scholarly journals In Patients with an α-Galactosidase A Variant, Small Nerve Fibre Assessment Cannot Confirm a Diagnosis of Fabry Disease

2015 ◽  
pp. 95-103 ◽  
Author(s):  
Linda van der Tol ◽  
Camiel Verhamme ◽  
Ivo N. van Schaik ◽  
Anneke J. van der Kooi ◽  
Carla E. M. Hollak ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Nerve Fibre ◽  
Small Nerve

The relation between small nerve fibre function, age, disease severity and pain in Fabry disease

2011 ◽  
Vol 15 (8) ◽  
pp. 822-829 ◽  
Author(s):  
Marieke Biegstraatenl ◽  
Andreas Binderl ◽  
Rainer Maagl ◽  
Carla E.M. Hollakl ◽  
Ralf Baronl ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Nerve Fibre ◽  
Disease Severity ◽  
Small Nerve

scholarly journals Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Jamie Burgess ◽  
Bernhard Frank ◽  
Andrew Marshall ◽  
Rashaad S. Khalil ◽  
Georgios Ponirakis ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Nerve Fibre ◽  
Diabetic Peripheral Neuropathy ◽  
Point Of Care ◽  
Unmet Need ◽  
Screening Tools ◽  
Nerve Fibres ◽  
Diagnostic Laboratory ◽  
Corneal Confocal Microscopy ◽  
Small Nerve

Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2 diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations impact drastically on quality of life, contributing to the individual, societal, financial and healthcare burden of diabetes. DPN is diagnosed at a late, often pre-ulcerative stage due to a lack of early systematic screening and the endorsement of monofilament testing which identifies advanced neuropathy only. Compared to the success of the diabetic eye and kidney screening programmes there is clearly an unmet need for an objective reliable biomarker for the detection of early DPN. This article critically appraises research and clinical methods for the diagnosis or screening of early DPN. In brief, functional measures are subjective and are difficult to implement due to technical complexity. Moreover, skin biopsy is invasive, expensive and lacks diagnostic laboratory capacity. Indeed, point-of-care nerve conduction tests are convenient and easy to implement however questions are raised regarding their suitability for use in screening due to the lack of small nerve fibre evaluation. Corneal confocal microscopy (CCM) is a rapid, non-invasive, and reproducible technique to quantify small nerve fibre damage and repair which can be conducted alongside retinopathy screening. CCM identifies early sub-clinical DPN, predicts the development and allows staging of DPN severity. Automated quantification of CCM with AI has enabled enhanced unbiased quantification of small nerve fibres and potentially early diagnosis of DPN. Improved screening tools will prevent and reduce the burden of foot ulceration and amputations with the primary aim of reducing the prevalence of this common microvascular complication.

Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity

2021 ◽  
Vol 45 (3) ◽  
pp. 631-638
Author(s):  
Shazli Azmi ◽  
Maryam Ferdousi ◽  
Yifen Liu ◽  
Safwaan Adam ◽  
Zohaib Iqbal ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Nerve Fibre ◽  
Small Nerve

Fibromyalgia syndrome—A laser‐evoked potentials study unsupportive of small nerve fibre involvement

2019 ◽  
Vol 24 (2) ◽  
pp. 448-456 ◽  
Author(s):  
Dominique C. F. Van Assche ◽  
Leon Plaghki ◽  
Etienne Masquelier ◽  
Samar M. Hatem
Keyword(s):  
Evoked Potentials ◽  
Nerve Fibre ◽  
Fibromyalgia Syndrome ◽  
Laser Evoked Potentials ◽  
Small Nerve

P464 Comparison of temperature threshold tests for the assessment of small nerve fibre dysfunction

1996 ◽  
Vol 99 (4) ◽  
pp. 382
Author(s):  
J. Reulen ◽  
A. v/d Zwan ◽  
F. Spaans ◽  
M. van Kleef ◽  
M. Hartmann
Keyword(s):  
Nerve Fibre ◽  
Temperature Threshold ◽  
Small Nerve

Patients with severe hypertriglyceridaemia have neuropathy and small nerve fibre damage

2020 ◽  
Vol 315 ◽  
pp. e162-e163
Author(s):  
L. D’Onofrio ◽  
A. Kalteniece ◽  
Z. Iqbal ◽  
S. Adam ◽  
J.H. Ho ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Small Nerve

The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathy

2002 ◽  
Vol 39 (1) ◽  
pp. 1-6 ◽  
Author(s):  
T. Forst ◽  
T. Pohlmann ◽  
T. Kunt ◽  
K. Goitom ◽  
G. Schulz ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Nerve Fibre ◽  
Small Nerve

scholarly journals The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shazli Azmi ◽  
Maryam Ferdousi ◽  
Yifen Liu ◽  
Safwaan Adam ◽  
Tarza Siahmansur ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Nerve Fibre ◽  
Cholesterol Efflux ◽  
Severe Obesity ◽  
Apolipoprotein A1 ◽  
Healthy Controls ◽  
Serum Triglycerides ◽  
Amyloid A ◽  
Hdl Functionality ◽  
Small Nerve

AbstractObesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome and lipoprotein abnormalities. 47participants with severe obesity and 30 age-matched healthy controls underwent detailed phenotyping of neuropathy and an assessment of lipoproteins and HDL-functionality. Participants with severe obesity had a higher neuropathy symptom profile, lower sural and peroneal nerve amplitudes, abnormal thermal thresholds, heart rate variability with deep breathing and corneal nerve parameters compared to healthy controls. Circulating apolipoprotein A1 (P = 0.009), HDL cholesterol (HDL-C) (P < 0.0001), cholesterol efflux (P = 0.002) and paroxonase-1 (PON-1) activity (P < 0.0001) were lower, and serum amyloid A (SAA) (P < 0.0001) was higher in participants with obesity compared to controls. Obese participants with small nerve fibre damage had higher serum triglycerides (P = 0.02), lower PON-1 activity (P = 0.002) and higher prevalence of metabolic syndrome (58% vs. 23%, P = 0.02) compared to those without. However, HDL-C (P = 0.8), cholesterol efflux (P = 0.08), apoA1 (P = 0.8) and SAA (P = 0.8) did not differ significantly between obese participants with and without small nerve fibre damage. Small nerve fibre damage occurs in people with severe obesity. Patients with obesity have deranged lipoproteins and compromised HDL functionality compared to controls. Obese patients with evidence of small nerve fibre damage, compared to those without, had significantly higher serum triglycerides, lower PON-1 activity and a higher prevalence of metabolic syndrome.

scholarly journals Corneal confocal microscopy detects small nerve fibre damage in patients with painful diabetic neuropathy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alise Kalteniece ◽  
Maryam Ferdousi ◽  
Shazli Azmi ◽  
Womba M. Mubita ◽  
Andrew Marshall ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Diabetic Neuropathy ◽  
Nerve Fibre ◽  
Painful Diabetic Neuropathy ◽  
Corneal Confocal Microscopy ◽  
Small Nerve
Sign in / Sign up

Export Citation Format

Share Document