scholarly journals Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease

2015 ◽  
pp. 29-39 ◽  
Author(s):  
Francesca Aguilo ◽  
Serena Di Cecilia ◽  
Martin J. Walsh
Keyword(s):  
Cardiovascular Disease ◽  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers

2020 ◽  
Vol Volume 13 ◽  
pp. 6393-6403
Author(s):  
Wei Han ◽  
Jia Shi ◽  
Jiachao Cao ◽  
Bo Dong ◽  
Wei Guan
Keyword(s):  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract 051: A Panel of CRISPR/Cas9 Genome Edited Rat Models Define Quantitative Trait Nucleotides within a Novel Rat Long Non-coding RNA Implicated in Cardiovascular Disease

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Xi Cheng ◽  
Harshal Waghulde ◽  
Blair Mell ◽  
Shondra Miller ◽  
Wanda Filipiak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Quantitative Trait ◽  
Qt Interval ◽  
Chromosome 17 ◽  
Insertion Polymorphism ◽  
Non Coding Rna ◽  
Trait Locus ◽  
Human Chromosome 17 ◽  
Long Non Coding Rna

This study is focused on a GWAS locus for cardiovascular disease (QT-interval) on human chromosome 17. The homologous genomic segment of this human locus was previously mapped with high resolution to <42.5 kb on rat chromosome 10. The locus in rats regulates both QT-interval and blood pressure and contains a novel long non-coding RNA (lncRNA), with a large 19bp deletion/insertion polymorphism observed between the strains used to map the locus. Characterization of this novel lncRNA using rapid amplification of cDNA ends (RACE) provided evidence for the presence of more than a single isoform of the lncRNA. To further assess the role of this locus, a panel of CRISPR/Cas9 based gene-edited ‘knockout’ models of the lncRNA was developed. The lncRNA targeted rats were developed on the genomic background of the hypertensive Dahl salt-sensitive rats and harbored varied disruptions around the critical 19bp region. The rat strains with the disrupted lncRNA sequences had a significantly elevated blood pressure compared with the controls. QT-interval is currently being examined. Overall, this is the first demonstration of a CRISPR/Cas9 based targeted gene-editing approach applied to identify a novel lncRNA as a Blood Pressure Quantitative Trait Locus.

scholarly journals UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S90-S90
Author(s):  
Zheng Kuai ◽  
Meiting Chen ◽  
yang yu ◽  
Fan Yang ◽  
chunxiang Zhang
Keyword(s):  
Cardiovascular Disease ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Cardiac Myocyte ◽  
Diagnostic Biomarker ◽  
Over Expression ◽  
Non Coding Rna ◽  
Organ Level ◽  
Long Non Coding Rna ◽  
Over Time

Abstract Aging is the inevitable, irreversible decline in function on the cellular and organ level leading to increased incidence of the most frequent diseases such as cancer and cardiovascular disease, that occurs over time. whereas the molecular mechanisms of senescence remain largely unknown. Here we identified that a novel long noncoding RNA, Morrbid was significantly decreased in different organs of aged mice, such as heart, liver, spleen, lung, kidney and brain. Interestingly, the telomeres length of Morrbid KO mice were significantly shorted than the WT mice at the same age. We also found that Morrbid was steeply decreased in a natural mouse cardiac myocyte senescence model. The senescence of mouse cardiac myocytes was effectively attenuated by Morrbid over-expression shown by the decreased β-galactosidase staining, increased telomere activity, decreased production of ROS and decreased cell apoptosis, but was enhanced by Morrbid knockdown. The results suggest that Morrbid is a critical regulator in senescence and could be used as a novel diagnostic biomarker for it, and a new therapeutic target for diverse diseases.

scholarly journals MALAT1: A long non‑coding RNA highly associated with human cancers (Review)

2018 ◽  
Author(s):  
Miaomiao Zhao ◽  
Songpo Wang ◽  
Qi Li ◽  
Qing Ji ◽  
Piaoting Guo ◽  
...  
Keyword(s):  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals LINC00152: A pivotal oncogenic long non-coding RNA in human cancers

2017 ◽  
Vol 50 (4) ◽  
pp. e12349 ◽  
Author(s):  
Yang Yu ◽  
Jian Yang ◽  
Quanpeng Li ◽  
Boming Xu ◽  
Yifan Lian ◽  
...  
Keyword(s):  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals BANCR: a novel oncogenic long non-coding RNA in human cancers

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94997-95004 ◽  
Author(s):  
Yifan Zou ◽  
Jianfa Li ◽  
Yincong Chen ◽  
Huizhong Xiao ◽  
Fuyou Zhang ◽  
...  
Keyword(s):  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Prognostic and clinicopathological roles of long non-coding RNA XIST in human cancers: a meta-analysis

2018 ◽  
Vol 7 (6) ◽  
pp. 1624-1633 ◽  
Author(s):  
Liang Shen ◽  
Changzhong Li ◽  
Ming Liu ◽  
Deying Wei ◽  
Qin Chang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Human Cancers ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA HEIH: a novel tumor activator in multiple cancers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie-yu Sun ◽  
Ming-ming Ni
Keyword(s):  
Tumor Stage ◽  
Advanced Tumor Stage ◽  
Altered Expression ◽  
Human Cancers ◽  
Advanced Tumor ◽  
Non Coding Rna ◽  
Different Types ◽  
Recent Developments ◽  
Underlying Mechanisms ◽  
Long Non Coding Rna

AbstractThe last decade has witnessed the altered expression levels of long non-coding RNA HEIH in different types of cancer. More than half of the HEIH studies in cancer have been published within the last two years. To our knowledge, this is the first review to discuss very recent developments and insights into HEIH contribution to carcinogenesis. The functional role, molecular mechanism, and clinical significance of HEIH in human cancers are described in detail. The expression of HEIH is elevated in a broad spectrum of cancers, and its disorder contributes to cell proliferation, migration, invasion, and drug resistance of cancer cells through different underlying mechanisms. In addition, the high expression of HEIH is significantly associated with advanced tumor stage, tumor size and decreased overall survival, suggesting HEIH may function as a prognostic biomarker and potential therapeutic target for human cancers.

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