Synthesis of Novel Chain Extended and Crosslinked Polylactones for Tissue Regeneration and Controlled Release Applications

2011 ◽  
pp. 409-438 ◽  
Author(s):  
Jukka Seppälä ◽  
Harri Korhonen ◽  
Risto Hakala ◽  
Minna Malin
Keyword(s):  
Controlled Release ◽  
Tissue Regeneration

scholarly journals Biocomposite nanofibrous strategies for the controlled release of biomolecules for skin tissue regeneration

2014 ◽  
pp. 4709 ◽  
Author(s):  
Dinesh Kumar Srinivasan ◽  
Chinnasamy Gandhimathi ◽  
Jayarama Reddy Venugopal ◽  
Velmurugan Bhaarathy ◽  
Seeram Ramakrishna
Keyword(s):  
Controlled Release ◽  
Tissue Regeneration ◽  
Skin Tissue

Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration

Biomaterials ◽  
2006 ◽  
Vol 27 (34) ◽  
pp. 5836-5844 ◽  
Author(s):  
Hossein Hosseinkhani ◽  
Mohsen Hosseinkhani ◽  
Ali Khademhosseini ◽  
Hisatoshi Kobayashi ◽  
Yasuhiko Tabata
Keyword(s):  
Controlled Release ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Tissue Regeneration ◽  
Fibroblast Growth ◽  
Peptide Amphiphile

Bioadditive Manufacturing of Hybrid Tissue Scaffolds for Controlled Release Kinetics

2012 ◽  
Author(s):  
Ibrahim T. Ozbolat ◽  
A. K. M. B. Khoda ◽  
Bahattin Koc
Keyword(s):  
Controlled Release ◽  
Tissue Regeneration ◽  
Manufacturing System ◽  
Fluid Transport ◽  
Release Kinetics ◽  
Base Material ◽  
Tissue Scaffolds ◽  
Cell Protein ◽  
Hybrid Scaffolds ◽  
Internal Architecture

Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue with the release kinetics of loaded biomolecules. This might be an engineering challenge and promising approach for improved and efficient tissue regeneration. The most critical limitations: the selection of proper protein(s) incorporation, and precise control over concentration gradient and timing should be overcome. Hence, tissue scaffolds need to be fabricated in a way that proteins or growth factors should be incorporated and released in a specific spatial and temporal orientation to mimic the natural tissue regeneration process. Spatial and temporal control over heterogeneous porous tissue scaffolds can be achieved by controlling two important parameters: (i) internal architecture with enhanced fluid transport, and (ii) distribution of scaffold base material and loaded modifiers. In this research, heterogeneous tissue scaffolds are designed considering both the parameters. Firstly, the three-dimensional porous structures of the scaffold are geometrically partition into functionally uniform porosity regions and controlled spatial micro-architecture has been achieved using a functionally gradient porosity function. The bio-fabrication of the designed internal porous architecture has been performed using a single nozzle bioadditive manufacturing system. The internal architecture scheme is developed to enhance fluid transport with continuous base material deposition. Next, the hybrid tissue scaffolds are modeled with varying material characteristics to mediate the release of base material and enclosed biological modifiers are proposed based on tissue engineering requirements. The hybrid scaffolds are fabricated for spatial control of biomolecules and base material to synchronize the release kinetics with tissue regeneration. A pressure-assisted multi-chamber single nozzle bioadditive manufacturing system is used to fabricate hybrid scaffolds.

scholarly journals Efficacy of the Controlled Release of Concentrated Platelet Lysate from a Collagen/Gelatin Scaffold for Dermis-Like Tissue Regeneration

2013 ◽  
Vol 19 (11-12) ◽  
pp. 1398-1405 ◽  
Author(s):  
Ran Ito ◽  
Naoki Morimoto ◽  
Liem Hieu Pham ◽  
Tsuguyoshi Taira ◽  
Katsuya Kawai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Tissue Regeneration ◽  
Platelet Lysate

scholarly journals Self-Assembling Peptides and Their Application in the Treatment of Diseases

2019 ◽  
Vol 20 (23) ◽  
pp. 5850 ◽  
Author(s):  
Lee ◽  
Trinh ◽  
Yoo ◽  
Shin ◽  
Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Side Effects ◽  
Tissue Regeneration ◽  
Environmental Conditions ◽  
Self Assembly ◽  
Basic Structure ◽  
Physicochemical Characteristics ◽  
Self Assembling ◽  
Structural Divergence

Self-assembling peptides are biomedical materials with unique structures that are formed in response to various environmental conditions. Governed by their physicochemical characteristics, the peptides can form a variety of structures with greater reactivity than conventional non-biological materials. The structural divergence of self-assembling peptides allows for various functional possibilities; when assembled, they can be used as scaffolds for cell and tissue regeneration, and vehicles for drug delivery, conferring controlled release, stability, and targeting, and avoiding side effects of drugs. These peptides can also be used as drugs themselves. In this review, we describe the basic structure and characteristics of self-assembling peptides and the various factors that affect the formation of peptide-based structures. We also summarize the applications of self-assembling peptides in the treatment of various diseases, including cancer. Furthermore, the in-cell self-assembly of peptides, termed reverse self-assembly, is discussed as a novel paradigm for self-assembling peptide-based nanovehicles and nanomedicines.

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