scholarly journals Genetic Factors Modulating the Response to Stimulant Drugs in Humans

2011 ◽  
pp. 537-577 ◽  
Author(s):  
Amy B. Hart ◽  
Harriet de Wit ◽  
Abraham A. Palmer
Keyword(s):  
Genetic Factors ◽  
Stimulant Drugs

Genetic Factors in the Etiology of Duodenal Ulcer

1961 ◽  
Vol 40 (3) ◽  
pp. 371-378 ◽  
Author(s):  
David A. Price Evans
Keyword(s):  
Duodenal Ulcer ◽  
Genetic Factors

Stimulant Drugs-Medical Needs, Alternative Indications, and Related Problems

1993 ◽  
Author(s):  
Jonathan O. Cole ◽  
◽  
Lenore A. Boling ◽  
Barbara J. Beake
Keyword(s):  
Stimulant Drugs ◽  
Medical Needs

Genetic factors influence ethanol-induced uroporphyria inHfe(?/?) mice

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 942-950 ◽  
Author(s):  
Nadia Gorman ◽  
Heidi W. Trask ◽  
William J. Bement ◽  
Juliana G. Szakacs ◽  
George H. Elder ◽  
...  
Keyword(s):  
Genetic Factors

Bestimmung der DNA-Schädigung in vitro

2010 ◽  
Vol 49 (S 01) ◽  
pp. S64-S68
Author(s):  
E. Dikomey
Keyword(s):  
Dna Damage ◽  
Cell Lines ◽  
Chromosome Aberrations ◽  
Genetic Factors ◽  
Double Strand Breaks ◽  
Strand Breaks ◽  
Cell Inactivation ◽  
Repair Mechanisms ◽  
Break Repair

SummaryIonising irradiation acts primarily via induction of DNA damage, among which doublestrand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of doublestrand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about doublestrand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.

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