Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response

2011 ◽  
Vol 10 (4) ◽  
pp. 1860-1869 ◽  
Author(s):  
Kim Y. C. Fung ◽  
Gemma V. Brierley ◽  
Steve Henderson ◽  
Peter Hoffmann ◽  
Shaun R. McColl ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stress Response ◽  
Cancer Cells ◽  
Cell Stress ◽  
Colorectal Cancer Cells ◽  
A Cell ◽  
Induced Apoptosis ◽  
Cell Stress Response

scholarly journals The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yasamin Dabiri ◽  
Sara Kalman ◽  
Clara-Marie Gürth ◽  
Jee Young Kim ◽  
Viola Mayer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Essential Role ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis

Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis

2018 ◽  
Vol 233 (7) ◽  
pp. 5458-5467 ◽  
Author(s):  
Hsi-Hsien Hsu ◽  
Ming-Cheng Chen ◽  
Rathinasamy Baskaran ◽  
Yueh-Min Lin ◽  
Cecilia H. Day ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis

scholarly journals miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

2020 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
P53 Expression ◽  
Colorectal Cancer Cells ◽  
Scratch Wound ◽  
And Migration ◽  
Induced Apoptosis ◽  
Ht 29 ◽  
Human Colorectal Cancer Cells

Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells were treated with DOX. Cell viability, apoptosis, and migration were evaluated by MTT, flow cytometry, and scratch-wound motility assays, respectively. Furthermore, the expression level of miR-214 and p53 was evaluated by qRT-PCR. Results: miR-214 transfection significantly inhibited the cell proliferation rate (P<0.05), induced apoptosis (P<0.05), and harnessed migration (P<0.05) in the HT-29 cells after 48 h. Furthermore, more effectiveness was observed in combination with DOX. Additionally, miR-214 transfection led to a reduction in p53 expression offering that it might be a potential target for miR-214. Conclusion: In conclusion, miR-214 sensitizes HT-29 cells to doxorubicin by targeting p53 indicating the significant role of this miRNA in colorectal cancer chemotherapy.

Transfection of PDCD5 sensitizes colorectal cancer cells to cisplatin-induced apoptosis in vitro and in vivo

2010 ◽  
Vol 649 (1-3) ◽  
pp. 120-126 ◽  
Author(s):  
Anning Yin ◽  
Yingan Jiang ◽  
Xianfeng Zhang ◽  
Juan Zhao ◽  
Hesheng Luo
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis

scholarly journals Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis

2014 ◽  
Vol 46 (3) ◽  
pp. 1121-1130 ◽  
Author(s):  
SE-LIM KIM ◽  
YU-CHUAN LIU ◽  
YOUNG RAN PARK ◽  
SEUNG YOUNG SEO ◽  
SEONG HUN KIM ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colorectal Cancer Cells ◽  
Induced Apoptosis
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