scholarly journals Rapidly Progressive White Matter Involvement in Early Childhood: The Expanding Phenotype of Infantile Onset Pompe?

2017 ◽  
pp. 55-62 ◽  
Author(s):  
A. Broomfield ◽  
J. Fletcher ◽  
P. Hensman ◽  
R. Wright ◽  
H. Prunty ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter

scholarly journals Association between breastfeeding during infancy and white matter microstructure in early childhood

NeuroImage ◽  
2021 ◽  
pp. 118084
Author(s):  
Preeti Kar ◽  
Jess E. Reynolds ◽  
Melody N. Grohs ◽  
Rhonda C. Bell ◽  
Megan Jarman ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
White Matter Microstructure

Pediatric diffusion tensor imaging: Normal database and observation of the white matter maturation in early childhood

NeuroImage ◽  
2006 ◽  
Vol 29 (2) ◽  
pp. 493-504 ◽  
Author(s):  
Laurent Hermoye ◽  
Christine Saint-Martin ◽  
Guy Cosnard ◽  
Seung-Koo Lee ◽  
Jinna Kim ◽  
...  
Keyword(s):  
Early Childhood ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Normal Database ◽  
White Matter Maturation

scholarly journals White matter structural connectivity and episodic memory in early childhood

2017 ◽  
Vol 28 ◽  
pp. 41-53 ◽  
Author(s):  
Chi T. Ngo ◽  
Kylie H. Alm ◽  
Athanasia Metoki ◽  
William Hampton ◽  
Tracy Riggins ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Episodic Memory ◽  
Structural Connectivity

scholarly journals Association between breastfeeding during infancy and white matter microstructure in early childhood

2021 ◽  
Author(s):  
Preeti Kar ◽  
Jess E. Reynolds ◽  
Melody N. Grohs ◽  
Rhonda C. Bell ◽  
Megan Jarman ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Diffusion Tensor ◽  
Total Duration ◽  
Sociodemographic Factors ◽  
Typically Developing ◽  
Brain White Matter ◽  
White Matter Microstructure ◽  
White Matter Development ◽  
Exclusive Or

Introduction: Associations between breastfeeding and brain development, in the context of child, perinatal, and sociodemographic variables, remain unclear. This study investigates whether exclusive breastfeeding for the first 6 months and total duration of any breastfeeding are associated with brain white matter microstructure in young children. Methods: This study included a sample of 83 mothers and 85 typically developing children (42 males). Children underwent their first diffusion tensor imaging scan between ages 2.34-6.97 years; some children returned multiple times, providing a total of 331 datasets. Feeding information was collected from the mothers at 3, 6, and 12 months postpartum and at their child's scan to calculate breastfeeding status at 6 months (exclusive or not) as well as total duration of any breastfeeding. Linear regression was used to investigate associations between breastfeeding exclusivity/duration and fractional anisotropy (FA, a measure sensitive to myelination/axonal packing/fibre coherence) for the whole brain and 10 individual white matter tracts. Results: Breastfeeding exclusivity and duration were associated with global and regional white matter microstructure, even after controlling for perinatal and sociodemographic factors. Greater exclusivity was associated with higher FA in females and lower FA in males. Conclusions: These findings suggest white matter differences associated with breastfeeding that differ by sex. These may stem from different trajectories in white matter development between males and females in early childhood and suggest possible long-term white matter differences associated with breastfeeding.

scholarly journals Global and regional white matter development in early childhood

NeuroImage ◽  
2019 ◽  
Vol 196 ◽  
pp. 49-58 ◽  
Author(s):  
Jess E. Reynolds ◽  
Melody N. Grohs ◽  
Deborah Dewey ◽  
Catherine Lebel
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
White Matter Development

Clinical and Neuroimaging Changes of Subacute Sclerosing Panencephalitis – Experience 30 Cases in Tertiary Care Center in Bangladesh

2021 ◽  
Vol 2 (3) ◽  
pp. 1-4
Author(s):  
Gopen Kumar Kundu ◽  
Mohammad Monir Hossain
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Subacute Sclerosing Panencephalitis ◽  
Tertiary Care ◽  
Stage Ii ◽  
Cortical Atrophy ◽  
Periventricular White Matter ◽  
History Of ◽  
Signal Changes ◽  
Intense Signal

