Fibromyalgia syndrome—A laser‐evoked potentials study unsupportive of small nerve fibre involvement

2019 ◽  
Vol 24 (2) ◽  
pp. 448-456 ◽  
Author(s):  
Dominique C. F. Van Assche ◽  
Leon Plaghki ◽  
Etienne Masquelier ◽  
Samar M. Hatem
Keyword(s):  
Evoked Potentials ◽  
Nerve Fibre ◽  
Fibromyalgia Syndrome ◽  
Laser Evoked Potentials ◽  
Small Nerve

Suggestion and Pain in Migraine: A Study by Laser Evoked Potentials

2012 ◽  
Vol 11 (2) ◽  
pp. 110-126 ◽  
Author(s):  
Marina de Tommaso ◽  
Antonio Federici ◽  
Giovanni Franco ◽  
Katia Ricci ◽  
Marta Lorenzo ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Laser Evoked Potentials

scholarly journals Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Jamie Burgess ◽  
Bernhard Frank ◽  
Andrew Marshall ◽  
Rashaad S. Khalil ◽  
Georgios Ponirakis ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Nerve Fibre ◽  
Diabetic Peripheral Neuropathy ◽  
Point Of Care ◽  
Unmet Need ◽  
Screening Tools ◽  
Nerve Fibres ◽  
Diagnostic Laboratory ◽  
Corneal Confocal Microscopy ◽  
Small Nerve

Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2 diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations impact drastically on quality of life, contributing to the individual, societal, financial and healthcare burden of diabetes. DPN is diagnosed at a late, often pre-ulcerative stage due to a lack of early systematic screening and the endorsement of monofilament testing which identifies advanced neuropathy only. Compared to the success of the diabetic eye and kidney screening programmes there is clearly an unmet need for an objective reliable biomarker for the detection of early DPN. This article critically appraises research and clinical methods for the diagnosis or screening of early DPN. In brief, functional measures are subjective and are difficult to implement due to technical complexity. Moreover, skin biopsy is invasive, expensive and lacks diagnostic laboratory capacity. Indeed, point-of-care nerve conduction tests are convenient and easy to implement however questions are raised regarding their suitability for use in screening due to the lack of small nerve fibre evaluation. Corneal confocal microscopy (CCM) is a rapid, non-invasive, and reproducible technique to quantify small nerve fibre damage and repair which can be conducted alongside retinopathy screening. CCM identifies early sub-clinical DPN, predicts the development and allows staging of DPN severity. Automated quantification of CCM with AI has enabled enhanced unbiased quantification of small nerve fibres and potentially early diagnosis of DPN. Improved screening tools will prevent and reduce the burden of foot ulceration and amputations with the primary aim of reducing the prevalence of this common microvascular complication.

Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity

2021 ◽  
Vol 45 (3) ◽  
pp. 631-638
Author(s):  
Shazli Azmi ◽  
Maryam Ferdousi ◽  
Yifen Liu ◽  
Safwaan Adam ◽  
Zohaib Iqbal ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Nerve Fibre ◽  
Small Nerve

Focal Mechanical Vibration Does not Change Laser-Pain Perception and Laser-Evoked Potentials: A Pilot Study

Pain Practice ◽  
2016 ◽  
Vol 17 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Costanza Pazzaglia ◽  
Filippo Camerota ◽  
Claudia Celletti ◽  
Ileana Minciotti ◽  
Elisa Testani ◽  
...  
Keyword(s):  
Pilot Study ◽  
Evoked Potentials ◽  
Pain Perception ◽  
Mechanical Vibration ◽  
Laser Evoked Potentials

Dyspnea-pain counterirritation induced by inspiratory threshold loading: a laser-evoked potentials study

2012 ◽  
Vol 112 (7) ◽  
pp. 1166-1173 ◽  
Author(s):  
Guillaume Bouvier ◽  
Louis Laviolette ◽  
Felix Kindler ◽  
Lionel Naccache ◽  
André Mouraux ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Normal Male ◽  
Work Effort ◽  
Top Down ◽  
Laser Evoked Potentials ◽  
Brain Potentials ◽  
Nociceptive Flexion Reflex ◽  
Electrical Stimuli ◽  
Experimentally Induced

Background: experimentally induced dyspnea of the work/effort type inhibits, in a top-down manner, the spinal transmission of nociceptive inputs (dyspnea-pain counterirritation). Previous studies have demonstrated that this inhibition can be assessed by measuring the nociceptive flexion reflex (RIII). However, its clinical application is limited because of the strong discomfort associated with the electrical stimuli required to elicit the RIII reflex. Study objectives: we examined whether the dyspnea-pain counterirritation phenomenon can be evaluated by measuring the effect of work/effort type dyspnea on the magnitude of laser-evoked brain potentials (LEPs). Methods: 10 normal male volunteers were studied (age: 19–30 years). LEPs were elicited using a CO2 laser stimulator delivering 10- to 15-ms stimuli of 6 ± 0.7 W over a 12.5 mm2 area. The EEG was recorded using nine scalp channels. Non-nociceptive somatosensory-evoked potentials (SEPs) served as control. LEPs and SEPs were recorded before, during, and after 10 min of experimentally induced dyspnea [inspiratory threshold loading (ITL)]. Results: pain caused by the nociceptive laser stimulus was mild. ITL consistently induced dyspnea, mostly of the “excessive effort” type. Amplitude of the N2-P2 wave of LEPs decreased by 37.6 ± 13.8% during ITL and was significantly correlated with the intensity of dyspnea [ r = 0.66, CI 95% (0.08–0.92, P = 0.0319)]. In contrast, ITL had no effect on the magnitude of non-nociceptive SEPs. Discussion: experimentally induced dyspnea of the work/effort type reduces the magnitude of LEPs. This reduction correlates with the intensity of dyspnea. The recording of LEPs could constitute a clinically applicable approach to assess the dyspnea-pain counterirritation phenomenon in patients.

Laser evoked potentials for assessing sensory neuropathy in human patients

2004 ◽  
Vol 361 (1-3) ◽  
pp. 25-28 ◽  
Author(s):  
A. Truini ◽  
A. Romaniello ◽  
F. Galeotti ◽  
G.D. Iannetti ◽  
G. Cruccu
Keyword(s):  
Evoked Potentials ◽  
Sensory Neuropathy ◽  
Laser Evoked Potentials
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