Facts and Theories of Induced Organ Regeneration

2005 ◽  
pp. 1-38 ◽  
Author(s):  
Ioannis V. Yannas
Keyword(s):  
Organ Regeneration

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

Roles of Hippo signaling pathway in size control of organ regeneration

2015 ◽  
Vol 57 (4) ◽  
pp. 341-351 ◽  
Author(s):  
Shinichi Hayashi ◽  
Hitoshi Yokoyama ◽  
Koji Tamura
Keyword(s):  
Signaling Pathway ◽  
Size Control ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Organ Regeneration

scholarly journals Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
J.-F. Stoltz ◽  
N. de Isla ◽  
Y. P. Li ◽  
D. Bensoussan ◽  
L. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Regenerative Medicine ◽  
Embryonic Stem ◽  
Clinical Applications ◽  
Cardiac Insufficiency ◽  
Immunomodulatory Activity ◽  
Hematopoietic Stem ◽  
Fetal Stem Cells ◽  
Organ Regeneration

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult or even fetal stem cells provide a more interesting approach for clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue, or Wharton’s Jelly are of potential interest for clinical applications in regenerative medicine because they are easily available without ethical problems for their uses. During the last 10 years, these multipotent cells have generated considerable interest and have particularly been shown to escape to allogeneic immune response and be capable of immunomodulatory activity. These properties may be of a great interest for regenerative medicine. Different clinical applications are under study (cardiac insufficiency, atherosclerosis, stroke, bone and cartilage deterioration, diabetes, urology, liver, ophthalmology, and organ’s reconstruction). This review focuses mainly on tissue and organ regeneration using SC and in particular MSC.

scholarly journals Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration

2021 ◽  
Vol 10 ◽  
pp. 100107
Author(s):  
N. Contessi Negrini ◽  
A. Angelova Volponi ◽  
C.A. Higgins ◽  
P.T. Sharpe ◽  
A.D. Celiz
Keyword(s):  
Tissue Engineering ◽  
Organ Regeneration

scholarly journals Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration

2008 ◽  
Vol 294 (6) ◽  
pp. L1158-L1165 ◽  
Author(s):  
R. D. Nolen-Walston ◽  
C. F. Kim ◽  
M. R. Mazan ◽  
E. P. Ingenito ◽  
A. M. Gruntman ◽  
...  
Keyword(s):  
Alveolar Epithelial Cells ◽  
Substantial Contribution ◽  
Potential Contribution ◽  
Type I ◽  
Alveolar Epithelial ◽  
Cellular Kinetics ◽  
Organ Regeneration ◽  
Alveolar Tissue ◽  
Cell Densities ◽  
Lung Regeneration

Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. Whereas postnatal regeneration of alveolar tissue has been attributed to type II alveolar epithelial cells (AECII), we reasoned that bronchioalveolar stem cells (BASCs) have the potential to contribute substantially to this process. To test this hypothesis, unilateral pneumonectomy (PNX) was performed on adult female C57/BL6 mice to stimulate compensatory lung regrowth. The density of BASCs and AECII, and morphometric and physiological measurements, were recorded on days 1, 3, 7, 14, 28, and 45 after surgery. Vital capacity was restored by day 7 after PNX. BASC numbers increased by day 3, peaked to 220% of controls ( P < 0.05) by day 14, and then returned to baseline after active lung regrowth was complete, whereas AECII cell densities increased to 124% of baseline (N/S). Proliferation studies revealed significant BrdU uptake in BASCs and AECII within the first 7 days after PNX. Quantitative analysis using a systems biology model was used to evaluate the potential contribution of BASCs and AECII. The model demonstrated that BASC proliferation and differentiation contributes between 0 and 25% of compensatory alveolar epithelial (type I and II cell) regrowth, demonstrating that regeneration requires a substantial contribution from AECII. The observed cell kinetic profiles can be reconciled using a dual-compartment (BASC and AECII) proliferation model assuming a linear hierarchy of BASCs, AECII, and AECI cells to achieve lung regrowth.

scholarly journals What is the clinical applicability of regenerative therapies in dentistry?

