Dye-Based Organogels: Stimuli-Responsive Soft Materials Based on One-Dimensional Self-Assembling Aromatic Dyes

2005 ◽  
pp. 119-160 ◽  
Author(s):  
Tsutomu Ishi-i ◽  
Seiji Shinkai
Keyword(s):  
Soft Materials ◽  
Stimuli Responsive ◽  
One Dimensional ◽  
Self Assembling

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Self-Assembling, Ultrashort Peptide Gels as Antimicrobial Biomaterials

2020 ◽  
Vol 20 (14) ◽  
pp. 1300-1309 ◽  
Author(s):  
Marina Kurbasic ◽  
Evelina Parisi ◽  
Ana M. Garcia ◽  
Silvia Marchesan
Keyword(s):  
Host Defense ◽  
Ad Hoc ◽  
Soft Materials ◽  
Stimuli Responsive ◽  
Host Defense Peptides ◽  
Amyloid Peptides ◽  
Responsive Systems ◽  
Self Assembling ◽  
Function Relationship ◽  
Antimicrobial Biomaterials

Supramolecular antimicrobial hydrogels based on peptides are attractive soft materials for the treatment of infections, considering their ease of preparation and benign fate in biological settings and in the environment. In particular, stimuli-responsive systems that can be assembled/disassembled ad hoc could offer the opportunity to switch on/off their bioactivity as needed. Besides, the shorter is the peptide, the lower its cost of production. However, a structure-to-function relationship is yet to be defined and reported activities are generally not yet competitive relative to traditional antibiotics. Inspiration for their design can be found in host defense peptides (HDPs), which can self-assemble to exert their function. This article reviews research developments in this emerging area, and it examines features, differences and similarities between antimicrobial and amyloid peptides to open the avenue towards the next generation of supramolecular antimicrobial peptides as innovative therapeutic materials.

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

2019 ◽  
Vol 4 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Ryan T. Shafranek ◽  
Joel D. Leger ◽  
Song Zhang ◽  
Munira Khalil ◽  
Xiaodan Gu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Viscoelastic Properties ◽  
Triblock Copolymer ◽  
Thermal Response ◽  
Stimuli Responsive ◽  
Self Assembling ◽  
Polymeric Hydrogels ◽  
Aba Triblock Copolymer ◽  
Responsive Hydrogels

Directed self-assembly in polymeric hydrogels allows tunability of thermal response and viscoelastic properties.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

A new pathway for the formation of radial nematic droplets within a lipid-laden aqueous-liquid crystal interface

RSC Advances ◽  
2014 ◽  
Vol 4 (36) ◽  
pp. 18889-18893 ◽  
Author(s):  
Sumyra Sidiq ◽  
Dibyendu Das ◽  
Santanu Kumar Pal
Keyword(s):  
Liquid Crystal ◽  
Topological Defects ◽  
Soft Materials ◽  
Stimuli Responsive ◽  
First Time ◽  
Crystal Interface

A new pathway for the formation of liquid crystal (LC) droplets with radial LC ordering is reported for the first time in the presence of surfactants and lipids. Interactions of an enzyme with the topological defects in the LC mediate the response of these droplets and thus provide new designs for stimuli-responsive soft materials.

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