TUSC7: A novel tumor suppressor long non-coding RNA in human cancers

2018 ◽  
Vol 233 (9) ◽  
pp. 6401-6407 ◽  
Author(s):  
Na Li ◽  
Ke Shi ◽  
Wei Li
Tumor Biology ◽  
2016 ◽  
Vol 37 (5) ◽  
pp. 5657-5661 ◽  
Author(s):  
Zheng Li ◽  
Xin Yu ◽  
Jianxiong Shen

2020 ◽  
Vol Volume 13 ◽  
pp. 6393-6403
Author(s):  
Wei Han ◽  
Jia Shi ◽  
Jiachao Cao ◽  
Bo Dong ◽  
Wei Guan

2019 ◽  
Vol 40 (8) ◽  
pp. 956-964 ◽  
Author(s):  
Chao Yang ◽  
Lin Wang ◽  
Jia Sun ◽  
Jun-hu Zhou ◽  
Yan-li Tan ◽  
...  

Abstract Long non-coding RNAs (lncRNAs) have been reported to play important roles in glioma; however, most of them promote glioma progression. We constructed a competing endogenous (ceRNA) network based on the Chinese Glioma Genome Atlas dataset, and lncRNA hect domain and RLD 2 pseudogene 2 (HERC2P2) is the core of this network. Highly connected genes in the ceRNA network classified the glioma patients into three clusters with significantly different survival rates. The expression of HERC2P2 is positively correlated with survival and negatively correlated with clinical grade. Cell colony formation, Transwell and cell scratch tests were performed to evaluate the role of HERC2P2 in glioblastoma growth. Furthermore, we overexpressed HERC2P2 in U87 cells and established a mouse intracranial glioma model to examine the function of HERC2P2 in vivo. In conclusion, we identified a lncRNA with tumor suppressor functions in glioma that could be a potential biomarker for glioma patients.


Author(s):  
Miaomiao Zhao ◽  
Songpo Wang ◽  
Qi Li ◽  
Qing Ji ◽  
Piaoting Guo ◽  
...  

2017 ◽  
Vol 50 (4) ◽  
pp. e12349 ◽  
Author(s):  
Yang Yu ◽  
Jian Yang ◽  
Quanpeng Li ◽  
Boming Xu ◽  
Yifan Lian ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94997-95004 ◽  
Author(s):  
Yifan Zou ◽  
Jianfa Li ◽  
Yincong Chen ◽  
Huizhong Xiao ◽  
Fuyou Zhang ◽  
...  

RSC Advances ◽  
2017 ◽  
Vol 7 (78) ◽  
pp. 49710-49719 ◽  
Author(s):  
Pei Wang ◽  
Dong Chen ◽  
Hongbing Ma ◽  
Yong Li

Long non-coding RNA (lncRNA) MEG3 has been identified as a tumor suppressor in various cancers including non-small cell lung cancer (NSCLC).


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