2017 ◽  
Vol 65 (4) ◽  
pp. 359-367 ◽  
Author(s):  
Giulia Tarquinio DEMARCO ◽  
Laura Borges KIRSCHNICK ◽  
Luis Bayardo WATSON ◽  
Marcus Cristian MUNIZ CONDE ◽  
Flávio Fernando DEMARCO ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Platelet Rich Plasma ◽  
Blood Clot ◽  
Collagen Scaffold ◽  
Bone Tissue Regeneration ◽  
Promising Alternative ◽  
Organ Regeneration ◽  
Regenerative Therapies

ABSTRACT Regenerative therapies have been widely developed in dentistry and it is important to incorporate dentists’ knowledge of these new therapies into the dental clinic routine. This study reviewed the literature on regenerative therapies and clinical applications. Tissue engineering has contributed to changes in the paradigm of restorative health sciences. Its pillars underpin the techniques of tissue and organ regeneration. Despite the majority of studies in this field being in vitro, a range of preclinical studies and methodologies has been formed using these principles and they are already being used on humans. The use of platelet-rich plasma and platelet-rich fibrin in surgery as natural scaffolds for the reestablishment of bone and periodontal tissue are often reported in the literature and clinical trials using this approach have shown promising results. Stem cells from autologous dental pulp have been successfully applied in bone tissue regeneration using natural collagen scaffold in humans. In addition, revascularization of the root canal already appears in the literature as a promising alternative to apexification. The principle behind this therapy is the use of the blood clot as a scaffold and the migration of stem cells of the apical papilla to regenerate the dental pulp organ. Final considerations: Although still in the early stages, regenerative therapies can now be used in dental practice. Knowledge of the principles governing these therapies should be understood by the dentist for use in clinical practice.

scholarly journals Potential Use of Stem Cells for Kidney Regeneration

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Takashi Yokoo ◽  
Kei Matsumoto ◽  
Shinya Yokote
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Cell Biology ◽  
Current Knowledge ◽  
Kidney Regeneration ◽  
Major Step ◽  
Kidney Dialysis ◽  
Organ Regeneration ◽  
Renal Stem Cell

Significant advances have been made in stem cell research over the past decade. A number of nonhematopoietic sources of stem cells (or progenitor cells) have been identified, including endothelial stem cells and neural stem cells. These discoveries have been a major step toward the use of stem cells for potential clinical applications of organ regeneration. Accordingly, kidney regeneration is currently gaining considerable attention to replace kidney dialysis as the ultimate therapeutic strategy for renal failure. However, due to anatomic complications, the kidney is believed to be the hardest organ to regenerate; it is virtually impossible to imagine such a complicated organ being completely rebuilt from pluripotent stem cells by gene or chemical manipulation. Nevertheless, several groups are taking on this big challenge. In this manuscript, current advances in renal stem cell research are reviewed and their usefulness for kidney regeneration discussed. We also reviewed the current knowledge of the emerging field of renal stem cell biology.

scholarly journals Toward Inkjet Additive Manufacturing Directly Onto Human Anatomy

2017 ◽  
Author(s):  
Reed A. Johnson ◽  
John J. O’Neill ◽  
Rodney L. Dockter ◽  
Timothy M. Kowalewski
Keyword(s):  
Degrees Of Freedom ◽  
Cell Structure ◽  
Case Depth ◽  
Human Anatomy ◽  
Wound Treatment ◽  
Burn Wound ◽  
Organ Regeneration ◽  
Potential Applications ◽  
Contact Free ◽  
Three Degrees Of Freedom

Bioprinting technology has been rapidly increasing in popularity in the field of tissue engineering. Potential applications include tissue or organ regeneration, creation of biometric multi-layered skin tissue, and burn wound treatment [1]. Recent work has shown that living cells can be successfully applied using inkjet heads without damaging the cells [2]. Electrostatically driven inkjet systems have the benefit of not generating significant heat and therefore do not damage the cell structure. Inkjets have the additional benefit of depositing small droplets with micrometer resolution and therefore can be used to build up tissue like structures. Previous attempts at tracking and drawing on a hand include either direct contact with the hand [3] or tracking the hand only in two degrees of freedom [4]. In this work we present an approach to track a hand with three degrees of freedom and accurately apply a substance contact free to the hand in a desired pattern using a bioprinting compatible inkjet. The third degree of freedom, in this case depth from the hand surface, provides improved control over the distance between the inkjet head and object, thus increasing deposition accuracy.

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