Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis

2012 ◽  
pp. 3-32 ◽  
Author(s):  
Mateusz S. Wietecha ◽  
Wendy L. Cerny ◽  
Luisa A. DiPietro
Keyword(s):  
Vessel Regression

scholarly journals Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression

Angiogenesis ◽  
2021 ◽  
Author(s):  
Delphine M. Lees ◽  
Louise E. Reynolds ◽  
Ana Rita Pedrosa ◽  
Marina Roy-Luzarraga ◽  
Kairbaan M. Hodivala-Dilke
Keyword(s):  
Blood Vessel ◽  
Tumour Growth ◽  
Vascular Endothelial Cell ◽  
Vessel Density ◽  
In Vivo Studies ◽  
Blood Vessel Density ◽  
Tumour Vessel ◽  
Vessel Regression ◽  
Tumour Blood

AbstractFocal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed in many cancer types and in vivo studies have shown that vascular endothelial cell FAK expression and FAK-phosphorylation at tyrosine (Y) 397, and subsequently FAK-Y861, are important in tumour angiogenesis. Pericytes also play a vital role in regulating tumour blood vessel stabilisation, but the specific involvement of pericyte FAK-Y397 and FAK-Y861 phosphorylation in tumour blood vessels is unknown. Using PdgfrβCre + ;FAKWT/WT, PdgfrβCre + ;FAKY397F/Y397F and PdgfrβCre + ;FAKY861F/Y861F mice, our data demonstrate that tumour growth, tumour blood vessel density, blood vessel perfusion and pericyte coverage were affected only in late stage tumours in PdgfrβCre + ;FAKY861F/Y861F but not PdgfrβCre + ;FAKY397F/Y397F mice. Further examination indicates a dual role for pericyte FAK-Y861 phosphorylation in the regulation of tumour vessel regression and also in the control of pericyte derived signals that influence apoptosis in cancer cells. Overall this study identifies the role of pericyte FAK-Y861 in the regulation of tumour vessel regression and tumour growth control and that non-phosphorylatable FAK-Y861F in pericytes reduces tumour growth and blood vessel density.

Vessel Regression

2010 ◽  
pp. 300-306
Author(s):  
H.-P. Hammes
Keyword(s):  
Vessel Regression

scholarly journals Correction: Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

PLoS Biology ◽  
2015 ◽  
Vol 13 (5) ◽  
pp. e1002163 ◽  
Author(s):  
Claudio A. Franco ◽  
Martin L. Jones ◽  
Miguel O. Bernabeu ◽  
Ilse Geudens ◽  
Thomas Mathivet ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Vessel Regression

scholarly journals Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

PLoS Biology ◽  
2015 ◽  
Vol 13 (4) ◽  
pp. e1002125 ◽  
Author(s):  
Claudio A. Franco ◽  
Martin L. Jones ◽  
Miguel O. Bernabeu ◽  
Ilse Geudens ◽  
Thomas Mathivet ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Vessel Regression

scholarly journals Contribution of cell death signaling to blood vessel formation

2021 ◽  
Vol 78 (7) ◽  
pp. 3247-3264
Author(s):  
Nathalie Tisch ◽  
Carmen Ruiz de Almodóvar
Keyword(s):  
Cell Death ◽  
Blood Vessel ◽  
Vascular System ◽  
Current Knowledge ◽  
Surrounding Tissue ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Vessel Remodeling ◽  
Vessel Regression ◽  
Cell Death Signaling

AbstractThe formation of new blood vessels is driven by proliferation of endothelial cells (ECs), elongation of maturing vessel sprouts and ultimately vessel remodeling to create a hierarchically structured vascular system. Vessel regression is an essential process to remove redundant vessel branches in order to adapt the final vessel density to the demands of the surrounding tissue. How exactly vessel regression occurs and whether and to which extent cell death contributes to this process has been in the focus of several studies within the last decade. On top, recent findings challenge our simplistic view of the cell death signaling machinery as a sole executer of cellular demise, as emerging evidences suggest that some of the classic cell death regulators even promote blood vessel formation. This review summarizes our current knowledge on the role of the cell death signaling machinery with a focus on the apoptosis and necroptosis signaling pathways during blood vessel formation in development and pathology.

scholarly journals Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis

Development ◽  
2016 ◽  
Vol 143 (16) ◽  
pp. 2973-2982 ◽  
Author(s):  
Emma C. Watson ◽  
Monica N. Koenig ◽  
Zoe L. Grant ◽  
Lachlan Whitehead ◽  
Evelyn Trounson ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Vessel Diameter ◽  
Cell Number ◽  
Capillary Vessel ◽  
Retinal Angiogenesis ◽  
Vessel Regression
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