Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?

2014 ◽  
pp. 237-270 ◽  
Author(s):  
Carolina Cebrián ◽  
John D. Loike ◽  
David Sulzer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stress Response ◽  
Animal Models ◽  
Cell Stress ◽  
A Cell ◽  
Cell Stress Response

Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response

2011 ◽  
Vol 10 (4) ◽  
pp. 1860-1869 ◽  
Author(s):  
Kim Y. C. Fung ◽  
Gemma V. Brierley ◽  
Steve Henderson ◽  
Peter Hoffmann ◽  
Shaun R. McColl ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stress Response ◽  
Cancer Cells ◽  
Cell Stress ◽  
Colorectal Cancer Cells ◽  
A Cell ◽  
Induced Apoptosis ◽  
Cell Stress Response

scholarly journals A cell-based assay system for activators of the environmental cell stress response

2020 ◽  
Vol 592 ◽  
pp. 113583
Author(s):  
Jennifer A. Harbottle ◽  
Linda Petrie ◽  
Madeleine Ruhe ◽  
Wael E. Houssen ◽  
Marcel Jaspars ◽  
...  
Keyword(s):  
Stress Response ◽  
Cell Stress ◽  
Assay System ◽  
Environmental Cell ◽  
A Cell ◽  
Cell Stress Response

scholarly journals Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson’s disease: a systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Keya Li ◽  
Xinyue Li ◽  
Guiying Shi ◽  
Xuepei Lei ◽  
Yiying Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Therapeutic Option ◽  
Meta Analysis ◽  
Future Application ◽  
Neuroprotective Effects ◽  
Standard Mean Difference ◽  
Study Characteristics

AbstractAnimal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells (ADSCs). Previous studies have evaluated the effects of primitive and induced ADSCs in animal models of Parkinson’s disease (PD). Here, eight databases were systematically searched for studies on the effects and in vivo changes caused by ADSC intervention. Quality assessment was conducted using a 10-item risk of bias tool. For the subsequent meta-analysis, study characteristics were extracted and effect sizes were computed. Ten out of 2324 published articles (n = 169 animals) were selected for further meta-analysis. After ADSC therapy, the rotation behavior (10 experiments, n = 156 animals) and rotarod performance (3 experiments, n = 54 animals) were improved (P < 0.000 01 and P = 0.000 3, respectively). The rotation behavior test reflected functional recovery, which may be due to the neurogenesis from neuronally differentiated ADSCs, resulting in a higher pooled effect size of standard mean difference (SMD) (− 2.59; 95% CI, − 3.57 to − 1.61) when compared to that of primitive cells (− 2.18; 95% CI, − 3.29 to − 1.07). Stratified analyses by different time intervals indicated that ADSC intervention exhibited a long-term effect. Following the transplantation of ADSCs, tyrosine hydroxylase-positive neurons recovered in the lesion area with pooled SMD of 13.36 [6.85, 19.86]. Transplantation of ADSCs is a therapeutic option that shows long-lasting effects in animal models of PD. The potential mechanisms of ADSCs involve neurogenesis and neuroprotective effects. The standardized induction of neural form of transplanted ADSCs can lead to a future application in clinical practice.

Antidyskinetic effect of A2Aand 5HT1A/1Breceptor ligands in two animal models of Parkinson's disease

2016 ◽  
Vol 31 (4) ◽  
pp. 501-511 ◽  
Author(s):  
Annalisa Pinna ◽  
Wai Kin D. Ko ◽  
Giulia Costa ◽  
Elisabetta Tronci ◽  
Camino Fidalgo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models

10. Investigation of neuronal cell stress response to transient freezing associated with cryosurgical ablation of the prostate

Cryobiology ◽  
2010 ◽  
Vol 61 (3) ◽  
pp. 364 ◽  
Author(s):  
John M. Baust ◽  
Kristi K. Snyder ◽  
Andrew Gage ◽  
Robert G. Van Buskirk ◽  
John G. Baust
Keyword(s):  
Stress Response ◽  
Neuronal Cell ◽  
Cell Stress ◽  
Cell Stress Response ◽  
Cryosurgical Ablation

scholarly journals Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Kyota Fujita ◽  
Yusaku Nakabeppu ◽  
Mami Noda
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Animal Studies ◽  
Clinical Symptoms ◽  
Therapeutic Effects ◽  
Therapeutic Approaches ◽  
Cellular Apoptosis ◽  
6 Hydroxydopamine

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.

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