediator of the central nervous system, in the pathogenesis of obstructive sleep apnea syndrome (OSAS) ‒ a common disorder that often accompanies asthma. The aim of the study was to investigate the possible role of some GABAergic system genetic polymorphisms in the formation of OSAS in asthma patients. Overnight cardiorespiratory monitoring was performed to diagnose OSAS and spirometry was conducted to evaluate the airway reactivity to the bronchodilator fenoterol in 184 asthma patients. Polymorphisms of GAD1, GAD2, GABBR1 and GABBR2 genes (15 polymorphisms in total) were genotyped by LATE-PCR method. Significant results were obtained for rs3749034 polymorphism of GAD1 gene and rs35400353 of GABBR2 in association analysis with the presence of OSAS. rs3749034 significantly influenced the presence of OSAS in males, which was accompanied by the predominance of the CC genotype among patients with OSAS, while CT+TT genotypes were more common in patients without OSAS (OR 3.9 95%CI [1.36–11.67], p=0.01). In total sample GAD1 rs3749034 polymorphism was an independent factor increasing the likelihood of having OSAS after adjustment for significant confounders (OR 1.9 95%CI [1.23–3.15], p=0.005). rs35400353 polymorphism was also associated with OSAS after adjustment for confounders, although its relationship was less significant (OR 1.5 95%CI [1.1–2.3], p=0.04). There was a tendency for interrelation with airway hyperresponsiveness to bronchodilator for both polymorphisms: rs3749034 ‒ in case of CT+TT genotypes, rs35400353 ‒ in case of DD genotype. rs3749034 polymorphism also significantly influenced lung function parameters. After additional verification of the results, the identified genetic polymorphisms may be used to individually predict the risk of OSAS as well as for the development of personalized approaches in asthma treatment using GABA.

scholarly journals Variation in PAH-related DNA adduct levels among non-smokers: The role of multiple genetic polymorphisms and nucleotide excision repair phenotype

2012 ◽  
Vol 132 (12) ◽  
pp. 2738-2747 ◽  
Author(s):  
Arash Etemadi ◽  
Farhad Islami ◽  
David H. Phillips ◽  
Roger Godschalk ◽  
Asieh Golozar ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Dna Adduct ◽  
Nucleotide Excision
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