Background: Subacute sclersing panencephalitis (SSPE) is a very rare progressive, fatal neurodegenerative disease of the control nervous system of childhood and early adolescence. It is a slow virus disease caused by persistent defective measles virus infection of the brain Objective: To see the clinical andneuro-imaging findings in children with Subacute sclerosing panencephalitis. Methods: This retrospective study was conducted at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, a tertiary care premier Postgraduate Medical Institution in Bangladesh. Thirty (30) Subacute sclerosing panencephalitis (SSPE) children were evaluated at paediatric neurology ward during the period January 2010 to December 2017. Diagnosis was based on typical clinical characteristic features, the presence of periodic discharges on EEG, demonstration of raised antibody titer against measles in the plasma and cerebrospinal fluid Detected by ELISA in all patients. Results: Total number of studied children were 30. Mean age was 10.2±3.1 year and Male female ratio was 5:1. Most of the patient arrived from poor socio-economic (83.33%) background of rural area (66.67%) of Bangladesh. Among them 46.67% had history of measles infection during early childhood. Progressive deterioration of school performance (50%), gait disturbance (70%), myoclonus (83%) dysarthria (43%) and Ocular manifestations like optic atrophy & papilledema (83.33%) were the main presenting feature of our studied children. All of the patients (100%) showed positive measles specific antibody IgG in CSF and On electroencephalographic findings showed periodic burst suppression in 90.90% cases. Most of the children (56.6%) were in stage II category and other 3.3%, 33.3%,6.6%, were stage I, stage III, stage IV category respectively. Neuroimaging study showed abnormalities in 45.83% cases included periventricular white matter hyper intense signal changes, cortical atrophy and ischaemic change. Conclusion: In our study most of the SSPE patient were in stage II.About half of the patient had history of measles infection during early childhood. Neuroimaging abnormalities found in about half of the cases and majority cases were in stage II. Common neuroimaging abnormalities were periventricular white matter hyper intense signal changes and cortical atrophy.

A review of diffusion MRI of typical white matter development from early childhood to young adulthood

2017 ◽  
Vol 32 (4) ◽  
pp. e3778 ◽  
Author(s):  
Catherine Lebel ◽  
Sarah Treit ◽  
Christian Beaulieu
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Young Adulthood ◽  
Diffusion Mri ◽  
White Matter Development

scholarly journals Early childhood development of white matter fiber density and morphology

2019 ◽  
Author(s):  
Dennis Dimond ◽  
Christiane S. Rohr ◽  
Robert E. Smith ◽  
Thijs Dhollander ◽  
Ivy Cho ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Fiber Bundle ◽  
Early Childhood Development ◽  
Diffusion Tensor ◽  
Childhood Development ◽  
Fiber Density ◽  
White Matter Maturation ◽  
One Year ◽  
Axonal Density

ABSTRACTEarly childhood is an important period for cognitive and brain development, though white matter changes specific to this period remain understudied. Here we utilize a novel analytic approach to quantify and track developmental changes in white matter micro- and macro-structure, calculated from individually oriented fiber-bundle populations, termed “fixels”. Fixel-based analysis and mixed-effects models were used to assess tract-wise changes in fiber density and bundle morphology in 73 girls scanned at baseline (ages 4.09-7.02, mean=5.47, SD=0.81), 6-month (N=7), and one-year follow-up (N=42). For comparison, we also assessed changes in commonly utilized diffusion tensor metrics: fractional anisotropy (FA), and mean, radial and axial diffusivity (MD, RD, AD). Maturational increases in fixel-metrics were seen in most major white matter tracts, with the most rapid increases in the corticospinal tract and slowest or non-significant increases in the genu of the corpus callosum and uncinate fasciculi. As expected, we observed developmental increases in FA and decreases in MD, RD and AD, though percentage changes were smaller relative to fixel-metrics. The majority of tracts showed more substantial morphological than microstructural changes. These findings highlight early childhood as a period of dynamic white matter maturation, characterized by large increases in macroscopic fiber bundle size, mild changes in axonal density, and parallel, albeit less substantial, changes in diffusion tensor metrics.

scholarly journals Characterizing longitudinal white matter development during early childhood

2014 ◽  
Vol 220 (4) ◽  
pp. 1921-1933 ◽  
Author(s):  
Douglas C. Dean ◽  
Jonathan O’Muircheartaigh ◽  
Holly Dirks ◽  
Nicole Waskiewicz ◽  
Lindsay Walker ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
White Matter Development

scholarly journals Links between white matter microstructure and cortisol reactivity to stress in early childhood: Evidence for moderation by parenting

2014 ◽  
Vol 6 ◽  
pp. 77-85 ◽  
Author(s):  
Haroon I. Sheikh ◽  
Marc F. Joanisse ◽  
Sarah M. Mackrell ◽  
Katie R. Kryski ◽  
Heather J. Smith ◽  
...  
Keyword(s):  
Early Childhood ◽  
White Matter ◽  
Cortisol Reactivity ◽  
White Matter Microstructure
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