A cytogenetic analysis of meiotic drive in the mosquito, Aedes aegypti (L.)

Genetica ◽  
1976 ◽  
Vol 46 (3) ◽  
pp. 297-318 ◽  
Author(s):  
M. E. Newton ◽  
R. J. Wood ◽  
D. I. Southern
Keyword(s):  
Aedes Aegypti ◽  
Cytogenetic Analysis ◽  
Meiotic Drive

Variation in Y chromosome meiotic drive in Aedes aegypti (Diptera: Culicidae): a potential genetic approach to mosquito control

1997 ◽  
Vol 87 (6) ◽  
pp. 617-623 ◽  
Author(s):  
K. O. Owusu-Daaku ◽  
R. J. Wood ◽  
R. D. Butler
Keyword(s):  
Sex Ratio ◽  
Aedes Aegypti ◽  
Y Chromosome ◽  
Reciprocal Cross ◽  
Mosquito Control ◽  
Meiotic Drive ◽  
Genetic Approach ◽  
Single Form ◽  
Ratio Distortion ◽  
Sex Ratio Distortion

AbstractReciprocal crosses between strains of Aedes aegypti (Linnaeus) from different geographical areas have revealed an unexpectedly complex pattern of holandrically inherited male biased sex ratios in F2. The variation has been interpreted in terms of a web of X–Y interactions in Fl, in which the Y chromosome may or may not show meiotic drive against the X chromosome with which it is paired. The pattern of inheritance is not in agreement with a single form of Y chromosome, driving with different degrees of intensity against Xs of different sensitivity, but indicates different forms of driving Y chromosome. A rule has emerged that if Fl males from any cross give rise to a male distorted sex ratio in their progeny (F2), the males from the reciprocal cross give rise to a normal sex ratio. All eleven newly colonized strains from Ghana showed Y meiotic drive against the Xs of five strains, one of American and four of Australian origin, although one of the eleven showed a greater degree of drive than the other ten against the same sensitive strains. The variation observed is discussed in relation to previous studies on meiotic drive by the MD haplotype, and to the possible exploitation of sex ratio distortion in controlling this potentially dangerous insect.

Meiotic drive at the D(MD) locus and fertility in the mosquito, Aedes aegypti (L.)

Genetica ◽  
1981 ◽  
Vol 54 (3) ◽  
pp. 335-340 ◽  
Author(s):  
J. H. A. M. Youngson ◽  
H. M. Welch ◽  
R. J. Wood
Keyword(s):  
Aedes Aegypti ◽  
Meiotic Drive

Meiotic drive at the D(MD) locus and fertility in the mosquito, Aedes aegypti (L.)

Genetica ◽  
1978 ◽  
Vol 49 (2-3) ◽  
pp. 159-163 ◽  
Author(s):  
R. J. Hastings ◽  
R. J. Wood
Keyword(s):  
Aedes Aegypti ◽  
Meiotic Drive

scholarly journals Genome-Wide Transcriptome Profiling Reveals Genes Associated with Meiotic Drive System of Aedes aegypti

Insects ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 25 ◽  
Author(s):  
Dongyoung Shin ◽  
Susanta Behura ◽  
David Severson
Keyword(s):  
Aedes Aegypti ◽  
Meiotic Drive ◽  
Transcriptome Profiling ◽  
Protein Translation ◽  
Drive System ◽  
Differentially Expressed ◽  
Mosquito Vector ◽  
Whole Genome ◽  
Bioinformatics Analyses ◽  
Whole Genome Microarray

Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive system causes abnormal spermatogenesis that results in highly male-biased progenies from some matings. Although the basic genetics and cytogenetics of the drive mechanism were elucidated, very little is known on a transcriptome level about how the meiotic drive phenotype is expressed in individual males. To address this question, we conducted a whole-genome microarray expression study of testes from a meiotic-drive-carrying strain (T37) in comparison with testes from a non-drive-carrying strain (RED). Based on bioinformatics analyses of the microarray data, we identified 209 genes associated with the meiotic drive phenotype that were significantly differentially expressed between the two strains. K-means cluster analysis revealed nine clusters, in which genes upregulated in T37 testes were assigned to five clusters and genes downregulated in T37 testes were assigned to four clusters. Our data further revealed that genes related to protein translation, phosphorylation, and binding, as well as to G-protein-coupled receptor (GPCR) and peptidase activities, are differentially upregulated in testes from males with the meiotic drive genotype. Based on pathway analysis of these differentially expressed genes, it was observed that the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway may play a role in the meiotic drive system. Overall, this investigation enhances our understanding of whole-genome gene expression associated with the meiotic drive system in Ae. aegypti.

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