The Role of Two-Component Signal Transduction Systems in Staphylococcus aureus Virulence Regulation

2015 ◽  
pp. 145-198 ◽  
Author(s):  
Andreas F. Haag ◽  
Fabio Bagnoli
Keyword(s):  
Signal Transduction ◽  
Staphylococcus Aureus ◽  
Virulence Regulation ◽  
Two Component ◽  
Two Component Signal Transduction ◽  
Signal Transduction Systems

scholarly journals Global Regulation of Gene Expression by ArlRS, a Two-Component Signal Transduction Regulatory System of Staphylococcus aureus

2005 ◽  
Vol 187 (15) ◽  
pp. 5486-5492 ◽  
Author(s):  
Xudong Liang ◽  
Li Zheng ◽  
Christina Landwehr ◽  
Dwayne Lunsford ◽  
David Holmes ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Staphylococcus Aureus ◽  
Microarray Data ◽  
Regulation Of Gene Expression ◽  
Regulatory System ◽  
Transcriptional Regulators ◽  
Microarray Technology ◽  
Two Component ◽  
Two Component Signal Transduction ◽  
Signal Transduction Systems

ABSTRACT Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional regulators. In this study, we used microarray technology to identify the genes regulated by ArlR. The microarray data indicate that ArlR functions as a positive regulator and also as a negative repressor to directly and/or indirectly mediate the expression of at least 114 genes involved in different functions, including autolysis, cell division, growth, and pathogenesis.

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